Islet cells
Histomorphological and morphometric studies of the pancreatic islet cells of diabetic rats treated with extracts of Annona muricata
... Streptozotocin-induced hyperglycaemia in rats is considered a good model for the preliminary screening of agents active against type 2 diabetes [23] and is widely used. Generally, destruction of b-cells starts ...
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Binding and internalization of somatostatin, insulin, and glucagon by cultured rat islet cells
... A cells, 125I-insulin in A and D cells, and 125I-glucagon in B and D cells were rapidly transferred from endocytotic vesicles to lysosomal ...D cells, 125I-insulin in B cells, and ...
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A preliminary analysis of hepatitis C virus in pancreatic islet cells
... In this pilot study, infection in pancreatic islets was demonstrated using multiple complementary assays, including qualitative strand-specific RT-PCR for HCV RNA and quantitative ELISA for two HCV proteins. HCV ...
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Large scale isolation, growth, and function of porcine neonatal islet cells
... b cells were capable of secreting significant amounts of insulin in response to a glucose ...for islet cells prepared from the neonatal pig pancreas (1–3 d old) after trypsin dissociation and 7-d ...
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Heat shock induces resistance in rat pancreatic islet cells against nitric oxide, oxygen radicals and streptozotocin toxicity in vitro
... induced islet cell death, was suppressed after heat shock (P < ...pancreatic islet cells can rapidly activate defence mechanisms against nitric oxide, reactive oxygen intermediates and ...
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Cyclic adenosine monophosphate prevents the glucocorticoid mediated inhibition of insulin gene expression in rodent islet cells
... single islet cells, as in HIT-15 cells, but does not affect these levels in reaggregated islet cells and increases them in intact islets of ...beta cells, we investigated whether ...
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Production and characterization of a cytotoxic monoclonal antibody reacting with rat islet cells
... rat islet tumor cells (RINm clone 5F and RINm clone 14B) and normal rat islet ...tumor cells as well as A, B, and D pancreatic polypeptide rat islet ...thymus cells, pancreatic ...
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Intravital imaging of CTLs killing islet cells in diabetic mice
... Supplementation with TCR transgenic effectors results in a consistent synchronization of hyperglycemia onset as compared with the conven- tional model. (C) 2-Photon imaging was successful in capturing β cell mass and ...
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Dynamic oscillations in the membrane potential of pancreatic islet cells
... B1G, 00 Parameter which determines the steady-state value of the base-line and silent phase rate of passive potassium flow as a function of glucose concentration s - 1.. See equation 15.[r] ...
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Original Article Osteoprotegerin promotes islet β cell proliferation in intrauterine growth retardation rats through the PI3K/AKT/FoxO1 pathway
... increased islet macrophage infiltration and impaired function ...the islet cells or an effect resulted from different doses of OPG intake (1 µg/mouse in Toffoli et ...
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Regenerating islet-derived protein 1 inhibits the activation of islet stellate cells isolated from diabetic mice
... regenerating islet cells following a near total pancreatectomy [29, ...and islet regeneration [31, 32], and exogenous Reg1 protein has mitogenic effects on ductal cells and β-cells [33, ...
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Pancreatic neurogenin 3 expressing cells are unipotent islet precursors
... Average islet volume increases with age (n4-5 mice per group, with 800-1200 islets scored per group; ...of islet size from 2- and 10-month-old mice (n5 mice per group; 60,000-150,000 islet ...
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Prevention of diabetes in BB/Wor rats by intrathymic islet injection
... induce islet thymic tolerance may be an etiological factor in the development of the ...induce islet tolerance and thus prevent ...of islet cells by spleen cells from nondiabetic ...
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Microenvironmental stimuli for proliferation of functional islet β-cells
... between cells and ECM are known to regulate several philological aspects including: survival [100], proliferation [101], and insulin secretion in islets ...tissue, cells synthesize ECM components and ...
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Immunohistochemical and morphometric study of the effect of maternal diabetes on rat foetal pancreatic islets
... of islet cells, which are caused by the stimulatory effect of hyperglycaemia present in the diabetic foetal ...foetal islet B, A and PP cells of diabetic mothers show ...stem cells, ...
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Association of insulin, C-peptide and blood lipid patterns in patients with impaired glucose regulation
... of islet cells increase with normal islet cell structure and gene expression, which can be designated as the islet cell functional compensatory ...the islet cell to glucose stimulation ...
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Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution
... 2354 cells were sequenced and classified into appropriate cell types based on the gene expression of known markers: acinar cells, islet and ductal cells (Supplemental Figure 2), macrophages, T ...
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Pancreatic β- and α-cell adaptation in response to metabolic changes
... for islet function (12), insulin protein content (6) or insulin gene expression ...human islet cells is the multiparameter high-throughput screening by Hill et ...of islet function. In this ...
145
The Role of Arx in Specification and Maintenance of Pancreatic Islet α-Cells
... pancreatic islet cells is an intricate ...For islet glucagon-producing alpha- cells one such transcription factor is the aristaless-related homeobox gene ...the islet alpha-cell as well ...
166
Human mesenchymal stem cells improve rat islet functionality under cytokine stress with combined upregulation of heme oxygenase-1 and ferritin
... of islet cells from MSCs, MSCs were stained with PKH67 before seeding islets, accord- ing to the manufacturer’s instructions (Sigma-Aldrich, ...rotic cells. Cells labelled with PI and PKH67 ...
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