isolated rat hearts
Dexmedetomidine enhances tolerance to bupivacaine cardiotoxicity in the isolated rat hearts: alpha 2 adrenoceptors were not involved
... Forty isolated rat hearts were mounted on the Langen- dorff system and then randomly assigned to 5 groups ...the hearts in all groups until the ...
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Original Article Effects of hydromorphone postconditioning on ischemia-reperfusion injury in isolated rat hearts and mitochondial permeability transition pore
... in isolated rat hearts and mitochondial permeability transition pore ...SD rat hearts were harvested and then perfused in a Langendorff apparatus with K-H solution ...saturate. ...
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<p>The Effect of Sertraline on Hemodynamic Parameters and Nitric Oxide Production in Isolated Rat Hearts Subjected to Ischemia and Reperfusion</p>
... on isolated rat hearts. Hearts from three groups were perfused with sertraline at three different concentrations and subjected to global ischemia and ...reperfusion. Hearts from the ...
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Ischemic preconditioning stimulates sodium and proton transport in isolated rat hearts
... pathways, isolated rat hearts were subjected to 30 min of global ischemia with or without ...the hearts to an acid load (NH4Cl ...preconditioned hearts (P < ...
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Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts
... on Isolated Rat Hearts. The extracts and isolated compounds were screened for their cardiovascular effects in isolated perfused rat hearts by using the Langendorff-perfused ...
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5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts
... treated hearts, coronary flow- increasing effect of 5-HT was suppressed by TEA ...L-NAME-treated hearts did not likely come from blocking small- and/or intermediate-conductance Ca 2+ -activated K + ...
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Changes in citric acid cycle flux and anaplerosis antedate the functional decline in isolated rat hearts utilizing acetoacetate
... Whereas hearts perfused with either acetoacetate or glucose were similar with respect to their function for the first 20 min, changes in tissue metabolites were already observed within 5 min of perfusion at ...
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Low molecular weight iron and the oxygen paradox in isolated rat hearts
... normal hearts during ischemia and to iron-loaded hearts during anoxia and ...normal hearts a progressive 30-fold increase occurs in low molecular weight iron after 45 min of ischemia, whereas (b) ...
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<p>Impact of Administration Time and Kv7 Subchannels on the Cardioprotective Efficacy of Kv7 Channel Inhibition</p>
... the isolated rat hearts, nor did inhibition with Chromanol 293B and HMR1556 increase HL-1 cell ...the rat heart and only weak expression of ...
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Original Article Morphine postconditioning protection against reperfusion injury: PKC epsilon and extracellular signal-regulated kinase 1 and 2
... protects isolated rat hearts against ischemia-reperfusion injury via the recruitment of the PKCε-ERK1/2 signal- ing pathway, and provides new insight into the post-receptor signal transduction ...
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Inhibition of Aldehyde Dehydrogenase 2 by Oxidative Stress Is Associated with Cardiac Dysfunction in Diabetic Rats
... in isolated rat hearts from control (Con), untreated diabetic (Dia), diabetic treated with NAC (NAC) and diabetic treated with α -LA ( α -LA) ...in isolated heart mitochondria from control or ...
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Perfusion independent oxygen extraction in myoglobin rich hearts
... Myoglobin-rich sea raven hearts and myoglobin-poor ocean pout hearts were isolated and perfused at varying flow rates and under conditions of low and high oxygen demand to assess the rol[r] ...
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Remote preconditioning in normal and hypertrophic rat hearts
... In laboratory studies, pressure overload induced car- diac hypertrophy has been shown to be associated with a greater susceptibility to ischemic/reperfusion injury in comparison to normal hearts. A number of ...
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Forced expression of the cell cycle inhibitor p57Kip2 in cardiomyocytes attenuates ischemia-reperfusion injury in the mouse heart
... Total RNA was isolated from control and mutant adult hearts by Trizol (Invitrogen, Carlsbad, CA) extraction. The PCR reactions were performed with the 7500 RT-PCR sys- tem (Applied Biosystems, Foster City, ...
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Identification in vitro of an endothelial cell surface cofactor for antithrombin III Parallel studies with isolated perfused rat hearts and microcarrier cultures of bovine endothelium
... Platelet factor 4, protamine sulfate and diisopropylphosphoryl thrombin, all antagonists of the antithrombin III cofactor activity of heparin, significantly reduced the capacity of the p[r] ...
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Myosin ATPase activity of muskrat, guinea pig and rat hearts
... Total citrate synthase activity was determined in heart muscle homogenate of five rats, four guinea pigs and five muskrats using the method of Shepard and Garland 1969.. This study shows[r] ...
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Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion
... upstream MAPK kinase 4 phosphorylation, following ischemia/reperfusion. These effects were reversed if recombinant MIF was present during reperfusion, indicating that MIF deficiency during reperfusion exacer- bated ...
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Micro Computed Tomography Provides Accurate Measurement for Cardiac Function in Infarcted Rat Heart
... The initial disk images of the normal rat heart obtained by CT are shown in Figure 1. Panels on the left (Figure 1(a), Figure 1(c)) are plane images, and panels on the right (Figure 1(b), Figure 1(d)) are the ...
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Studies of Isolated Fetal Mouse Hearts in Organ Culture: EVIDENCE FOR A DIRECT EFFECT OF TRIIODOTHYRONINE IN ENHANCING CARDIAC RESPONSIVENESS TO NOREPINEPHRINE
... triiodothyro-nine-treated or control medium. After 2 days, however, the curve was shifted to the left in triiodothyronine-treated hearts. Thus, 10 −8 m norepinephrine increased the atrial rate by 20±6.1 (sem) ...
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Coenzyme A sequestration in rat hearts oxidizing ketone bodies
... in rat hearts is due to inhibition of 2-oxoglutarate dehydrogenase, and it has been speculated that this inhibition is due to the sequestration of intramitochondrial CoA as acetoacetyl-CoA and ...by ...
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