Ischemia-reperfusion (IR)
Ischemic conditioning by short periods of reperfusion attenuates renal ischemia/reperfusion induced apoptosis and autophagy in the rat
... [20], ischemia/reperfusion injury enhanced both apopto- sis and autophagy production in the rat kidney and con- tributed to renal ...the ischemia/reperfusion model, autophagy and apoptosis are ...
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Ischemia time impacts on respiratory chain functions and Ca2+-handling of cardiac subsarcolemmal mitochondria subjected to ischemia reperfusion injury
... of ischemia reperfusion injury on subsarcolemmal ...with IR influence on mitochondria in ...of ischemia ≥30 min dealt an ex- pected amount of damage with respect to ΔΨm instabil- ity, Ca 2+ ...
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Protective Effect of Ischemic Preconditioning on Hepatic Ischemia Reperfusion Injury in Rats
... against ischemia and reperfusion (I/R) ...(IP), ischemia/reperfusion group (IR) and sham operation group ...liver ischemia/reperfusion was used, in which rats were ...
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<p>Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening</p>
... Figure 1 Protective effect of lycopene (LP) on myocardial ischemia-reperfusion injury. (A) H9c2 cells were pretreated with different concentrations of LP for 12 hrs, which was followed by 12 hr-hypoxia/1-hr ...
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Signaling through hepatocyte vasopressin receptor 1 protects mouse liver from ischemia-reperfusion injury
... liver ischemia-reperfusion injury (IRI) remains ...hepatic IR model, we found terlipressin administration significantly ameliorated IR-induced liver apoptosis, necrosis and ...after IR ...
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Dexmedetomidine attenuates lung apoptosis induced by renal ischemia–reperfusion injury through α2AR/PI3K/Akt pathway
... Renal ischemia–reperfusion (IR) is the major cause of AKI ...[2]. Ischemia AKI rarely occurs in isolation, and often contributes to multiorgan ...
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Pathophysiology of Ischemia/Reperfusion-induced Myocardial Injury: What We Have Learned From Preconditioning and Postconditioning?
... Multiple mechanisms have been postulated for the leukocyte-mediated tissue injury that occurs after ischemia/reperfusion. Microvascular occlusion [ 16], increased vascular permeability [ 17] and release of ...
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Effect of metoprolol on hepatic ischemia reperfusion injury
... hepatic ischemia, is anessential step in liver transplantation and many liver resections (Balzan et ...to ischemia can be worsenby a number of lesions that occur after reperfusion, the so-called ...
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Neuroprotective effect of Buyang Huanwu Decoction on spinal ischemia reperfusion injury in rats is linked with inhibition of cyclin dependent kinase 5
... cord ischemia-reperfusion was induced by using the previously described method ...[5]. Ischemia of the lumbar spinal cord was produced by oc- clusion of the abdominal aorta ...
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The role of HIFs in ischemia-reperfusion injury
... The objective of much research in this area is to find means of reducing infarct size and thereby preserving tissue function after ischemia–reperfusion (I/R) injury. This has involved the investigation of ...
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Targeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia/reperfusion in rats
... Despite advances in research in acute lung injury/acute respiratory distress syndrome (ALI/ARDS), the fundamental basis for ischemia-reperfusion (I/R)-evoked pathophysiology remains unclear. Recently, NAMPT ...
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Original Article Activation of STAT3 is involved in neuronal apoptosis in focal cerebral ischemia/reperfusion rats via Bcl 2/Fas pathway
... cerebral ischemia/reperfusion ...of reperfusion following 3 h of middle cerebral artery occlusion (MCAO), and the neuronal apoptosis were detected by TUNEL ...In ischemia/re- perfusion (I/R) ...
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Original Article Bioinformatics analysis of gene expression profile data to screen key genes involved in cardiac ischemia-reperfusion injury
... There is a complex community of specific mol- ecules in cardiac ischemia regions, and these important genes may profoundly influence many aspects of development for ischemia/ reperfusion (I/R) ...
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Beiras-Fernandez, Andres (2004): Influence of Antithymoglobulins on Ischemia/Reperfusion Injury in perfused non-human primate tissues: Histological and Cytological Investigation. Dissertation, LMU München: Medizinische Fakultät
... Among others, IRI is a major problem in organ transplantation. Polyclonal ATGs are able to block the main cellular features of IRI, including cell activation and release of inflammatory and adhesion molecules. At the ...
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Effects of vagus nerve stimulation on cognitive functioning in rats with cerebral ischemia reperfusion
... Background: Vagus nerve stimulation (VNS) has become the most common non‑pharmacological treatment for intractable drug‑resistant epilepsy. However, the contribution of VNS to neurological rehabilitation following stroke ...
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Effects of hypoglycemia on myocardial susceptibility to ischemia–reperfusion injury and preconditioning in hearts from rats with and without type 2 diabetes
... against IR injury and improved ischemic tolerance in non-preconditioned isolated rat hearts suggesting that increased osmolarity, similar to that in the hyperglycemic conditions, may play a piv- otal role in a ...
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Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation
... of ischemia and hypoxic ventilation, perfusion and room air ventilation were then resumed to initiate the reperfusion ...the reperfusion period by the PULMODYN data acquisition system (Hugo Sachs ...
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Gadolinium decreases inflammation related to myocardial ischemia and reperfusion injury
... tection is dependent upon factors found only in vivo, such as blood cells, proteins or hormones among others. Inflammatory cells are important in the pathophysiologi- cal response to injury associated with IR. ...
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Therapeutic Modalities in Diabetic Nephropathy: Future Approaches
... Wang, et al., “Amelioration of Diabetic Nephropathy DN Incused by Renal Ischemia-Reperfusion IR in Rats with Diabetes Mellitus DM by Treatment with FG-3019, a Monoclonal Antibody Against[r] ...
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Effect of Pioglitazone, Glimepiride and Nebivolol on Renal Marker in Renal Reperfusion Induced Renal Damage in Type 2 Diabetic Rats
... Renal ischemia/reperfusion (I/R) injury is a major cause of acute renal failure (ARF) (2), which is faced in many clinical situations such as kidney transplantation, partial nephrectomy, renal artery, ...
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