IRF-1, interferon regulatory factor-1
Functional Analysis of Human Herpesvirus 8-Encoded Viral Interferon Regulatory Factor 1 and Its Association with Cellular Interferon Regulatory Factors and p300
... the interferon regulatory factor (IRF) ...viral IRF 1 (vIRF-1), has been cloned, and it was shown that, when overexpressed, it down modulates the ...
9
Interferon Regulatory Factor 1 Restricts Gammaherpesvirus Replication in Primary Immune Cells
... Measurement of 25-hydroxycholesterol. Bone marrow macrophages derived from BL6, IRF-1 ⫺/⫺ , and CH25H ⫺/⫺ mice were mock infected or infected with wt MV68 at an MOI of 10 PFU/cell for 24 h. Conditioned ...
12
Original Article Regulatory effect of interferon regulatory factor-1 on lymphatic enhancing factor 1
... Abstract: Interferon regulatory factor (IRF)-1 is one important transcriptional factor and exerts critical roles in anti-vi- rus and ...enhancing factor (LEF)-1 is ...
8
Interferon Regulatory Factor 1 and Type I Interferon Cooperate To Control Acute Gammaherpesvirus Infection
... pathology. Interferon regulatory factor 1 (IRF-1) is a tumor suppressor that is also involved in the regulation of innate and adaptive im- mune ...I interferon (IFN) and ...
12
Suppression of Growth by All-trans Retinoic Acid Requires Prolonged Induction of Interferon Regulatory Factor 1 in Cervical Squamous Carcinoma (SiHa) Cells
... for IRF-1 were custom designed and synthesized (Genosys, The Woodlands, ...KCl, 1 mM dithiothreitol, 1 mM EDTA, 0.5% NP-40, and 1 mM phenylmethylsulfonyl di- ...glycerol, 1 mM ...
5
Regulation of DNA-Raised Immune Responses by Cotransfected Interferon Regulatory Factors
... Interferon regulatory factor 1 (IRF-1), IRF-3, and IRF-7 have been tested as genetic adjuvants for influenza virus hemagglutinin (HA) and nucleoprotein vaccine ...
8
Type I interferonopathies in pediatric rheumatology
... IRF: interferon regulatory factors; ISG15: interferon-stimulated gene 15; JAK: Janus kinase; JASL: Japanese autoinflammatory syndrome with lipodystrophy; JMP: joint contractures, muscle ...
12
HIV-1 Vpu Does Not Degrade Interferon Regulatory Factor 3
... on IRF-3 expression levels strongly argues against Vpu-mediated degradation of ...than IRF-3-dependent ...on IRF-3 expression were sparse in the studies of Doehle and cowork- ers, and the effects of ...
6
Chimeric oncogenic interferon regulatory factor 2 (IRF 2): Degradation products are biologically active
... that IRF-2 is involved in immu- nomodulation, hematopoietic differentiation, cell cy- cle regulation and ...murine IRF-2 as GST (Glutathione-S-Transferase)- IRF-2 fusion protein in ...combinant ...
9
Differential Regulation of Interferon Regulatory Factor (IRF)-7 and IRF-9 Gene Expression in the Central Nervous System during Viral Infection
... The IRF-7 and IRF-9 genes have a differential requirement for STAT1 following LCMV ...the IRF-7 and IRF-9 genes were regulated through the classi- cal interferon stimulated gene ...
14
Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy
... the IRF family [23, ...and interferon, IRF1 acts as a transcriptional activator of specific IFN- stimulated genes that mediate diverse functions including cellular responses to inflammation, programmed cell ...
14
Interferon regulatory factor (IRF) 3 is critical for the development of experimental autoimmune encephalomyelitis
... the back. Mice were sacrificed after 9 to 12 days, and their lymph nodes and spleens were retrieved. Cells were cul- tured (spleens and lymph nodes combined) at a density of 8 × 10 6 cells/ml in RPMI 1640 medium with 10% ...
7
Interferon Regulatory Factor IRF-7 Induces the Antiviral Alpha Interferon Response and Protects against Lethal West Nile Virus Infection
... of IRF-7 in regulating host defense responses, we infected wild- type and IRF-7 ⫺/⫺ bone marrow-derived CD11c ⫹ mDC with WNV and assayed viral replication and IFN production ...in IRF-7 ⫺/⫺ mDC than ...
11
Critical Role for Interferon Regulatory Factor 3 (IRF-3) and IRF-7 in Type I Interferon-Mediated Control of Murine Norovirus Replication
... in IRF-3 ⫺/⫺ ⫻ IRF-7 ⫺/⫺ macrophages, we observed IFN-␣4 and IFN-  mRNA induction in IRF-3 ⫺/⫺ ⫻ IRF-7 ⫺/⫺ dendritic cells, especially at later time ...examined, IRF-3 ⫺/⫺ ⫻ ...
9
Interferon Regulatory Factor 7 Is Associated with Epstein-Barr Virus-Transformed Central Nervous System Lymphoma and Has Oncogenic Properties
... functions. IRF-7 may be involved in switching EBV latency types and in the maintenance of latency through its regulation of the viral BamHI Q promoter (Qp) for Epstein-Barr nuclear antigen 1 ...
9
Interferon-Regulated Pathways That Control Hepatitis B Virus Replication in Transgenic Mice
... the interferon (IFN)-inducible genes, those for the IFN regulatory factor 1 (IRF-1), RNase L, and double- stranded RNA-activated protein kinase (PKR) systems are some of the best ...
5
Inhibition of Interferon Regulatory Factor 7 (IRF7)-Mediated Interferon Signal Transduction by the Kaposi's Sarcoma-Associated Herpesvirus Viral IRF Homolog vIRF3
... KCl, 1 mM EDTA, 1 mM dithio- threitol, ...7.5), 1 mM EDTA, 50 mM NaCl, 2 mM dithiothreitol, 5% glycerol, ...After 1 h at 100 V, the gel was transferred to nylon (Pierce) ...
11
Human Herpesvirus 8 Encodes an Interferon Regulatory Factor (IRF) Homolog That Represses IRF-1-Mediated Transcription
... however, IRF-2 lacks a strong transactivation domain in its C terminus and acts as an inhibitor of IRF-1-mediated transcrip- ...of IRF-2 deletion mutants to inhibit IRF-1 ...
7
Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3
... of IRF-3 during the early phase of infection may be caused by a block in nuclear export, trapping the shuttling protein IRF-3 in the ...of IRF-3 is mediated by the adaptor protein CRM1 ...type ...
8
Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene ( IRF1 )
... ChIP was performed as described previously [66]. Briefly, 1 × 10 7 cells were fixed in 1% formaldehyde for 10 min followed by the addition of 0.125 M glycine. Cells were lysed using a douncer and the fixed ...
16