intrinsic resistance
Intrinsic resistance to EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer with activating EGFR mutations
... with intrinsic resistance to EGFR ...with intrinsic resistance due to the presence of de novo T790M mutations as an initial treatment ...
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Multidrug Intrinsic Resistance Factors in Staphylococcus aureus Identified by Profiling Fitness within High Diversity Transposon Libraries
... impacting resistance to multiple antibiotics could inform the design of new compounds and lead to more-effective antimicrobial ...in resistance to individual antibiotics, including graRS and vraFG ...
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Inhibition of the ATP Synthase Eliminates the Intrinsic Resistance of Staphylococcus aureus towards Polymyxins
... IMPORTANCE Bacterial pathogens that cause disease in humans remain a serious threat to public health, and antibiotics are still our primary weapon in treating bac- terial diseases. The ability to eradicate bacterial ...
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Intrinsic Resistance of Burkholderia cepacia Complex to Benzalkonium Chloride
... The resistance of ...otic resistance of efflux pumps of the RND and MFS families and the DsbA-DsbB disulfide bond formation system has been pro- vided from the corresponding mutants generated by reverse ge- ...
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Intrinsic resistance of feline peritoneal macrophages to coronavirus infection correlates with in vivo virulence.
... The avirulent coronaviruses infected fewer macrophages, produced lower virus titers, were less able to sustain viral replication, and spread less efficiently to other susceptible macroph[r] ...
5
Differential Sensitivity of Murine Leukemia Virus to APOBEC3-Mediated Inhibition Is Governed by Virion Exclusion
... human intrinsic resistance factors are able to restrict the replication of Vif-deficient forms of human immunodeficiency virus type 1 (HIV-1), they are unable to block replication of wild-type HIV-1 due to ...
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Original Article Connexin 43 affects intrinsic gefitinib resistance of NSCLC cells by GJIC
... the intrinsic resistance to TKIs in cancer therapy remains a critical limitation to the effi- cacy of these agents, therefore, it is crucial that we find out the thorough understanding of the underlying ...
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General Mechanisms of Resistance to Pharmacological Therapy Applied to Tumor Cells
... drug resistance is one of problems during the treatment of local and/or disseminated disease, also is one of the biggest problems in relapses of ...inhibitors. Resistance constitutes a lack of response to ...
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An Evolutionarily Conserved Mechanism for Intrinsic and Transferable Polymyxin Resistance
... colistin resistance protein EptA, two plasmid-borne PEA transferases (MCR-1 [46] and MCR-2 [16, 17], with 81% amino acid identity) that can confer colistin resistance to recipient bacterial strains have ...
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Indole Reverses Intrinsic Antibiotic Resistance by Activating a Novel Dual Function Importer
... their intrinsic resistance to multiple antibiotics ...this intrinsic antibiotic resistance is not well understood, possibly because Lysobacter ...the intrinsic antibiotic ...
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Preservation of Dendritic Cell Function during Vesicular Stomatitis Virus Infection Reflects both Intrinsic and Acquired Mechanisms of Resistance to Suppression of Host Gene Expression by Viral M Protein
... both intrinsic and acquired mechanisms of resistance to the inhibitory effects of VSV M pro- ...DC resistance in vivo, the current study does not address which splenocyte subtypes are directly ...
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SAMHD1 restricts HIV 1 reverse transcription in quiescent CD4+T cells
... the intrinsic resistance of unstimulated PBMCs to HIV-CMV-EGFP infection, homozygous dele- tion increased the susceptibility of both quiescent CD4+ T-cells and monocytes (Figure 3a, b, c), indicating that ...
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Enhanced electrical properties of vertically aligned carbon nanotube epoxy nanocomposites with high packing density
... the intrinsic resistance of the tube and (2) the tunneling resistance due to nanoscale gaps occurring between the epoxy-coated tubes along ...
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Intrinsic Antimicrobial Resistance Determinants in the Superbug Pseudomonas aeruginosa
... antiseptic/disinfectant resistance or lacks intrinsic resistance to these antimicrobials ...into resistance mechanisms that occur in individuals receiving multi- ple ...
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A best practice fall prevention exercise program to improve balance, strength / power, and psychosocial health in older adults: study protocol for a randomized controlled trial
... A non-invasive bioelectrical impedance analysis (BIA) will be conducted before balance and strength / power assessments to minimize the effect of hydration status on measurements. Participants will be instructed to ...
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Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma
... BIM is a pro-apoptotic BH3-only domain protein that is regulated both transcriptionally and post- transcriptionally by many signaling pathways including BRAF/MEK/ERK, PI3K/AKT, p38 MAPK and JNK/ SAPK [43]. It exerts its ...
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CMOS low noise amplifiers for 1.575 GHz GPS applications
... The main noise sources of a LNA with such inductive de- generation topology are the intrinsic thermal noise of input transistor M1, the gate resistance associated with it ( R g ) and the[r] ...
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Compensatory Evolution in Rifampin-Resistant Escherichia coli
... Evolution for higher levels of rif-resistance: While we did not see evolution of increased rif resistance in rifampin-free cultures, the MICs of all mutants evolved in the presence of rifampin did increase. ...
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Human primary myoblast cell cultures from non diabetic insulin resistant subjects retain defects in insulin action
... insulin resistance is intrinsic in skeletal muscle cells and would be maintained in cell culture, primary myoblast cell cultures were established from non-dia- betic Pima Indians with varying degrees of ...
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BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity
... Several studies have brought evidence for pathways and mechanisms to explain the acquired sensitivity of can- cer cells to I-BET proteins [41, 60, 62]. Yet, no unifying hypothesis which would enable mechanistic ...
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