JAK-STAT signaling
Acteoside inhibits inflammatory response via JAK/STAT signaling pathway in osteoarthritic rats
... via JAK/STAT signaling ...that JAK/STAT signaling pathway was enhanced by IL-1β stimulation in primary chondrocytes, and ACT could inhibit the JAK/STAT ...
8
Requirement for JAK/STAT signaling throughout border cell migration in Drosophila
... reduced STAT activity (dome mosaic clones, overexpression of dominant-negative Dome, and overexpression of SOCS) lead to disruptions of cluster formation (Ghiglione et ...that JAK/STAT ...
10
Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak Stat signaling and inhibits HCV RNA replication
... the Jak-Stat signaling ...defective Jak-Stat signaling and to induce an antiviral state in the IFN-a resistant replicon cell line by developing a chimera IRF9 protein fused with ...
12
HSP90 is essential for Jak-STAT signaling in classical Hodgkin lymphoma cells
... Recently, HSP90-inhibitors geldanamycin and its deriva- tive 17-AAG have been shown to have anti-proliferative effects, sensitize for apoptotic stimuli and synergize with chemotherapy regimens in cHL cell lines [4,5]. It ...
5
JAK STAT signaling in asthma
... the Jak-Stat signaling cascade discussed else- where in this Perspective ...this signaling path- way, binding of a cytokine to its receptor leads to the activation of members of the JAK ...
6
JAK/STAT signaling in stem cells and regeneration: from Drosophila to vertebrates
... 2017). JAK/STAT signaling is also crucial for the regeneration of diverse zebrafish cells and tissues, including cardiomyocytes, the retina and inner ear hair cells (Fang et ...2014). ...
13
A Determinant of Sindbis Virus Neurovirulence Enables Efficient Disruption of Jak/STAT Signaling
... of Jak/STAT signaling plays in alphavirus pathogenesis, we eval- uated whether viruses with differing virulence profiles exhib- ited the ability to inhibit Jak/STAT ...of Jak ...
11
Inhibition of Interferon-Stimulated JAK-STAT Signaling by a Tick-Borne Flavivirus and Identification of NS5 as an Interferon Antagonist
... of JAK-STAT signaling in infected primary ...inhibits JAK-STAT signaling, then not only virus replication but also immune regulation may be ...shown). JAK-STAT ...
12
JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila
... Drosophila JAK/STAT ...that JAK/STAT signaling promotes formation of the eye field through repression of wg gene transcription in both the dorsal and ventral halves of the eye disc ...
9
Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats
... Because JAK/STAT signaling is induced by IL-6, the recorded down-regulation could be attributed to the anti-inflammatory effect of ...the JAK/STAT signaling pathway can decrease ...
13
DNA methylation controls the timing of astrogliogenesis through regulation of JAK STAT signaling
... the STAT cis-element within the Gfap promoter blocks STAT3 association (Takizawa et ...the STAT-binding element attenuates phospho STAT1 (pSTAT1) and the STAT 1/3 complex from associating with the ...
12
MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer
... stated, JAK-STAT activation stimulates cell proliferation as well as other processes that contribute to metastasis, and unchecked stimulation of this pathway may lead to uncontrolled cell ...such, ...
15
JAK-STAT Signaling Pathways and Inhibitors Affect Reversion of Envelope-Mutated HIV-1
... of JAK-STAT signaling pathways caused the inhi- bition of such cell-to-cell infection as well as the reversion of multiple HIV Env mu- tants that displayed differences in their abilities to bind to ...
15
Feifukang ameliorates pulmonary fibrosis by inhibiting JAK STAT signaling pathway
... molecular signaling pathway remains intractable because the potential targets and active substances of herbs are difficult to identify and analyze [37, ...and signaling pathways in FFK treatment were ...
13
Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen
... stage, JAK/STAT signaling and Upd protein persist in a ...4. JAK/STAT activity is decreased in dally mutant ...activated STAT in wild-type ovaries (A,C) than in Hs2st mutants ...
10
JAK/Stat signaling regulates heart precursor diversification in Drosophila
... Notch signaling pathway, which acts through E(spl)-C genes to restrict twi expression (Tapanes-Castillo and Baylies, ...Notch signaling appears to be active throughout the mesoderm after ...segmented ...
12
JAK/STAT signaling and human in vitro myogenesis
... that STAT signaling during myogenesis is similar in humans as to what has been described in ...of JAK/ STAT signaling in human skeletal myogenesis; further mechanistic investigation is ...
7
Genomic analysis reveals recurrent deletion of JAK-STAT signaling inhibitors HNRNPK and SOCS1 in mycosis fungoides
... Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL). Causative genetic alterations in MF are unknown. The low recurrence of pathogenic small-scale mutations (ie, nucleotide substitutions, indels) ...
12
CP690,550 inhibits oncostatin M induced JAK/STAT signaling pathway in rheumatoid synoviocytes
... Recently, JAK inhibition has been shown to have a prominent effect on autoimmune dis- eases ...available JAK antago- nist that is in development for the treatment of RA ...
10
Series Introduction: JAK STAT signaling in human disease
... downstream signaling entails tyrosine phospho- ...This signaling paradigm first appeared in invertebrates and has continued to grow in complexity through verte- brate and mammalian ...
6