Invasive Candidiasis
Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy
... There are three main groups of antifungals: the azoles, the polyenes, and the echinocandins. The selection of an antifungal regimen is based on multiple factors, includ- ing epidemiological data, patient characteristics, ...
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Micafungin versus anidulafungin in critically ill patients with invasive candidiasis: a retrospective study
... treatment of invasive candidiasis [10–15]. The antifungal activity, pharmacokinetics and toxicity profile of each echinocandin is slightly different, but the relevance of this finding remains unclear [16]. ...
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Breakthrough Invasive Candidiasis in Patients on Micafungin
... with invasive candidiasis (IC) breaking through >3 doses of micafungin therapy during the first 28 months of its use at our center: MICs were determined and hot-spot regions within FKS genes were ...
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Treatment of candidemia and invasive candidiasis in the intensive care unit: post hoc analysis of a randomized, controlled trial comparing micafungin and liposomal amphotericin B
... of invasive Candida infections in ICU patients is important because logistic regression analyses of data from observational studies suggest that Candida infection is an independent predictor of mortality among ICU ...
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Diagnosis of invasive candidiasis by detection of mannan antigen by using the avidin biotin enzyme immunoassay
... The diagnosis of invasive candidiasis was attempted by detection of circulating mannan antigen by using an avidin-biotin-amplified enzyme-linked immunosorbent assay AB-ELISA, and this me[r] ...
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Mannose in body fluids as an indicator of invasive candidiasis
... Studies utilizing gas-liquid chromatography have suggested that patients with invasive candidiasis may be distinguished by having elevated serum concentrations of D-arabinitol 10, 18 and[r] ...
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Pharmacokinetics of Micafungin in Adult Patients with Invasive Candidiasis and Candidemia
... Micafungin is an efficacious and well-tolerated echinocandin with in vitro and in vivo activity against a broad range of Candida species. The objective of this randomized, double-blind study was to examine the ...
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Epidemiology and risk factors for invasive candidiasis
... The present article reviews the incidence of IC, the most common infectious pathogens and the risk factors for candidiasis. For this purpose, a literature search was performed in last 15 years via PubMed using ...
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PCR Diagnosis of Invasive Candidiasis: Systematic Review and Meta Analysis
... Invasive candidiasis (IC) is a significant cause of morbidity and ...suspected invasive candidiasis, the pooled sensitivity for the diagnosis of candidemia was ...
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Consensus statement on the management of invasive candidiasis in Indian scenario
... of invasive infections in intensive care units ...of invasive candidiasis which is vital to initiate appropriate and timely treatment and improve ...deep-seated candidiasis and rise of drug- ...
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Systemic antifungal therapy for proven or suspected invasive candidiasis: the AmarCAND 2 study
... This study on SAT in French ICUs enrolled 291 patients with PIC and 544 with SIC. Patients receiving SAT for SIC were more severely ill than those having SAT for PIC: they had higher severity scores and more often septic ...
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Echinocandins for management of invasive candidiasis in patients with liver disease and liver transplantation
... Abstract: Candida species remains one of the most important causes of opportunistic infections worldwide. Invasive candidiasis (IC) is associated with considerable morbidity and mortality in liver disease ...
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Weekly use of fluconazole as prophylaxis in haematological patients at risk for invasive candidiasis
... There are, however, unanswered questions with respect to the possible emergence of resistance to fluconazole over time and the persistent lack of evidence of effectiveness for this exceptional prophylactic regimen. In ...
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Comparison of the incidence, clinical features and outcomes of invasive candidiasis in children and neonates
... of invasive Candida infections vary widely among different geographic areas, patient characteristics and ages, and institutions [13, ...of invasive candidiasis in neonates and children, we compared ...
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Invasive candidiasis in low birth weight preterm infants: risk factors, clinical course and outcome in a prospective multicenter study of cases and their matched controls
... Variables related to the drug, dose, timing and duration of treatment did not affect the mortality rate in IC cases. Prompt treatment and appropriate dosing for neonatal IC are felt to be important management strategies ...
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Diagnosing Invasive Candidiasis
... for invasive candidiasis were ⬃ 75% to 80% and ⬃ 80%, respectively (95% confidence intervals [CI], ⬃ 65% to 85% and ⬃ 75% to 85%, respectively) (12, ...without invasive fungal ...of invasive ...
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Fluconazole Prophylaxis in Extremely Low Birth Weight Neonates Reduces Invasive Candidiasis Mortality Rates Without Emergence of Fluconazole-Resistant Candida Species
... had invasive candidiasis (all candidemia) during flucon- azole prophylaxis; before fluconazole prophylaxis, there were 19 cases (candidemia: 17 cases; meningitis: 2 ...cases). Invasive ...
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Treatment and prophylaxis of invasive candidiasis with anidulafungin, caspofungin and micafungin - review of the literature
... with invasive Candida infection has not been studied in dedicated prospective ...pivotal invasive candidiasis trials in- cluded comparatively small numbers of patients with neutropenia at baseline ...
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Micafungin in the treatment of invasive candidiasis and invasive aspergillosis
... of invasive fungal infections, including candidiasis and aspergillosis, despite the greater in vitro potency of anidulafungin and micafungin (Paderu et al 2007; Wiederhold et al ...and invasive ...
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Invasive candidiasis and candidemia in pediatric and neonatal patients: A review of current guidelines
... Several international and national guidelines have been proposed for the treatment and prevention of invasive candidiasis/candidemia (IC/C) in both neonatal and pediatric patients. This article is a review ...
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