JAK/STAT
Evidence for Tissue-Specific JAK/STAT Target Genes in Drosophila Optic Lobe Development
... single JAK kinase Hopscotch (Hop), and a single STAT protein STAT92E (Arbouzova and Zeidler ...The JAK/STAT pathway plays a wide range of roles in Drosophila development, including embryonic ...
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A Determinant of Sindbis Virus Neurovirulence Enables Efficient Disruption of Jak/STAT Signaling
... of Jak/STAT signaling plays in alphavirus pathogenesis, we eval- uated whether viruses with differing virulence profiles exhib- ited the ability to inhibit Jak/STAT ...of Jak proteins ...
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Modulation of human JAK-STAT pathway signaling by functionally conserved regulators
... One of the key aspects of the STAT1 and STAT3 transcrip- tional assay development was the decision to avoid transiently transfected reporter assays in preference for the direct measure- ment of pathway target gene mRNA ...
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JAK-STAT Signaling Pathways and Inhibitors Affect Reversion of Envelope-Mutated HIV-1
... of JAK-STAT signaling pathways caused the inhi- bition of such cell-to-cell infection as well as the reversion of multiple HIV Env mu- tants that displayed differences in their abilities to bind to the CD4 ...
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Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak Stat signaling and inhibits HCV RNA replication
... The mechanism of IFN-a resistance has been described to be related to several viral and host related factors [9-11]. For this purpose, we have developed mul- tiple IFN-a resistant cell lines containing sub-genomic HCV ...
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miR 19a: an effective regulator of SOCS3 and enhancer of JAK STAT signalling
... Since miR-19a reduced SOCS3 mRNA and luciferase activity, we next examined its functional effect on SOCS3 protein and downstream signalling induced by IFN-α and IL-6, known to be regulated by SOCS3 [8,9]. Upon expression ...
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JAK/STAT signaling in stem cells and regeneration: from Drosophila to vertebrates
... the JAK/STAT pathway. Under normal conditions, JAK/STAT ligands are produced at variable levels by several intestinal cell ...transduce JAK/STAT signals can proliferate, ...
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Inhibition of Interferon-Stimulated JAK-STAT Signaling by a Tick-Borne Flavivirus and Identification of NS5 as an Interferon Antagonist
... of JAK-STAT signaling in infected primary ...inhibits JAK-STAT signaling, then not only virus replication but also immune regulation may be ...shown). JAK-STAT signaling is ...
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CP690,550 inhibits oncostatin M induced JAK/STAT signaling pathway in rheumatoid synoviocytes
... the JAK/STAT pathway with in vitro activity in rheumatoid synoviocytes consistent with in vitro enzyme ...that JAK/STAT activation play a pivotal role in OSM- mediated IL-6 up-regulation in ...
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Localised JAK/STAT Pathway Activation Is Required for Drosophila Wing Hinge Development
... the JAK/STAT pathway are expressed in this domain in os o ...and JAK/STAT pathway activity in os o mutants described above, fate mapping experiments have previously identified the AS1 as being ...
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The Activity of JAK/STAT and NF-κB in Patients with Rheumatoid Arthritis
... it STAT proliferation and differentiation, and the JAK/STAT ...promote STAT-re- sponsive gene ...multiple JAK/STAT pathways, which may inhibit cell proliferation and differ- ...
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Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen
... in JAK/STAT signaling, but dally apparently plays a more significant role at this ...of JAK/STAT ...for JAK/STAT signaling in the ovary, though they might contribute in other ...
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JAK/STAT autocontrol of ligand producing cell number through apoptosis
... Whereas in the control, PC number was almost always two from stage 7, targeted expression of dome and hop RNAi with fru-Gal4 led to the production of late-stage follicle poles with three to five PCs (Fig. 5I,J). At later ...
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HSP90 is essential for Jak-STAT signaling in classical Hodgkin lymphoma cells
... Recently, HSP90-inhibitors geldanamycin and its deriva- tive 17-AAG have been shown to have anti-proliferative effects, sensitize for apoptotic stimuli and synergize with chemotherapy regimens in cHL cell lines [4,5]. It ...
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Feifukang ameliorates pulmonary fibrosis by inhibiting JAK STAT signaling pathway
... High-throughput technologies revealed that only 2% of the transcribed genome codes are attributed to proteins. With the wide-scale adoption of high-throughput sequen- cing techniques, these noncoding RNAs were described ...
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Requirement for JAK/STAT signaling throughout border cell migration in Drosophila
... the JAK/STAT signaling pathway in Drosophila are a secreted ligand called UPD, its receptor, called Domeless (DOME), a JAK, referred to as HOP, and STAT92E ...or stat in the border cells ...
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JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions
... Similar gain-of-function mutations in the Drosophila JAK homologue HOP have also been identified. The hop T42 allele, for example, also contains a pseudo-kinase domain mutation, which leads to the constitutive ...
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JAK/STAT signalling mediates cell survival in response to tissue stress
... whether JAK/STAT signalling is sufficient to induce developmental delays, we expressed the JAK/STAT-ligands Upd1 or Upd2 in wild-type discs using ...to JAK/STAT signalling ...
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Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats
... Because JAK/STAT signaling is induced by IL-6, the recorded down-regulation could be attributed to the anti-inflammatory effect of ...the JAK/STAT signaling pathway can decrease the synthesis ...
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Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application
... embryogenesis. JAK family contains four cytoplasmic tyrosine kinases, JAK1-3 and ...Seven STAT proteins have been identified in human cells, STAT1-6, including STAT5a and ...of JAK – STAT ...
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