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Janus kinase 2

Comprehensive kinase profile of pacritinib, a nonmyelosuppressive Janus kinase 2 inhibitor

Comprehensive kinase profile of pacritinib, a nonmyelosuppressive Janus kinase 2 inhibitor

... of Janus kinase 2 (JAK2), JAK2V617F, and fms-like receptor tyrosine kinase 3, is in Phase III development in ...receptor-associated kinase 1 achieved half-maximal inhibitory ...

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Integrated in Silico Docking and MoMA Simulation
Methods Reveal Rottlerin as a Potent Janus kinase 2
(JAK2) Inhibitor

Integrated in Silico Docking and MoMA Simulation Methods Reveal Rottlerin as a Potent Janus kinase 2 (JAK2) Inhibitor

... Janus kinase 2 (JAK2) is a prospective drug target for myeloproliferative neoplasms, mainly polycythemia Vera, essential thrombocythemia and primary myelofibrosis ...tyrosine kinase inhibitors ...

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Splenomegaly in myelofibrosis—new options for therapy and the therapeutic potential of Janus kinase 2 inhibitors

Splenomegaly in myelofibrosis—new options for therapy and the therapeutic potential of Janus kinase 2 inhibitors

... activating Janus kinase 2 (JAK2) activating mutation (JAK2V617F) that is present in almost all patients with PV and in about 50-60 % of patients with ET and PMF led to the initiation of several ...

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Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis

Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis

... agents. Janus kinase 2 (JAK2), one of the key molecules in inflammation, transduces signals downstream of various inflammatory cytokines, and some Janus kinase inhibitors have already ...

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Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor negative breast cancer via Src family kinase mediated, janus kinase 2 independent pathway

Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor negative breast cancer via Src family kinase mediated, janus kinase 2 independent pathway

... JAK2: janus kinase 2; LEPR: leptin receptor; LEPR-Long: longest isoform of LEPR; LN: lymph node; MRPL19: mitochondrial ribosomal protein L19; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl ...

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Combination of the ABL kinase inhibitor imatinib with the Janus kinase 2 inhibitor TG101348 for targeting residual BCR-ABL-positive cells

Combination of the ABL kinase inhibitor imatinib with the Janus kinase 2 inhibitor TG101348 for targeting residual BCR-ABL-positive cells

... phere. The JAK2 inhibitor TG101348 was purchased from Shanghai APIs Chemical (Shanghai, China) and the ABL kinase inhibitor imatinib was provided by Novartis Pharma AG (Basel, Switzerland). Stock solutions of ...

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A highly selective, orally active inhibitor of Janus kinase 2, CEP 33779, ablates disease in two mouse models of rheumatoid arthritis

A highly selective, orally active inhibitor of Janus kinase 2, CEP 33779, ablates disease in two mouse models of rheumatoid arthritis

... Acclimated mice were randomized, prebled and mea- sured for baseline inflammation before any studies were initiated. On day 0, DBA/1 female mice were given a primary immunization with equal volumes of bovine CII, ...

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... FIGURE 3. PV/ET/PMF/MPN-U patients are categorized according to detected driver gene mutation (JAK2, CALR, and MPL). Presence of driver mutation in JAK2 gene had an impact on higher RBC and Hb values (*) compared to ...

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Biologically inactive growth hormone caused by an amino acid substitution

Biologically inactive growth hormone caused by an amino acid substitution

... GHR, janus kinase 2 (JAK2), and signal transducers and activators of transcription 5 (STAT5) in IM-9 cells was detected by Western blotting as described previously, with modifications (9, 15, ...

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A case of minor BCR-ABL1 positive acute lymphoblastic leukemia following essential thrombocythemia and originating from a clone distinct from that harboring the JAK2-V617F mutation

A case of minor BCR-ABL1 positive acute lymphoblastic leukemia following essential thrombocythemia and originating from a clone distinct from that harboring the JAK2-V617F mutation

... of Janus Kinase 2 (JAK2) revealed that the V617F mutation was present in granulocytes and in hematopoietic stem and progenitor cells (HSPCs), but not in the CD34 + CD19 + population that mostly ...

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Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms

Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms

... JAK2: janus kinase 2; STAT5: signal transducer and activator of transcription 5; STAT3: signal transducer and activator of transcription 3; MAPK: mitogen-activated protein kinases; ERK: extracellular ...

