Ischemic myocardium
Improvement in Myocardial Function and Coronary Blood Flow in Ischemic Myocardium after Mannitol
... The purpose of this study was to evaluate the effect of hyperosmolality on the performance of, and the collateral blood flow to, ischemic myocardium. The myocardial response to mannitol, a hyperosmolar ...
11
Subendocardial contractile impairment in chronic ischemic myocardium: assessment by strain analysis of 3T tagged CMR
... strain between the two segments. Diagnostic capability of subendocardial C-strain was sensitivity of 77%, speci- ficity of 70%, and accuracy of 74%, and was about equal to that of SPECT. Furthermore, subendocardial ...
8
Early Recovery of Regional Performance in Salvaged Ischemic Myocardium following Coronary Artery Occlusion in the Dog
... protect ischemic myocardium, a critical unanswered question is whether function is preserved in the salvaged ...subendocardial ischemic segments before and after 60 min of left anterior descending ...
16
Accumulation of lysophosphoglycerides with arrhythmogenic properties in ischemic myocardium
... lysophosphoglycerides bound to albumin markedly and reversibly altered action potentials of isolated canine Purkinje fibers in vitro. Changes induced included diminution of the maximum diastolic potential, peak dV/dt of ...
9
The myocardial microcirculation: A key target for salvaging ischemic myocardium?
... the ischemic vascular bed after opening an infarct-related ...include ischemic injury, reperfusion injury, distal vessel embolization and microvessel susceptibility to injury [60]; all of these elements are ...
9
Original Article Cell transplantation into ischemic myocardium using mesenchymal stem cells transfected by vascular endothelial growth factor
... by ischemic heart disease is left ventricular remodeling and myocardial blood supply deficiency caused by scars formed posterior to the infarction, the transplantation of myeloid MCSs transfected with VEGF gene is ...
7
Protective responses in the ischemic myocardium
... Synthesis of HSPs is rapidly induced in response to sev- eral forms of cell stress, including hyperthermia, hypoxia, ischemia, and mechanical stretch applied to cells or intact organs (27). This response requires heat ...
7
Effects of Catecholamines, Exercise, and Nitroglycerin on the Normal and Ischemic Myocardium in Conscious Dogs
... The effects of isoproterenol, norepinephrine, dobutamine, exercise, and nitroglycerin on left ventricular diameter, pressure, velocity of shortening, dP/dt, dP/dt/P, arterial pressure, l[r] ...
14
Autoradiographic characterization of beta adrenergic receptors in coronary blood vessels and myocytes in normal and ischemic myocardium of the canine heart
... Data obtained in this study have demonstrated directly the distribution of beta adrenergic receptors in striated myocytes and blood vessels of the canine heart, and have shown that chang[r] ...
10
Long Term Preservation of Ischemic Myocardium after Experimental Coronary Artery Occlusion
... The results of experiments with indirect methods have suggested that various interventions reduce infarct size after coronary artery occlusion. To determine and quantify directly both the short- and long-term effects of ...
12
Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit Evidence for a role for C5a and interleukin 8
... In b rabbit IL-8 standard cross-hatched bars and reversed phase HPLC fractions containing IL8, retention time 41-42.5 min hatched bar, were added alone or together with anti-rabbit IL-8 [r] ...
10
Altered distribution of lysosomal cathepsin D in ischemic myocardium
... To determine the influence of cardiac ischemia on the activity and subcellular localization of lysosomal cathepsin D, anesthetized rabbits were subjected to ligation of the circumflex coronary artery. Total enzyme ...
12
Targeting delivery of Radix Ophiopogonis polysaccharide to ischemic/reperfused rat myocardium by long-circulating macromolecular and liposomal carriers
... to ischemic myocardium is an enormous ...infarcted myocardium than P 40k ...infarcted myocardium at 3 hours postdose were comparable to P 40k -R, but its level in blood and myocardium ...
9
Low density lipoprotein receptor related protein 1 expression correlates with cholesteryl ester accumulation in the myocardium of ischemic cardiomyopathy patients
... from ischemic cardiomyopathy ...in ischemic human hearts and that LRP1 may be a target to prevent the deleterious effects of myocardial cholesterol accumulation in ischemic ...
11
Fast T2 gradient spin echo (T2 GraSE) mapping for myocardial edema quantification: first in vivo validation in a porcine model of ischemia/reperfusion
... Accurate noninvasive detection and quantification of myocardial edema is of great scientific and clinical inter- est given the occurrence of edema in several cardiovas- cular diseases and its usefulness for diagnosis and ...
9
CoQ10 enhances PGC1α and increases expression of mitochondrial antioxidant proteins in chronically ischemic swine myocardium
... ischemic myocardium that remains viable despite re- duced blood flow and regional function at ...hibernating myocardium (HM), and is an at- tractive target for novel therapies due to the presence of ...
10
Insulin like growth factor 1 protects ischemic murine myocardium from ischemia/reperfusion associated injury
... the ischemic myocardium was sup- ported by histologic evidence of improved tissue and cellular integrity, including markedly less interstitial edema around the perivascular ...model, ischemic ...
8
No hypoperfusion is produced in the epicardium during application of myocardial topical negative pressure in a porcine model
... normal myocardium, while a TNP of -125 mmHg did not significantly alter the microv- ascular blood ...normal myocardium during TNP. In ischemic myocardium, application of a TNP of -50 mmHg over ...
7
Original Article Hydrogen sulfide improves cardiomyocytes electrical remodeling post ischemia/reperfusion injury in rats
... Abstract: Hydrogen sulfide (H 2 S), produced by cystanthionine-γ-lysase (CSE) in the cardiovascular system, is an endogenous gaseous mediator exerting pronounced physiological effects as the third gasotransmitter in ...
8
Electrophysiological Mechanisms of Ventricular Fibrillation Induction
... causing ischemic myocardium, many VF induction studies have demonstrated that the VFT was decreased when the degree of dispersion of refractoriness ...
8