isoprenoid biosynthesis
Divergent Isoprenoid Biosynthesis Pathways in Staphylococcus Species Constitute a Drug Target for Treating Infections in Companion Animals
... that isoprenoid bio- synthesis differs between Staphylococcus ...targeting isoprenoid biosynthesis is not a viable strategy to treat staphylococcal bacterial infections in humans or other ...
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Isoprenoid Biosynthesis Inhibition Disrupts Rab5 Localization and Food Vacuolar Integrity in Plasmodium falciparum
... of isoprenoid bio- synthesis in malaria parasites and are consistent with findings re- ported previously by Yeh and DeRisi (unpublished data described in ...novo isoprenoid biosynthesis, since ...
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An Account of Cloned Genes of Methyl-erythritol-4-phosphate Pathway of Isoprenoid Biosynthesis in Plants
... Many pathogenic microorganisms including Mycobacterium tuberculosis and Plasmodium falciparum also operate MEP pathway for the biosynthesis of isoprenoids. In fact, isoprenoids plays crucial role in the survival ...
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Modulation of Hepatitis C Virus RNA Abundance and the Isoprenoid Biosynthesis Pathway by MicroRNA miR-122 Involves Distinct Mechanisms
... Our findings suggest that miR-122 does not affect HCV RNA abundance directly through the mevalonate pathway. It remains possible that miR-122 could regulate HCV RNA abundance in the intact liver through other effects on ...
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Isoprenoid Biosynthesis in Plasmodium falciparum
... therapies. Isoprenoid synthesis via the methylerythritol phosphate (MEP) pathway represents an attractive target for the development of new ...of isoprenoid biosynthesis in ...Recently, ...
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Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells
... the isoprenoid biosynthetic pathway (IBP) causes a block in MP secretion through a disruption of Rab GTPase activity, leading to an enhanced unfolded protein response and subsequent apoptosis in MM ...of ...
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Mevalonate kinase deficiency: current perspectives
... MKD represents a broad range of disease phenotypes, with HIDS and MA located on either end of the severity spectrum. These entities lack homogeneity in both genotypic and phe- notypic expression, and there remains ...
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In silico identification of putative drug targets of chlamydia psittaci 6bc by subtractive genome approach
... In the current study, we have utilized subtractive genomic approach based on various bioinformatics centered databases and computational tools in order to identify essential non- homologous drugable proteins against C. ...
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NOVEL ANTIMALARIAL AGENTS AND TARGETS: AN OPTIMISM OVER RESISTANCE
... Malaria is a complex disease with ample of host–parasite interactions. Due to long terminal elimination half-life, a shallow concentration-effect relationship, and mutations a drug becomes vulnerable to resistance ...
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Engineering Pseudomonas putida for isoprenoid production by manipulating endogenous and shunt pathways supplying precursors
... for isoprenoid biosynthesis could be improved by increasing the avail- ability of both GAP and pyruvate or by finding alternative sources for DXP ...
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Systems-Level Analysis of Oxygen Exposure in Zymomonas mobilis: Implications for Isoprenoid Production
... enhance isoprenoid production in microorganisms has therefore become a growing area of ...for isoprenoid biosynthesis: the mevalonate pathway, used in archaea and the cytosol of eukaryotes, and the ...
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Efficient Production of δ Guaiene, an Aroma Sesquiterpene Compound Accumulated in Agarwood, by Mevalonate Pathway Engineered Escherichia coli Cells
... Mevalonate pathway for isoprenoid biosynthesis was constructed in Escherichia coli cells by the transformation with a gene cluster isolated from Streptomyces sp., and farnesyl diphosphate synthase and δ ...
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Improving squalene production by enhancing the NADPH/NADP+ ratio, modifying the isoprenoid-feeding module and blocking the menaquinone pathway in Escherichia coli
... General molecular manipulations were performed according to standard protocols [44]. For expression of hsqs, the hsqs gene was excised from pUC57-hsqs using NcoI and KpnI, then ligated into plasmid pTrc99A cut with the ...
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An insight into new strategies to combat antifungal drug resistance
... lose biosynthesis and sphingolipids biosynthesis, in an attempt to provide clinical evidence for overcoming drug resistance and to form the rationale for combination therapy of conventional antifungals and ...
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Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL 60 cells
... lovastatin as inhibitors of the isoprenylation pathway. Treatment of DMSO-differentiated HL- 60 cells with compactin produced a concentration-dependent inhibition of O2- formation in response to FMLP or phorbol myristate ...
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Biogenic isoprenoid emissions under drought stress: different responses for isoprene and terpenes
... of isoprenoid emissions of a specific forest ecosystem will be reflected by the individual contribution of tree species and their specific emission pat- terns, and the sum of SM affects the drought sensitivity of ...
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Cellular fatty acid compositions and isoprenoid quinone contents of 23 Legionella species
... as the major acid at concentrations approximately twice that of Cj16:0 were designated as the A15 group Table 2; and the remaining seven species, which contained both Cal5 0 and Cj16:0 a[r] ...
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Immunomodulatory synergy by combination of atorvastatin and glatiramer acetate in treatment of CNS autoimmunity
... Several criteria should be considered when selecting immunomodulatory agents for use in combination therapy for MS: (a) medications should have complementary activities, preferentially acting through different mechanisms ...
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Microbial Exopolysaccharides: Biosynthesis and Potential Applications
... EPS biosynthesis are classified into 2 ...the biosynthesis of EPS and not specific for ...(EPS) biosynthesis gene clusters of four Lactobacillus rhamnosus strains consist of chromosomal DNA regions ...
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Oberwinkler, Tanja Margret (2011): Metabolic and genomic annotations in halophilic archaea. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Glycolipids of halophilic archaea are generally multifarious and the biosynthesis of them is not understood at all (Morii & Koga, 2003; Koga & Morii, 2007). In general it is known that in extreme ...
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