Iron and brain
Neuroimaging Features of Neurodegeneration with Brain Iron Accumulation
... biologic iron-oxides, Fe 2⫹ typically has fewer un- paired electrons than Fe 3⫹ and is less effective in quenching T2-weighted signal ...surrounding brain parenchyma, while iron is isointense. In ...
8
Visualization of brain iron by mid field MR
... There are excellent articles describing imaging of brain iron on high-field MR scanners using spin-echo (SE) pulse sequences. These include subarachnoid hemorrhage [6], [r] ...
6
An international registry for neurodegeneration with brain iron accumulation
... Increased iron in the brain is reflected by hypointensity on T2-weighted MRI scans, and is typically detected in nuclei where some iron is normally present: GP, SN, putamen, caudate, dentate nuclei ...
5
Hepcidin, an emerging and important player in brain iron homeostasis
... the brain tips the balance in favor of increased iron-import and cellular iron ...blocking iron-export, further worsens the iron-overload observed in ...from iron- overload due ...
18
Brain Iron Quantification in Mild Traumatic Brain Injury: A Magnetic Field Correlation Study
... excessive iron de- position in ...of brain trauma where diffuse brain he- mosiderin deposits were present even when no gross detection of hemorrhage was identified, 30 and with the demonstrated ...
6
The Potential Value of Iron Oxide Nanoparticlesin Brain Tumor Treatment
... for brain tumors and the poor viral gene expression in brain tumor trials to date has made the study of convection-enhanced delivery and other methods of optimizing the distribu- tion of viruses in the ...
5
Iron Deficiency Decreases dopamine D1 and D2 receptors in rat brain
... of iron in the striatum due to dietary ID was significantly correlated with the decrease in D 2 receptor density; however, this relationship was not apparent in other brain ...several brain regions ...
12
Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Premanifest Huntington Disease
... of iron in other brain regions related to movement and memory, such as the hippocam- pus, substantia nigra, and red nucleus, in subjects with premani- fest ...Decreased iron concentration has been ...
8
Gene co expression networks shed light into diseases of brain iron accumulation
... in brain disease ...distorted iron-overloaded astrocytes (Kruer, 2013) are a core pathological feature in NBIA patients with CP muta- tions, and this gene is in an astrocytic-like ...
11
Assessment of Iron Deposition in the Brain in Frontotemporal Dementia and Its Correlation with Behavioral Traits
... higher iron load in fused in sarcoma and TAR DNA– binding protein subgroups than in those with -frontotemporal lobar ...excessive iron accumulation contributes to neu- rodegeneration, it is not yet clear ...
6
Body Iron Overload is a Determining Factor in Brain Damage in Acute Ischemic Stroke
... Body Iron Overload is a Determining Factor in Brain Damage in Acute Ischemic ...different iron content in the brain tissue before the onset of stroke, iron being involved in the ...
6
The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease
... for iron mishandling in AD brain comes from the histochemical demonstration of non- haem iron deposits in senile plaques [21,92,93] and Aβ plaques in APP mice [94] and iron levels were also ...
19
A novel approach to quantify different iron forms in ex-vivo human brain tissue
... the iron mineralization prod- ucts in the brain, through, their magnetic ...magnetic iron forms are preferable, as this type of iron is complementary to the iron species measured by ...
11
MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping
... of iron by brain ...regional iron concentrations measured in the same young and elderly healthy ...higher iron concentrations in striatal and brain stem ROIs ...in brain stem ...
25
Using superparamagnetic iron oxide nanoparticles to enhance bioavailability of quercetin in the intact rat brain
... Quercetin has high antioxidant potential in comparison with a number of flavonoids and could be used to treat or prevent the development and progression of neurode- generative diseases [28]. Quercetin in combination with ...
12
Abnormal Brain Iron Metabolism in Irp2 Deficient Mice Is Associated with Mild Neurological and Behavioral Impairments
... Abstract Iron Regulatory Protein 2 (Irp2, Ireb2) is a central regulator of cellular iron homeostasis in ...body iron distribution, discrepant results have drawn into question the role of Irp2 in ...
13
Uptake and transcytosis of functionalized superparamagnetic iron oxide nanoparticles in an in vitro blood brain barrier model
... blood brain barrier (BBB). Here we examined the uptake and transcytosis of iron oxide nanoparticles (IONPs) grafted with biomimetic phosphorylcholine (PC) brushes in an in vitro BBB model system, and ...
10
Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study
... the brain, which is known to degrade the tissue micro- structure and consequently changes the MR signal behavior (Dawe et ...with iron concentration as observed in the present study suggests that ...
7
Quantitative Susceptibility Mapping by Inversion of a Perturbation Field Model: Correlation With Brain Iron in Normal Aging
... experiments are impeded by a lack of standardized data sets and open-source implementations of existing QSM techniques. Detailed comparisons of QSIP to L1-QSM were provided for the same human data, however, in addition ...
30
Comparison of histological techniques to visualize iron on paraffin embedded brain tissue of patients with alzheimer's disease
... of iron in the brains of Alzheimer’s disease (AD) patients may facilitate the development of an in vivo magnetic resonance (MR) marker for AD and may cast light on the role of this potentially toxic molecule in ...
9