Iodothyronine Deiodinase
Type 2 iodothyronine deiodinase is highly expressed in human thyroid
... 2 iodothyronine deiodinase (D2) is a recently cloned selenodeiodinase thought to provide intracellular 3,5,3' triiodothyronine (T3) to a restricted group of ...1 deiodinase (D1) is known to be ...
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Deubiquitination of type 2 iodothyronine deiodinase by von Hippel–Lindau protein–interacting deubiquitinating enzymes regulates thyroid hormone activation
... 2 iodothyronine deiodinase (D2) is an integral membrane ER-resident selenoenzyme that acti- vates the pro-hormone thyroxine (T4) and supplies most of the 3,5,3′-triiodothyronine (T3) that is essential for ...
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Pregnant rat uterus expresses high levels of the type 3 iodothyronine deiodinase
... Although thyroid hormones are critically important for the coordination of morphogenic processes in the fetus and neonate, premature exposure of the embryo to levels of the hormones present in the adult is detrimental ...
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Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes
... The goal of these studies was to define the rate-limiting steps in the inactivation of type 2 iodothyronine deiodinase (D2). We examined the effects of ATP depletion, a lysosomal protease inhibitor, and an ...
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Cloning of the mammalian type II iodothyronine deiodinase A selenoprotein differentially expressed and regulated in human and rat brain and other tissues
... II deiodinase (DII) converts thyrox- ine to the active hormone 3,5,3 9 -triiodothyronine, and in the rat is expressed in the brain, pituitary gland, and brown ad- ipose tissue ...
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Interrelationships among thyroxine, growth hormone, and the sympathetic nervous system in the regulation of 5' iodothyronine deiodinase in rat brown adipose tissue
... acceleration of the rate of disappearance of the enzyme. Growth hormone (GH) also inhibits BAT 5'D but by a mechanism mediated through a long-lived messenger that correlates with growth rate. This explains the failure of ...
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Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans
... 16. Sharifi, J., and St. Germain, D.L. 1992. The cDNA for the type I iodothyronine 5′-deiodinase encodes an enzyme manifesting both high Km and low Km activity. Evidence that rat liver and kidney contain a ...
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The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue
... Most homeotherms maintain body temperature by increasing heat production in response to cold. This process, adaptive thermogenesis, is achieved by shivering or by uncoupling oxidative phosphorylation in brown adipose ...
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Two patients with atypical low triiodothyronine syndrome: primary deiodinase abnormalities?
... 12 Rosene ML, Wittmann G, Arrojo e Drigo R, Singru PS, Lechan RM & Bianco A 2010 Inhibitors of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment. ...
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Clinical and Biochemical Profile of Deiodinase Enzymes and Thyroid Function Hormones in Patients of Fluorosis
... The follicular cells of the thyroid gland produce thyroid hormones thyroxine (T4) and triiodpthyronin (T3) which modulate a variety of physiological processes (Larsen et al.2002). The main secretion product of the ...
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Functional identification of an osmotic response element (ORE) in the promoter region of the killifish deiodinase 2 gene (FhDio2)
... in hydro-osmotic homeostasis in fish remains a controversial issue. Previous studies have shown that in Fundulus heteroclitus (killifish) hypo-osmotic stress increases liver iodothyronine deiodinase type 2 ...
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Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme
... Type 3 iodothyronine deiodinase (D3) catalyzes the conversion of T4 and T3 to inactive metabolites. It is highly expressed in placenta and thus can regulate circulating fetal thyroid hormone concentrations ...
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Somatostatin inhibits rat hepatic T4 5' deiodinase The effect is independent of the associated hypoinsulinemia
... Somatostatin decreases the serum 3,5,3'-triiodothyronine (T3) concentration in athyreotic subjects treated with L-thyroxine (T4). The present study was performed to determine the effect of somatostatin on ...
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Vitamin E administration attenuates the tri iodothyronine induced modification of heart electrical activity in the rat
... tri- iodothyronine-induced acceleration of lipid peroxidation is consistent with several reports showing a therapeutic function for vitamin E in experimental ...
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The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration
... The deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohormone thyroxine ...2 deiodinase (D2) is essential for normal mouse myogenesis and muscle ...
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Effects of previous experience on total blood and free iodothyronine responses to isolation, restraint and shearing in sheep (Ovis aries)
... Finally, the increases in T 3 , T 4 , fT 3 and fT 4 fol- lowing restraint and shearing could indicate a re- sponse to handling stress and suggest that sheep, independent of sex and previous experience, may successively ...
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MECHANISTIC ROLE OF VARUNA (CRATAEVA NURVALA) EXTRACT ON THYROID GLAND AND ITS HISTOLOGY THROUGH IODOTHYRONINE DEIODINASES
... Vol 11, Issue 10, 2018 Online 2455 3891 Print 0974 2441 MECHANISTIC ROLE OF VARUNA (CRATAEVA NURVALA) EXTRACT ON THYROID GLAND AND ITS HISTOLOGY THROUGH IODOTHYRONINE DEIODINASES ARSHVIR KAUR1, SANTOS[.] ...
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Ether Link Cleavage Is the Major Pathway of Iodothyronine Metabolism in the Phagocytosing Human Leukocyte and also Occurs In Vivo in the Rat
... From these findings we conclude the following: a ELC is the major pathway for the degradation of T4 during leukocyte phagocytosis, and accounts for 50% of the disposal of this iodothyron[r] ...
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Evidence for Two Pathways of Iodothyronine 5′ Deiodination in Rat Pituitary That Differ in Kinetics, Propylthiouracil Sensitivity, and Response to Hypothyroidism
... Thyroid Diagnostic Center, Department of Medicine, Brigham and Women's Hospital, Howard Hughes Medical Institute Laboratory, Harvard Medical School, Boston, Massachusetts 02115 A B S T R[r] ...
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Iodothyronine Release from the Perfused Canine Thyroid following Cessation of Stimulation: RAPID DECLINE OF TRIIODOTHYRONINES IN COMPARISON WITH THYROXINE
... To see whether such a mechanism may fit the experimental data obtained using the perfused canine thyroid, and to get an idea of the delay in T4 release necessary for inducing the observe[r] ...
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