JAK2-STAT3 signal pathway
Original Article Protective effect of apigenin against myocardium injury in ischemia reperfusion rats by stimulating JAK2/STAT3 signal pathway
... of JAK2 and STAT3 was further strengthened by apigenin (2, 4 mg/kg/) in a dose-dependent ...stimulating JAK2/STAT3 signal pathway, decreasing oxidative ...
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The role of the JAK2-STAT3 pathway in pro-inflammatory responses of EMF-stimulated N9 microglial cells
... regarding signal transduction mechanisms and molecular targets of EMF-activated ...JAK-STAT pathway in EMF-activated ...JAK-STAT pathway have been detected in glial cells in the brain ...
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Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells
... Currently, existing studies on anlotinib mostly focused on the antiangiogenic role and induction of tumor cell apoptosis [5, 7, 25], and data demonstrated that the effects of anlotinib on autophagy are still rare. In ...
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Induction of metastatic potential by TrkB via activation of IL6/ JAK2/STAT3 and PI3K/AKT signaling in breast cancer
... JAK/STAT signal pathway-mediated tumor metastasis and EMT ...of JAK2/STAT3 by inducing c-Src- JAK2 complex ...to JAK2 and inhibits SOCS3-mediated JAK2 degradation, ...
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Bacterial Lipopolysaccharide Vigorously Activate JAK2/STAT3 Induced Rheumatoid Arthritis Collate with Complete Freund's Adjuvant in Experimental Rats
... on JAK2/STAT3-induced RA, compared to the traditional Complete Freund’s Adjuvant (CFA)-induced ...phosphorylated JAK2 and STAT3, while serum samples used for biochemical evaluation of ...
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Original Article IL-9 promotes proliferation and metastasis of hepatocellular cancer cells by activating JAK2/STAT3 pathway
... kinases/ signal transducer and activator of transcription 3 (JAK/STAT3) pathway is involved in the patho- genesis of different types of solid tumor [4, ...JAKs, STAT3 translocate to nucleus ...
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Original Article Anticancer effect of salidroside on colon cancer through inhibiting JAK2/STAT3 signaling pathway
... of STAT3 signal related ...in JAK2/STAT3 signaling, while MMP- 2 and MMP-9 proteins levels were decreased and protein expression of VEGF and VEGFR-2 were ...in JAK2/ ...
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Original Article Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in bladder cancer
... that signal through JAK-STAT pathway or through receptor protein tyrosine kinase (RPTK) ...on JAK2 and blocks substrate association ...attenuate signal responses to cytokines and growth ...
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Scutellarin protects human retinal pigment epithelial cells against hydrogen peroxide (H2O2)-induced oxidative damage
... of JAK2/STAT3 signaling ...the JAK2/STAT3 signaling pathway ...a STAT3 signal pathway ...enhancing JAK2/STAT3 pro-survival signaling ...the ...
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S promotes cancer progression by activating JAK2/STAT3 signaling pathway in esophageal EC109 cells
... JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2), are selec- tively associated with the cytoplasmic domains of various cytokine receptors ...the JAK2 pathway may result in a substantial increase in ...
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Original Article Panax notoginseng saponins protects H9c2 cardiomyocytes against hypoxia/reoxygenation injury via activating the JAK2/STAT3 pathway
... (JAK/STAT) pathway is a stress- responsive mechanism that has been implicat- ed in variety of cardiac pathophysiologic pro- cesses including hypertrophy, apoptosis, oxida- tive stress, myocardial interstitial ...
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Circ_ZNF124 promotes non-small cell lung cancer progression by abolishing miR-337-3p mediated downregulation of JAK2/STAT3 signaling pathway
... despite STAT3 (signal transducer and activator of transcription 3), JAK2 was also a target of miR-337-3p, overexpression of miR-337-3p greatly downregulated JAK2, STAT3 and ...
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Original Article The JAK2/STAT3 pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats
... and signal transducer and activator 3 of transcription (JAK2/STAT3) signaling pathway participates in the neuroprotective effects of ...of JAK2/ STAT3 signaling ...
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A novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carcinoma
... GPC3 pathway by which the proliferation of HCC cells is ...SMC4. JAK2/Stat3 was identified as the tar- get of SMC4. JAK2, a member of the Janus (JAK) family of non-receptor protein tyrosine ...
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Original Article Circulating levels of molecules associated with JAK2/STAT3 signaling pathway in patients with acute pancreatitis
... receptor signal- ing pathway. The JAK2/STAT3 signaling pathway is induced by their proteins phosphoryla- ...that JAK2/STAT3 signaling path- way is activated in AP ...the ...
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STAT3 and STAT5 Activation in Solid Cancers
... of STAT3 in astrocytes increased their ...of STAT3 and PTEN in the prostate confirmed the tumor suppressor functions of STAT3 and found that STAT3 induces the expression of p19ARF [82] ...of ...
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An inhibitor of cholesterol absorption displays anti-myeloma activity by targeting the JAK2-STAT3 signaling pathway
... the STAT3 signaling ...decreased STAT3 phosphorylation at Tyr705, an activated form of STAT3, in all cell lines ...inhibit STAT3 activation in a short-time period, RPMI- 8226 cells were ...
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Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway in murine models of stroke
... Pretreatment with SN attenuates OGD-induced toxicity through a specific signaling pathway in PCCs. (A–C) Representative microscopic mor- phology of PCCs under various conditions (control, SN plus OGD, and OGD ...
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The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance
... intrinsic JAK2 expression was elevated by RT, consequently leading to STAT3 activation and collectively limiting RT-induced apoptosis and enhancing the clono- genic potential of cells surviving RT ...that ...
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Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2–STAT3 pathway
... antibodies JAK2 (1:1,000, AB_2128522; Cell Signaling Technology, Danvers, MA, USA), phospho-JAK2 (phospho-Y1007 + Y1008, 1:1,000, AB_775808; Abcam, Cambridge, UK), STAT3 (1:1,000, AB_331269; Cell ...
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