IRF-7
Interferon Regulatory Factor IRF-7 Induces the Antiviral Alpha Interferon Response and Protects against Lethal West Nile Virus Infection
... and IRF-7 ⫺/⫺ macrophages, with modestly reduced levels of RIG-I in the latter ...in IRF-7 ⫺/⫺ macrophages, whereas infection-induced levels were compara- ble to those of wild-type ...of ...
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Differential Regulation of Interferon Regulatory Factor (IRF)-7 and IRF-9 Gene Expression in the Central Nervous System during Viral Infection
... of IRF-2 (33), IRF-3 (5), and IRF-9 (14) genes by a wide variety of cell types, while IRF-5 (10) and IRF-7 (6) genes are expressed predominantly by he- matopoietic ...the ...
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Hepatitis C Virus Infection Impairs IRF-7 Translocation and Alpha Interferon Synthesis in Immortalized Human Hepatocytes
... nucleus. IRF-7 amplifies the type I interferon response by inducing expression of IFN- ␣ , which also acts in both autocrine and paracrine manners through the IFN- ␣ /  ...that IRF-7 remains ...
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Differentiation of Neurons Restricts Arbovirus Replication and Increases Expression of the Alpha Isoform of IRF-7
... upregulate IRF-7 ...mRNAs. IRF-3 and IRF-7 are central regulators of the cellular innate immune response and the convergence point for integration of pathogen detection path- ...ways. ...
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Oropouche Virus Infection and Pathogenesis Are Restricted by MAVS, IRF-3, IRF-7, and Type I Interferon Signaling Pathways in Nonmyeloid Cells
... 39). IRF-3- and IRF-7-depen- dent transcription contributes to the control of LACV infection in vivo (40), as their combined deficiency resulted in more rapid death (40, ...
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Use of IRF-3 and/or IRF-7 Knockout Mice To Study Viral Pathogenesis: Lessons from a Murine Retrovirus-Induced AIDS Model
... the IRF-3 gene. Thus, on the basis of comparisons to LP-BM5-infected IRF- 7 ⫺/⫺ and B6 mice, we describe increased MAIDS resistance in infected IRF-3 ⫺/⫺ and certain DKO mice, apparently a ...
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Transcriptional regulation of IFN-λ genes in Hepatitis C virus-infected hepatocytes via IRF-3·IRF-7·NF-κB complex
... Figure 3 IRF-7, and NF- B differentially determine expression of IL-28A/B and IL-29. Nucleotide sequence from 1.0 kb upstream of the transcription start site of human IL-28A, IL-28B, and IL-29. The ...
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Critical Role for Interferon Regulatory Factor 3 (IRF-3) and IRF-7 in Type I Interferon-Mediated Control of Murine Norovirus Replication
... that IRF-3 and IRF-7, as well as signaling through the IFN-␣/R, in- duce an antiviral response that limits dissemination of MNV and/or the replication of the virus in extraintestinal ...lacking ...
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Interferon Regulatory Factor 7 Is Negatively Regulated by the Epstein-Barr Virus Immediate-Early Gene, BZLF-1
... termini. IRF-7 and IRF-3 are the key regulators of the IFN- ␣ /  ...target IRF-7 responses. Endoge- nous IRF-7 expression is normally limited to peripheral lym- phocytes, ...
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Interferon-independent and -induced regulation of Epstein-Barr virus EBNA-1 gene transcription in Burkitt lymphoma.
... the IRF-related cDNAs that we iso- lated in our yeast one-hybrid screen encode a novel protein, IRF-7, that binds specifically to ...level, IRF-7 is most closely related to IRF-3 ...
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Basal and Reovirus-Induced Beta Interferon (IFN-β) and IFN-β-Stimulated Gene Expression Are Cell Type Specific in the Cardiac Protective Response
... Basal IRF-7 expression is higher in PCMCs than in PCFCs, but reovirus induction of IRF-7 is ...PCMCs. IRF-7 was specifi- cally chosen for this experiment because it is an ISG ...
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PKR, Myocarditis and the Cardiac Response to Reovirus Infection
... PCMCs. IRF-7 was specifically chosen for this experiment because it is an ISG solely regulated by ISGF3 (42), and furthermore, because it is critical to the robust amplification of the IFN-β ...of ...
140
High basal expression of interferon stimulated genes in human bronchial epithelial (BEAS 2B) cells contributes to influenza A virus resistance
... of IRF-7 and several ISGs at 24 h of H1N1 virus ...(A) IRF-7, (B) STING (C) ISG15, (D) Mx1, (E) IFN-b and (F) IL-6 was unremarkable in BEAS-2B and NHBE cells; however IRF-7, ...
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Changes in Gene Expression during Pegylated Interferon and Ribavirin Therapy of Chronic Hepatitis C Virus Distinguish Responders from Nonresponders to Antiviral Therapy
... the IRF-7 gene (Tables 4 and 5), a key gene in induction of interferon, was induced compared to baseline at lower levels in poor responders than in marked-response patients, as was the cig 5 (viperin) gene, ...
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Downregulation of IRF-3 Levels by Ribozyme Modulates the Profile of IFNA Subtypes Expressed in Infected Human Cells
... but IRF-3 does not bind to PRDI (11, ...of IRF-3 from infected cells requires two copies of GAAAG/C repeats (unpublished ...The IRF-3 homodimers are functionally active, since IRF-3 can induce ...
7
Intracellular Signaling Molecules Activated by Epstein-Barr Virus for Induction of Interferon Regulatory Factor 7
... of IRF-7, LMP-1 mutants along with a CD4 expres- sion plasmid were transiently transfected into DG75 cells, an EBV-negative cell line, and transfected cells were selected by the use of CD4 antibody ...
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West Nile Virus Noncoding Subgenomic RNA Contributes to Viral Evasion of the Type I Interferon-Mediated Antiviral Response
... whether IRF-3 and IRF-7 are required for induction of the antiviral response that limits repli- cation of sfRNA-deficient ...of IRF-3 ⫺/⫺ ⫻IRF-7 ⫺/⫺ cells with FL-IRA ⌬ CS3 virus ...
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Virus-Activated Interferon Regulatory Factor 7 Upregulates Expression of the Interferon-Regulated BST2 Gene Independently of Interferon Signaling
... single IRF binding site is sufficient to render this promoter responsive to IFN- ␣ ...of IRF-1 or virus-activated forms of IRF-3 and IRF-7 stimulated the BST2 promoter even under ...
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Hantavirus Infection Induces the Expression of RANTES and IP-10 without Causing Increased Permeability in Human Lung Microvascular Endothelial Cells
... Our findings show that SNV and HTN are both able to infect pulmonary HMVECs (HMVEC-Ls) in vitro without affecting detectable levels of the constitutive or (cytokine-) induced expression of endothelial CAMs and do not ...
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Interferon Regulatory Factor 7 Mediates Activation of Tap-2 by Epstein-Barr Virus Latent Membrane Protein 1
... of IRF-7, LMP-1 induced endogenous Tap-2, and ectopic expression of IRF-7 could enhance the ...induce IRF-7, LMP-1 could not induce Tap-2. Addition of IRF-7, which ...
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