JC polyomavirus
5-HT2 Receptors Facilitate JC Polyomavirus Entry
... C polyomavirus (JCPyV) is the etiological agent of progressive multifocal leukoencephalopathy (PML), a fatal, neurodegen- erative ...(4–11). JC polyomavirus has also been detected in B lymphocytes, ...
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JC Polyomavirus Uses Extracellular Vesicles To Infect Target Cells
... ABSTRACT The endemic human JC polyomavirus (JCPyV) causes progressive multi- focal leukoencephalopathy in immune-suppressed patients. The mechanisms of virus infection in vivo are not understood because the ...
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A loop mediated isothermal amplification assay for the detection and quantification of JC polyomavirus in cerebrospinal fluid: a diagnostic and clinical management tool and technique for progressive multifocal leukoencephalopathy
... JCV: JC polyomavirus; JEV: Japanese encephalitis virus; LAMP: Loop-mediated isothermal amplification; LCMV: Lymphocytic choriomeningitis virus; LP: Loop-primer; MeV: Measles virus; MPyV: Murine ...
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Multiplex Real Time PCR Assay for Simultaneous Quantification of BK Polyomavirus, JC Polyomavirus, and Adenovirus DNA
... In recent years, virus-induced nephropathy caused mainly by BK polyomavirus (BKPyV), JC polyomavirus (JCPyV), and adenovirus has emerged as a problem in renal transplant patients. In the present ...
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Viral miRNAs in plasma and urine divulge JC polyomavirus infection
... human JC polyomavirus (JCPyV) is the etiological agent of Progressive Multifocal Leukoencephalopathy (PML), a demyelinating disease of the brain caused by lytic infection of oligodendrocytes upon viral ...
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ERK Is a Critical Regulator of JC Polyomavirus Infection
... human JC polyomavirus (JCPyV), a virus that resides in the kidney of the majority of the population and can cause the fatal, demyelinating disease progressive multifocal leukoencephalopathy (PML) in the ...
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Detection of JC Polyomavirus tumor antigen in gastric carcinoma: a report from Iran
... Before real-time PCR, 400 ng of DNA was treated with 0.26 unit of topoisomerase I (BioLabs M0301S) for 45 minutes at 37°C to enhance primer access to supercoiled JC genomic DNA. For detection of JCV T-Ag ...
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JC Polyomavirus Entry by Clathrin-Mediated Endocytosis Is Driven by β-Arrestin
... J C polyomavirus (JCPyV) is the etiological agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML) (1, 2). Although PML is rare, ⬃ 40% to 75% of the human population is thought ...
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Progressive Multifocal Leukoencephalopathy Associated Mutations in the JC Polyomavirus Capsid Disrupt Lactoseries Tetrasaccharide c Binding
... JCPyV pseudovirus production. Codon optimization of the JCPyV VP1, VP2, and VP3 genes was performed according to the National Can- cer Institute Center for Cancer Research Lab of Cellular Oncology Tech- nical Files ...
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JC Polyomavirus Infection of Primary Human Renal Epithelial Cells Is Controlled by a Type I IFN Induced Response
... The JC and BK human polyomaviruses (JCPyV and BKPyV, respectively) establish lifelong persistent infections in the ...causes polyomavirus-associated nephropathy ...
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Novel Polyomavirus Detected in the Feces of a Chimpanzee by Nested Broad-Spectrum PCR
... BK polyomavirus (BKPyV), JC polyomavirus (JCPyV), LPyV, murine polyomavirus (MPyV), mouse pneumotropic polyomavirus (MPtV), hamster polyomavirus (HaPyV), goose hemorrhagic ...
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Age-Specific Seroprevalence of Merkel Cell Polyomavirus, BK Virus, and JC Virus
... cell polyomavirus (MCPyV) in a baculovirus expression system and devel- oped a virus-like particle (VLP) enzyme-linked immunosorbent assay ...BK polyomavirus (BKPyV) ...and JC polyomavirus ...
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Malawi Polyomavirus Is a Prevalent Human Virus That Interacts with Known Tumor Suppressors
... ing JC polyomavirus (JCPyV) and BK polyomavirus (BKPyV), can cause significant disease, primarily in immunocompromised in- dividuals, with increased virus levels contributing to the progres- sion of ...
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Multiplex detection in tonsillar tissue of all known human polyomaviruses
... Abbreviations BBMA: Bead-based multiplex assay; BKPyV: BK polyomavirus; HPyVs: Human polyomaviruses; JCPyV: JC polyomavirus; MCC: Merkel cell carcinoma; MCPyV: Merkel cell polyomavirus; [r] ...
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Analysis of Capsid Formation of Human Polyomavirus JC (Tokyo-1 Strain) by a Eukaryotic Expression System: Splicing of Late RNAs, Translation and Nuclear Transport of Major Capsid Protein VP1, and Capsid Assembly
... Human polyomavirus JC (JCV) can encode the three capsid proteins VP1, VP2, and VP3, downstream of the agnoprotein in the late region. JCV virions are identified in the nucleus of infected cells. In this ...
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Infection by agnoprotein negative mutants of polyomavirus JC and SV40 results in the release of virions that are mostly deficient in DNA content
... Background: Human polyomavirus JC (JCV) is the etiologic agent of a brain disease, known as progressive multifocal leukoencephalopathy (PML). The JCV genome encodes a small multifunctional phospho-protein, ...
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Comparison of real time PCR and hemagglutination assay for quantitation of human polyomavirus JC
... Human polyomavirus JC (JCV), the etiological agent of the disease progressive multifocal leukoencephalopathy (PML) affects immunocompromised patients particularly patients with ...
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Typing of human polyomavirus JC virus on the basis of restriction fragment length polymorphisms
... We found that 10 of the 15 urine-derived isolates obtained from three geographical regions other than Japan carried the archetypal regulatory sequence, with a few nucleotide mismatches F[r] ...
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Molecular Cloning and Expression of Major Structural Protein VP1 of the Human Polyomavirus JC Virus: Formation of Virus-Like Particles Useful for Immunological and Therapeutic Studies
... human polyomavirus JC virus (JCV) is the etiological agent of progressive multifocal leukoencephalopathy (PML), the only known viral demyelinating disease of humans ...
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Cloned human polyomavirus JC DNA can transform human amnion cells.
... EcoRI cleav- Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The genome of the human polyomavirus JC Mad-i strain was molecularly cloned in Escherichia coli by using th[r] ...
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