Iron accumulation
Psychological stress leads to hepatic iron accumulation and disturbs iron homeostasis
... increased iron concentration was mainly related to the iron uptake of hepatocytes according to hepatic iron ...changed iron distribution and transportation and limited the iron ...
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INFLUENCE OF MANGANESE ON IRON ACCUMULATION BY BACILLUS CIRCULANS
... the iron accumulation capacity of Bacillus circulans in the presence of ...concentrate iron from the different concentrations of iron and manganese containing medium was ...0.2-4.0mM, ...
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Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice
... and iron-retentive signature of microglia in vitro and in transgenic mice that overexpress of amyloid precursor protein (APP) and presenilin 1 (PS1; APP/PS1 mice), a commonly-used animal model of ...and ...
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Gene co expression networks shed light into diseases of brain iron accumulation
... brain iron accumulation, predominantly in the basal ganglia (Kruer et ...in iron metab- olism, but it remains elusive whether other NBIA genes also regulate iron- related processes in the ...
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Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation
... tial accumulation of iron in the ...impaired iron export from the mitochondria, while Mfrn-2 levels are not changed or decreased, possibly as a compensatory response to the increased mitochondrial ...
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An international registry for neurodegeneration with brain iron accumulation
... Increased iron in the brain is reflected by hypointensity on T2-weighted MRI scans, and is typically detected in nuclei where some iron is normally present: GP, SN, putamen, caudate, dentate nuclei and red ...
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Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson’s disease
... Iron accumulation in CP KO mice was most pro- nounced in the liver, which is the major site of CP pro- duction in the ...marked iron elevation at both 5 (~500%, P < ...toward iron eleva- ...
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Mitochondrion-mediated iron accumulation promotes carcinogenesis and Warburg effect through reactive oxygen species in osteosarcoma
... chondrion-mediated iron accumulation increased ROS production in both osteosarcoma cell lines, whereas knock-down of mitoferrin 1 (SLC25A37) and mitofer- rin 2 (SLC25A28) decreased this ...
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Neuroimaging Features of Neurodegeneration with Brain Iron Accumulation
... SUMMARY: NBIA characterizes a class of neurodegenerative diseases that feature a prominent extrapyramidal movement disorder, intellectual deterioration, and a characteristic deposition of iron in the basal ...
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Quantitative Assessment of Iron Accumulation in the Deep Gray Matter of Multiple Sclerosis by Magnetic Field Correlation Imaging
... The mean and SD of the MFC values of the deep gray matter (globus pallidus, putamen, and thalamus) and white matter regions (frontal white matter and splenium and genu of the corpus callosum) in the patients and controls ...
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Methemoglobinemia—A biomarker and a link to ferric iron accumulation in Alzheimer’s disease
... cases, iron deposits were widespread in the brain parenchyma or localized in specific areas showing variable extent and intensity (Figures 4 and ...free iron in the cerebral parenchyma of a patient with ...
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Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver
... transmembrane iron transporter known to be involved in cellular iron ...intestinal iron absorption, erythroid iron utilization, hepatic iron accumulation, placental iron ...
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Looking Deep into the Eye of the Tiger in Pantothenate Kinase–Associated Neurodegeneration
... On T2WI, the eye-of-the-tiger sign with the hyperintense round center was observed in 47 MRIs (63.5% of all MRIs) from 42 patients. Among them, 15 MRIs (mean age at MR imaging, 4.7 years; range, 3 ⬃ 7 years) from 13 ...
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Deferoxamine attenuates lipopolysaccharide-induced neuroinflammation and memory impairment in mice
... and iron accumulation (iron content, Fn and FPN) dur- ing the acute ...brain iron accumulation and a series of inflammatory cascade response, which may be caused by the activation of ...
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Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases
... by iron accumulation and disturb- ance of the IRP-IRE signaling pathway [46, ...of iron chelators, the translation of APP mRNA can be selectively down-regulated [48, ...contrast, iron influx ...
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Review on Iron Overload Disease in Human and Chelating Trap
... free iron in our tissues. The higher unnecessary accumulation and storage space of free iron in body tissues over time can occur with chronic transfusion therapy in patients with ...
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Is There Any Correlation between Migraine Attacks and Iron Deficiency Anemia? A Case-Control Study Migraine Attacks and Iron Deficiency Anemia
... symptoms. Iron accumulation in brain, especially peri-aqueductal grey is associated with duration of the disease, and apparently there is an association between body iron storage status and the ...
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Histological evaluation of daily oral iron administration in anemic rabbits
... daily iron supplementation in treatment of certain types of anemia due to severe shortage of food as well as study the fate of excess iron supplementation within the bodies as chronic iron-overload ...
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The effect of psychological stress on iron absorption in rats
... serum iron level. In our previous study, serum iron level was decreased after 3 d repeated psychological stress exposure before the decline of red cell count and hemo- globin (7 d) ...Perl's iron ...
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Iron-induced Complement Dysregulation in the Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration
... include iron, complement components, and amyloid protein ...that iron may be involved in the pathophysiology of ...by iron in RPE ...for iron-induced C3 ...decreased iron-induced C3 ...
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