Invasion and Metastasis
The impact of hypoxia in pancreatic cancer invasion and metastasis
... impacts invasion and metastasis in pancreatic cancer are being elucidated, hypoxia is emerging as a key determinant of pancreatic cancer malignancy as well as an important target for ...cancer ...
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The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma
... distant metastasis of a sin- gle cell, which has a negative influence on the extent of ...vanced metastasis detection at the cellular ...and invasion of HCC cells from the signalling pathway, which ...
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Podoplanin: An Insight into its Role in Tumor Invasion and Metastasis
... node metastasis, whereas in potentially malignant disorders it indicates a higher risk of malignant ...podoplanininduced metastasis have been ...control invasion and ...
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Metalloproteinases: role in breast carcinogenesis, invasion and metastasis
... The matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases. Their primary function is degradation of proteins in the extracellular matrix. Currently, at least 19 members of this family are known ...
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Ecosystems of invasion and metastasis in mammary morphogenesis and cancer
... Growth factors and their receptors, many of which belong to the tyrosine kinase family, not only modulate cell proliferation but also signal to migration, cell-cell adhesion and survival, as is suggested by double names ...
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Ezrin promotes invasion and metastasis of pancreatic cancer cells
... motility, invasion and the abil- ity of anchorage-independent growth, which are all tumor cells ...promote invasion and metastasis in ...gression, invasion and ...
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Receptor-bound urokinase-type plasminogen activator in human colon cancer invasion and metastasis
... Statement Acknowledgements Abstract Abbreviations List of Figures CHAPTER 1 INTRODUCTION 1.1 Mechanisms of Tumour Invasion and Metastasis 1.1.1 Major steps in the process of metastasis 1[r] ...
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miR-10b suppresses cell invasion and metastasis through targeting HOXA3 regulated by FAK/YAP signaling pathway in clear-cell renal cell carcinoma
... and invasion capabilities in ccRCC cells To further explore the mechanisms underlying the inhibitory effects of miR-10b on tumor invasion and metastasis, we performed bioinformatics analysis to ...
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Cervical invasion, lymphovascular space invasion, and ovarian metastasis as predictors of lymph node metastasis and poor outcome on stages I to III endometrial cancers: a single center retrospective study
... cervical invasion in 292 ...nodal metastasis in univariate ...cervical invasion could be almost excluded in patients diagnosed by CE-MRI as not having cervical invasion ...
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The roles of microRNAs in the regulation of tumor metastasis
... EMT, invasion and metastasis [52, ...cell invasion in vitro and metastatic colonization of the lung in vivo via the targeting of ...pulmonary metastasis in vivo, most likely by targeting ROCK2 ...
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The role of mTOR and phospho-p70S6K in pathogenesis and progression of gastric carcinomas: an immunohistochemical study on tissue microarray
... of invasion, lymph node metastasis and UICC ...growth, invasion and metastasis of gastric carcinoma and might be employed to indicate the biological behaviors of gastric carcinoma in ...
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CCR7 enhances TGF-β1-induced epithelial-mesenchymal transition and is associated with lymph node metastasis and poor overall survival in gastric cancer
... With nearly one million new cases annually worldwide, gastric cancer (GC) is the fifth most common malignant disease and the second leading cause of cancer mortality. Despite improvements in diagnostic and treatment ...
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Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma
... both p53-dependent and independent pathways [23]. Mesenchyme Forkhead 1 (FOXC2) which induced by Twist, Snail, Goosecoid and TGF-β1 plays a central role in promoting invasion and metastasis in human ...
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SIGNIFICANCE OF MMPS EXPRESSION ON OSCC CLINICAL OUTCOME: A REVIEW
... the invasion and metastasis of ...prognosis, metastasis, invasion, stage and other related ones During 1999 to ...with invasion, metastasis recurrence, prognosis and patient ...
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Original Article Expression of ORAOV1, CD133 and WWOX correlate with metastasis and prognosis in gastric adenocarcinoma
... peculiarity, self-renewal and aptitude for multi- ple differentiation promote GAC cells rapid growth. Meanwhile, Overexpression of ORAOV1 also contributes to tumorigenesis by the pro- motion of cancer cells proliferation ...
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Forecast of actin-binding proteins as the oncotarget in osteosarcoma – a review of mechanism, diagnosis and therapy
... steps can induce the invasion and metastasis of cancer cells. This also suggests that tumorigenesis may not occur by means of mutative expression of single proteins but may be affected by multiple abnormal ...
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Original Article Expression of vimentin and Oct-4 in gallbladder adenocarcinoma and their relationship with vasculogenic mimicry and their clinical significance
... GBAC has a very poor prognosis and a low 5-year survival rate, which is why finding new biological therapy is very important. Vimentin is a mesenchymal marker that is up-regulated in migratory cells and expressed at ...
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Nutrient Deprivation Modulates the Metastatic Potential of Breast Cancer Cells
... the metastasis of spontaneous breast cancer in mice ...acquire metastasis-associated phenotypes following activation of Wnt-beta-catenin pathway ...in invasion and metastasis (21, ...
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The influence of vascular endothelial growth factor-A and matrix metalloproteinase-2 and -9 in angiogenesis, metastasis, and prognosis of endometrial cancer
... myometrial invasion and ...with metastasis than in the group without metas- tasis (median [range]: 743 pg/mL [546–1,183 pg/mL] vs 383 pg/mL [31–1,524 pg/mL]) and hence VEGF was related to poor prognosis and ...
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Oridonin inhibits pancreatic cancer cell migration and epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling pathway
... [32]. Metastasis may be largely dependent on the ability of cancer cells to acquire EMT characteristics [33, ...and invasion of breast cancer cells by repress- ing EMT under hypoxic conditions ...and ...
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