Isoniazid resistance
Validation of the FluoroType MTBDR Assay for Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Complex Isolates
... drug resistance is crucial to ensure early initiation of appropriate ther- ...and isoniazid resistance has become ...to isoniazid and rifampin, 7 with isoniazid monoresistance, 7 with ...
6
Original Article Genome-wide SNP and InDel mutations in Mycobacterium tuberculosis associated with rifampicin and isoniazid resistance
... tuberculosis resistance against major anti-TB agents including INH and RIF [5, ...the resistance of TB against INH has been mainly mediated by genetic mutations in several genes including katG, inhA and ...
16
Genotypic Detection of rpoB and katG Gene Mutations Associated with Rifampicin and Isoniazid Resistance in Mycobacterium Tuberculosis Isolates: A Local Scenario (Kelantan)
... and drug susceptibility testing of TB is time consuming. TB diagnosis using standard culture techniques, even in the presence of automated fluid culture methods, takes an average of 14 days to complete (14). This ...
5
Diagnostic Accuracy and Utility of FluoroType MTBDR, a New Molecular Assay for Multidrug Resistant Tuberculosis
... conferring resistance to rifampin and isoniazid irrespective of smear ...and isoniazid resistance was observed, a higher indeterminate rate was observed for MTBDRplus for the detection of ...
13
Latent Tuberculosis Infection in Children: A Call for Revised Treatment Guidelines
... of isoniazid, is both more expensive and less effective than ...of isoniazid resistance exceeds ...drug resistance in high-risk individuals such as children who are internationally adopted, ...
9
Pyrosequencing for Rapid Detection of Mycobacterium tuberculosis Resistance to Rifampin, Isoniazid, and Fluoroquinolones
... and isoniazid resistance testing in clinical practice an average of 19 days earlier than the conventional method, with sensitivities of ...quinolone resistance would be expected to have an even ...
6
The molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosis
... that isoniazid blocks the synthesis of cell-wall mycolic acids, the major components of the envelope of M tuberculosis ...low-level resistance to isoniazid (for review ...for isoniazid resis- ...
5
GeneChip analysis of resistant Mycobacterium tuberculosis with previously treated tuberculosis in Changchun
... Based on the data shown in Table 1, RFP and INH mono-resistance positivity rates were 26.5% (178/671) and 26.4% (177/671), respectively, according to the DNA microarray method; these rates were slightly lower than ...
8
Use of a Mycobacteriophage Based Assay for Rapid Assessment of Susceptibilities of Mycobacterium tuberculosis Isolates to Isoniazid and Influence of Resistance Level on Assay Performance
... to isoniazid based on mycobacteriophage amplification ...The isoniazid resistance molecular mechanism was previously deter- mined by sequencing the entire katG gene and the mabA-inhA regulatory ...
5
Analysis of gene mutations associated with isoniazid, rifampicin and ethambutol resistance among Mycobacterium tuberculosisisolates from Ethiopia
... EMB resistance Mutations conferring resistance to isoniazid, rifampicin and ethambutol were detected in 14%, 6% and 3% of the isolates, ...with isoniazid resistance were more often ...
7
INACTIVATION AND MUTATIONS IN MYCOBACTERIUM AVIUM BY DECAY OF INCORPORATED RADIOACTIVE PHOSPHORUS
... The incidence of mutation (to isoniazid resistance) did not parallel the amount of total radioactivity of cells that corresponded to the amount of beta-ray irradia- tion. T[r] ...
14
Mutations in Codon 315 of the katG Gene Associated with High-level Resistance to Isoniazid
... to isoniazid (Table 1). All isoniazid resistance isolates studied had mutations of different types in katG ...42 isoniazid resistance isolates 10 (24%, Table 3) were from sputum of ...
9
"MULTI DRUG RESISTANT TUBERCULOSIS (MDR-TB) - TUBERCULOSIS RESISTANT TO POWERFUL FIRST LINE ANTI TB DRUGS: A REVIEW " By Raghvendra*, Satyanand Tyagi, Pramod Yadav, Sunanda Saxena, Rajesh A. Dodia, Tanvi D. Patel, India.
... RMP resistance is rare (except when patients have a history of being treated with rifampicin ...though isoniazid resistance so commonly occurs with rifampicin ...
5
Global and Regional Burden of Isoniazid-Resistant Tuberculosis
... as the explanatory variable. We weighted the regression by the number of child cases in each study with drug susceptibility test results and calculated robust standard errors to allow for the potential impact of multiple ...
12
Detection of Mutations Associated with Isoniazid and Rifampin Resistance in Mycobacterium tuberculosis Isolates from Samara Region, Russian Federation
... to isoniazid, whereas isolates with mutant genotypes at either or both of these loci were interpreted as being resistant to ...of isoniazid-resistant isolates and ...
5
Original Article Comparison of genotype MTBDR plus results between TB patients with different levels of drug resistance: a retrospective study in China
... of resistance, but only 17% of the strains are char- acterized by a low level of INH ...INH resistance is designed to detect only one mutation in katG and three in ...
6
Multiplex Real Time PCR Melting Curve Assay To Detect Drug Resistant Mutations of Mycobacterium tuberculosis
... drug resistance-related regions and detect mutations on the basis of the melting curve analysis of the probes at the end of PCR ...each resistance mutation not only increases the costs but also limits these ...
7
Predictive Value of Molecular Drug Resistance Testing of Mycobacterium tuberculosis Isolates in Valle del Cauca, Colombia
... detect resistance to antituberculosis drugs has become an impor- tant tool in the fight against MDR-TB and ...drug resistance in at-risk ...increasing resistance, which has been correlated with high ...
5
Systematic Molecular Characterization of Multidrug Resistant Mycobacterium tuberculosis Complex Isolates from Spain
... Tuberculosis (TB) remains one of the infectious diseases responsible for the most adult deaths in the world because of the lack of access to effective and rationally delivered therapy for drug-susceptible TB. Spain has ...
8
Factors associated with isoniazid resistant tuberculosis among human immunodeficiency virus positive patients in Swaziland: a case control study
... rifampicin resistance. If MTB positive and ri- fampicin resistance not detected, the patient is assumed to be having drug susceptible TB (DS-TB), then the pa- tient is initiated on DS-TB ...rifampicin ...
8