intrinsic factor
ANTIBODY TO INTRINSIC FACTOR IN SERUM FROM PATIENTS WITH PERNICIOUS ANEMIA
... The interaction of sera from pernicious anemia patients and purified human intrinsic factor IF-Co60B,2 complex has been studied by in vivo absorption tests and by in vitro electrophoreti[r] ...
11
Malabsorption of hemoglobin iron in pernicious anemia: correction with intrinsic factor—containing substances
... hog intrinsic factor (IF) concentrates doubled the absorption of hemoglobin iron in these patients as did normal (neutralized depepsinized) human gastric ...
8
MECHANISM OF INTRINSIC FACTOR ACTION IN EVERTED SACS OF RAT SMALL INTESTINE
... In a calcium-free medium, no enhancement of vitamin B12 uptake attributable to intrinsic factor occurs on liver slices, but a definite enhancement is still observable with everted sacs o[r] ...
9
Radioiodination of human intrinsic factor
... Human intrinsic factor (IF) saturated with 60 Co-labeled cyanocobalamin ( 60 CoB 12 ) was purified and then iodinated with 125 I to yield 125 I-labeled IF- 60 CoB 12 preparations of high specific ...
10
Studies on Antibody to Intrinsic Factor
... Sera from a group of 79 patients with pernicious anemia were studied for the presence of antibody to intrinsic factor. Two general types of antibody activity were found, and it was possible to distinguish ...
7
Kinetics of the Attachment of Intrinsic Factor Bound Cobamides to Ileal Receptors
... the intrinsic factor-cyanocobalamin complex was ...to intrinsic factor was determined by competition experiments, the analogs could be separated into two categories: those with affinities ...
12
Infection Susceptibility in Gastric Intrinsic Factor (Vitamin B12) Defective Mice Is Subject to Maternal Influences
... gastric intrinsic factor (Gif) being responsible for trans- porting Cbl through the small intestine and facilitating endocyto- sis in the distal ileum ...
10
IN VITRO ASSAY FOR HUMAN INTRINSIC FACTOR
... Supporting the validity of the methodology here described as an assay for human intrinsic factor activity are the following observations: a the material in human gastric juice which enha[r] ...
17
Intrinsic Factor mediated Absorption of Cobalamin by Guinea Pig Ileal Cells
... of intrinsic factor and cobalamin during cobalamin absorption, we incubated enterocytes isolated from guinea pig ileum for periods of up to 30 min with 57 Co- labeled cyano-cobalamin bound either to human ...
10
THE IMMUNOLOGIC IDENTIFICATION AND QUANTITATION OF HUMAN INTRINSIC FACTOR IN GASTRIC SECRETIONS
... Similarly, although the electrophoretic mobility of bound Co60B12 in saliva and in gastric juice from patients with pernicious anemia exceeded that of bound Co60B1, in normal, neutralize[r] ...
9
STUDIES ON THE ABSORPTION BY GUINEA PIG INTESTINE OF CYANOCOBALAMIN INCUBATED WITH INTRINSIC FACTOR
... testinal absorption of a number of substances 11, the observation that a portion of the cyanocobalamin taken up in the presence of normal human gastric juice NHGJ by the perfused isolate[r] ...
9
Promyelocytic Leukemia Protein Is a Cell-Intrinsic Factor Inhibiting Parvovirus DNA Replication
... replication factor C, proliferating cell nuclear antigen, and replication protein A (RPA) (36, 37), al- though second-strand synthesis has not been examined ...
12
Evidence for involvement of cyclic nucleotides in intrinsic factor secretion by isolated rabbit gastric mucosa
... Moreover, if the stimulation of IF secretion by IBMX implies the presence of endogenous histamine in the tissue, as we have reasoned in the preceding paragraph, and if histamine stimulat[r] ...
7
SEQUENTIAL MECHANISMS IN THE ENHANCED ABSORPTION OF VITAMIN B12 BY INTRINSIC FACTOR IN THE RAT
... Because it was shown in dialysis experiments that EDTA neither bound Co60-B12 TABLE V nor affected its dialyzability when bound to rat Effects of metabolic inhibitors on the activity of [r] ...
17
EFFECT OF TRANSPLACENTAL TRANSFER OF ANTIBODY TO INTRINSIC FACTOR
... diagnosis and throughout her pregnancy. She subsequently delivered a full-term, male infant who was hematologically nor- mal. At the time of birth, antibody to I.F. was detected in tile [r] ...
7
Glycolysis Is an Intrinsic Factor for Optimal Replication of a Norovirus
... important factor for optimal MNV infection, while inhibiting the PPP and OXPHOS showed a relatively minor impact of these pathways on MNV ...an intrinsic host factor that determines the extent of ...
18
IMMUNOLOGIC STUDIES WITH INTRINSIC FACTOR IN MAN
... Postimmunization sera from both patients closely resembled rabbit anti-HIFC serum in their ability to 1 precipitate P-HIFC in agar diffusion systems, 2 prevent the electrophoretic migrat[r] ...
16
Identification of a macromolecular factor in the ileum which binds intrinsic factor and immunologic identification of intrinsic factor in ileal extracts
... reaction in sodium EDTA but not calcium EDTA, (f) incubating gastric juice- 57 CoB 12 with an extract of jejunal mucosa. Sephadex gel filtration was used to demonstrate that the factor in the ileal extract which ...
12
Isolation and Characterization of an Abnormal Human Intrinsic Factor
... Patient IF-B11 and normal IF-B12 were precipitated in an equivalent manner data not presented when quantitative immunoprecipitation studies were performed with varying amounts of serum, [r] ...
11
CONGENITAL PERNICIOUS ANEMIA: EFFECTS ON GROWTH, BRAIN, AND ABSORPTION OF B12
... : Notes on vitamin B,, absorption; autoirnmunity and childhood pernicious anemia; relation of intrinsic factor to blood group substance. : Pernicious anemia in childhood[r] ...
10