IR, insulin receptor
Recruitment of insulin receptor substrate 1 by erbB3 impacts on IGF IR signalling in oestrogen receptor positive breast cancer cells
... factor receptor (IGF-IR) signalling classically involves phos phory lation of insulin receptor substrate-1 (IRS-1) to recruit key down- stream signalling pathways eff ecting breast cancer cell ...
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Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy
... test; IR: insulin receptor; IRS-1: IR scaffold-1; IR β : IR β subunit; ITT: insulin tolerance test; Met: metformin; mTOR: mammalian target of rapamycyn; OA: okadaic acid; ...
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Hypoglycemic effects of Trichosanthes kirilowii and its protein constituent in diabetic mice: the involvement of insulin receptor pathway
... TK. Insulin receptor (IR) kinase activity assay and glucose tolerance tests in diabetic mice were further used to elucidate the hypoglycemic mechanisms and efficacies of ...
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In vivo stimulation of the insulin receptor kinase in human skeletal muscle Correlation with insulin stimulated glucose disposal during euglycemic clamp studies
... between insulin receptor (IR) kinase activity and insulin action in vivo in humans, we measured glucose disposal rates (GDR) during a series of euglycemic clamp ...measured IR kinase ...
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DEVELOPING SELECTIVE INHIBITORS OF PTP1B OVER TCPTP
... Insulin resistance is the primary cause for the type-2 diabetes, affected by more than 50million people in ...of insulin receptor which suppress the insulin action by dephosphorylating ...
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Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21.
... and insulin resistance in adult ...increased insulin-induced phos- phorylation of the insulin receptor (IR) and Akt in peripheral ...and insulin signaling and improved whole-body ...
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Insulin like growth factors and insulin like growth factor binding proteins in mammary gland function
... the insulin- receptor substrate/phosphatidylinositol 3-kinase (PI3K)/ protein kinase B pathway and the Ras/Raf/mitogen- activated protein kinase (MAPK) pathway (for a review on mechanisms of IGF signalling, ...
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Tissue specific insulin resistance in mice with mutations in the insulin receptor, IRS 1, and IRS 2
... of insulin that may potentially activate IGF-1 ...of insulin and IGF-1 receptors, it will be necessary to perform glu- cose clamps at submaximal insulin ...the ir/irs-1 mouse have provided a ...
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Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
... ranges; IR: insulin resistance; IRS: insulin receptor substrate; JAK‑STAT : Janus kinase‑Signal Transducer and Activator of Transcription; JNK: c‑Jun N‑terminal kinase; K: clot kinetics; LDL: ...
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Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions.
... 6835 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest We have shown previously that the extracellular sequences of the human insulin receptor IR and the insulin-like grow[r] ...
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Cellular distribution of insulin degrading enzyme gene expression Comparison with insulin and insulin like growth factor receptors
... both insulin and IGFs and has been proposed to play a role in signal termination after binding of these peptides to their ...with insulin receptor (IR) and IGF-I receptor (IGFR) gene ...
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<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... rs3820926 are located in the 272kb and 263kb upstreams from the transcription start site of IRS-1, respectively. This haplotype could increase the risk of MDD. Genetic mechanisms suggest that the promoter region of SNPs ...
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Daily physical activity predicts degree of insulin resistance: a cross-sectional observational study using the 2003–2004 National Health and Nutrition Examination Survey
... Obesity is associated with increased risk of IR and type 2 diabetes [26,27]. In our complete model, we show that body fat percentage was most strongly associated with IR. With two-thirds of the U.S. ...
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Muscle growth and flesh quality of farmed Atlantic halibut (Hippoglossus hippoglossus) in relation to season of harvest
... Hydroxyproline Insulin-like Growth Factor-I Insulin-like Growth Factor-I receptor a Insulin-like Growth Factor-I receptor b Insulin-like Growth Factor-II Internal standard kilogram litre[r] ...
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Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism
... of insulin to stimulate activity is virtually abolished ...and insulin/se- rum-stimulated p70 kinase activity within 30 min ...of insulin/serum stimulation, because the p70 activ- F IG ...mixture. ...
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Abnormal regulation of ribosomal protein S6 kinase by insulin in skeletal muscle of insulin resistant humans
... major insulin-stimulated S6 kinase eluted as peak 2 and is antigenically related to a 70- kD S6 ...that insulin resistance impairs signaling to the 70-kD S6 ...
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Androgen receptor CAG repeat polymorphism is not associated with insulin resistance and diabetes among South Asian males
... Sample size was 100 (response rate—90.9%). There were 53 patients with diabetes (cases, response rate—96.4%) and 47 patients without diabetes (con- trols, response rate—85.4%). Mean age (± SD) was 49.6 ± 10.7 years ...
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Early-age feed restriction affects viability and gene expression of satellite cells isolated from the gastrocnemius muscle of broiler chicks
... Total RNA of satellite cells was extracted, quality verified and 2 μg of total RNA was reverse tran- scribed as described previously [5]. Real-time PCR was performed to quantify the mRNA expression of GHR, IGF-I, ...
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Peripheral neuropathy is associated with insulin resistance independent of metabolic syndrome
... Results: (1) The percentage of PN was 4.0% in our study. Patients with MetS (47.7%) had a higher percentage of PN (5.5% vs. 2.6%, respectively, P = 0.001). With the components of MetS increased (non-MetS, three, four, ...
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Association between triglyceride glucose index and arterial stiffness in Korean adults
... Table 1 shows the clinical and laboratory characteristics of the study population. Subjects were stratified into four groups based on their TyG index levels. Significant dif- ferences in metabolic parameters were ...
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