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Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis

Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis

... swelling; 2 = two joints affected or mild diffuse erythema and swelling; 3 = three joints affected or mild diffuse erythema and swelling; 4 = four joint affected or marked dif- fuse erythema and swelling; and 5 = ...

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Interleukin 27 polymorphisms in HCV RNA positive patients: is there an impact on response to interferon therapy?

Interleukin 27 polymorphisms in HCV RNA positive patients: is there an impact on response to interferon therapy?

... subunits, Epstein-Barr virus-induced gene 3 (EBI3) and IL-27p28, which engages a receptor composed of gp130 and IL-27Ra activating Janus kinase (JAK)/signal transdu- cer and activator of transcription ...

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TRAF1 Is a Critical Regulator of JNK Signaling by the TRAF-Binding Domain of the Epstein-Barr Virus-Encoded Latent Infection Membrane Protein 1 but Not CD40

TRAF1 Is a Critical Regulator of JNK Signaling by the TRAF-Binding Domain of the Epstein-Barr Virus-Encoded Latent Infection Membrane Protein 1 but Not CD40

... The ability of both CD40 and LMP1 CTAR2 to activate JNK in cell lines lacking detectable TRAF1 indicates that TRAF1 is not critical for these activities. Furthermore, we have demon- strated that exogenous expression of ...

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Unleashing The Potential Of Multiple-Targeted Therapies In Hepatobiliary Cancers: Two Cases, Cocktail Therapy With Nine Molecular Targeted Agents And Long-Lasting Survival

<p>Unleashing The Potential Of Multiple-Targeted Therapies In Hepatobiliary Cancers: Two Cases, Cocktail Therapy With Nine Molecular Targeted Agents And Long-Lasting Survival</p>

... JAK, janus kinases; MTDs, molecular targeted drugs; RTK, receptor tyrosine kinase; TACE, transcatheter arterial chemoembolization; TM, tumor markers; SD, stable disease; VEGFR, vascular endothelial growth ...

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Targeting IFN/STAT1 Pathway as a Promising Strategy to Overcome Radioresistance

<p>Targeting IFN/STAT1 Pathway as a Promising Strategy to Overcome Radioresistance</p>

... dehydrogenase 2; ALDOA, fructose-bisphosphate aldolase A; ATP5A1, ATP synthase, H+ transporting, mitochondrial F1complex, alpha subunit 1, cardiac muscle; ATP5PO, ATP Synthase Peripheral Stalk Subunit OSCP; ATP5B, ...

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Incorporating Radiation Oncology into Immunotherapy: proceedings from the ASTRO-SITC-NCI immunotherapy workshop

Incorporating Radiation Oncology into Immunotherapy: proceedings from the ASTRO-SITC-NCI immunotherapy workshop

... Interestingly, Janus kinase (JAK) inhibitors suppressing tumor IFN signaling might represent a pharmacologic strategy that may help over- come this multigenic resistance program ...

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A Robust Fabrication Method for Amphiphilic Janus Particles via Immobilization on Polycarbonate Microspheres Karthik Ananth Mani 1, Noga Yaakov1 , Yafit Itzhaik Alkotzer 1, Evgeni Zelikman2 , and Guy Mechrez 1,

A Robust Fabrication Method for Amphiphilic Janus Particles via Immobilization on Polycarbonate Microspheres Karthik Ananth Mani 1, Noga Yaakov1 , Yafit Itzhaik Alkotzer 1, Evgeni Zelikman2 , and Guy Mechrez 1,

... amphiphilic Janus particles based on immobilization of polymethylsilsesquioxane (PMSQ) particles on polycarbonate (PC), a high impact-resistance polymer with superior mechanical ...

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A role for type 111 interferons in the natural killer cell immune response to virus

A role for type 111 interferons in the natural killer cell immune response to virus

... IFN stimulated gene IFN stimulated gene factor IFN stimulated response elements Immunoreceptor tyrosine-based inhibitory motif Janus kinase Killer immunoglobulin -like receptor Lymphokin[r] ...

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A screen for peptide agonists of the G CSF receptor

A screen for peptide agonists of the G CSF receptor

... of 2 amino ...Figure 2 with means of the two positive controls over all screened plates indicated as red lines in the diagram (dotted, lower positive control; dashed, upper positive con- ...

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