ischemia-reperfusion
Effect of metoprolol on hepatic ischemia reperfusion injury
... causes ischemia-reperfusion injury in the ...During ischemia period occurs depletion of cellular energy, accumulation of intracellular sodium, calcium, and reactive oxygen species, and activation of ...
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Myocardial ischemia reperfusion injury: a neglected therapeutic target
... The research field of cardioprotection has been plagued by the large number of failed attempts to translate promising therapeutic strat- egies for preventing lethal myocardial reperfusion injury discovered in the ...
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Protective Effect of Ischemic Preconditioning on Hepatic Ischemia Reperfusion Injury in Rats
... Hepatic ischemia/reperfusion can lead to liver cells (i.e., parenchymal and sinusoidal cells) damage and dys- function. Ischemic pre-conditioning is extensively documented to reduce I/R injury in a variety ...
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Effects of Methylprednisolone on the Expression and Activity of Calpain Following Ischemia Reperfusion Spinal Cord Injury in Rats
... after reperfusion, a significant number of calpain-I-positive cells were observed in Groups B and C, as evidenced by the presence of quantities of particles with varying intensities of light yellowish or deep ...
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Inhibition of apoptosis induced by ischemia reperfusion prevents inflammation
... blotting to investigate the effect of I/R on posttransla- tional processing of EMAP-II. Figure 6 shows that I/R results in enhanced cleavage of the 43-kDa EMAP-II precursor as early as 2 hours of reperfusion. The ...
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Immune mechanisms of ischemia reperfusion injury in transplantation
... with reperfusion, are very trouble- some, as ischemia-reperfusion injury (IRI) is de- monstrated to be a major cause of allograft da- mage in various types of ...
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Uterine Reperfusion Ischemia and Use of Elastic Tourniquet
... Introduction: In humans, it has not been established that the use of elastic tourniquet (ET) during myomectomies, whose delivery times do not exceed 90 minutes, which is responsible for ischemia reperfusion ...
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Neuroprotective effect of Buyang Huanwu Decoction on spinal ischemia reperfusion injury in rats is linked with inhibition of cyclin dependent kinase 5
... cord ischemia-reperfusion was induced by using the previously described method ...[5]. Ischemia of the lumbar spinal cord was produced by oc- clusion of the abdominal aorta ...
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Original Article Clusterin (apolipoprotein J) facilitates NF-κB and Bax degradation and prevents I/R injury in heart transplantation
... Aim: Ischemia-reperfusion (I/R) injury is an unavoidable event occurring during heart transplantation and is a key factor in graft failure and long-term survival rate of ...vitro ischemia ...
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Original Article MicroRNA-23 inhibition protects the ischemia/reperfusion injury via inducing the differentiation of bone marrow mesenchymal stem cells into cardiomyocytes
... To evaluate the effect of miR-23 inhibition on alleviating the myocardial ischemia reperfusion injury, the IR animal models were euthanized followed by H&E staining analysis of heart. For comparison, ...
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Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion
... postcapillary venules with reduced (30-50%) shear rates. The increased rolling was also reduced 60% by either an anti-P-selectin antibody, an anti-L-selectin antibody, or a combination of the two antibodies, but this ...
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Integrins protect cardiomyocytes from ischemia/reperfusion injury
... dysfunction, but the role of cell-matrix interactions and integrins in this process has not been extensively studied. Expression of a7b1D integrin, the dominant integrin in normal adult CMs, increases during ...
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TLR4 activation mediates kidney ischemia/reperfusion injury
... Proinflammatory cytokine and chemokine gene expression in primary cultured TECs submitted to 1 hour ischemia in vitro. (A) Immunofluorescence staining of primary cultured TECs from C57BL/6 mice with mAbs against ...
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Aged rat heart: Modulation of age related respiratory defects decreases ischemic reflow injury
... during ischemia and ...during ischemia and reperfusion, sustain ischemic damage to the electron transport chain that is superimposed upon age-related ...before ischemia could de- crease ...
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Reperfusion of Delayed Acute Occlusive Limb Ischemia: Is It Worthwhile?
... limb ischemia more than 12 hours was ...limb ischemia treated between June 2004 and November 2012 were ...with ischemia less than 12 hours, vascular graft occlusion, acute trauma or who refused ...
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Selection of reference genes in different myocardial regions of an in vivo ischemia/reperfusion rat model for normalization of antioxidant gene expression
... Twenty male Wistar rats (8-10 weeks, 250-300 g) were anesthetized by intraperitoneal injection of Zoletil 100 ® + xylazine (50 mg/Kg and 3 mg/Kg respectively). The heart was exposed through a left lateral thoracotomy and ...
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Effect of ischemic preconditioning in skeletal muscle measured by functional magnetic resonance imaging and spectroscopy: a randomized crossover trial
... during ischemia and exercise to 44 ± 13% of the baseline value (Table 1, Figure ...complete reperfusion, the PCr sig- nal recovered quickly, the average time constants are reported in Table ...full ...
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Original Article Investigation of the effects of boron on a renal ischemia/reperfusion injury in rats
... flow. Reperfusion is a new bleeding in a previously ischemic tissue or ...organ. Ischemia/ Reperfusion damage (IRH) is tissue damage that is made by the supply of blood flow to the ischemic ...only ...
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Reperfusion Cellular Injury in an Animal Model of Transient Ischemia
... of ischemia, as well as frank infarction in the striatum and selective neuronal death in the cortex within 30 ...of ischemia or infarction in the frontotemporal lobes and ...III reperfusion), whereas ...
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Original Article Bioinformatics analysis of gene expression profile data to screen key genes involved in cardiac ischemia-reperfusion injury
... cardiac ischemia regions of rats with cardiac ischemia/reperfusion injury were analyzed to identify unique target ...cardiac ischemia/reperfusion ...cardiac ...
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