Joint damage
Effects of baricitinib on radiographic progression of structural joint damage at 1 year in patients with rheumatoid arthritis and an inadequate response to conventional synthetic disease modifying antirheumatic drugs
... Methods in ra-BUilD, patients were randomised to placebo, baricitinib 2 mg or 4 mg once daily, with rescue possible from week 16. Patients completing ra-BUilD and entering ra-BeYOnD continued to receive the baricitinib ...
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14 3 3η is a novel mediator associated with the pathogenesis of rheumatoid arthritis and joint damage
... As with proof-of-concept studies, one of the main li- mitations of the present study is the small sample size for both RA cohorts. In addition, relatively few patients demonstrated substantial joint damage ...
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Rheumatoid arthritis treatment: the earlier the better to prevent joint damage
... approach. 12 13 The TICORA study analysed the differ- ences between a sustained, tight control, DAS-driven approach to RA compared with clinical routine out- patient care, reporting an EULAR good response in 82% of ...
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Joint damage in rheumatoid arthritis: assessment of a new scoring method
... of joint space widths using the Z-Score based on CAJSA esti- mates in patients with RA, in particular the MCP JSD of the second and third fingers as a surrogate marker of RA ...develop joint damage ...
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A profile of immune response to herpesvirus is associated with radiographic joint damage in rheumatoid arthritis
... for joint structure and function in patients with ...retard joint destruction in the ...of joint damage ...for joint damage ...
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Studies on ageing and the severity of radiographic joint damage in rheumatoid arthritis
... radiographic joint damage and that this effect is inde- pendent of the effects of CRP and SJC on radiographic progression [22, ...of joint damage, independent of other measures of inflam- ...
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Variation at interleukin 6 receptor gene is associated to joint damage in rheumatoid arthritis
... capture joint damage, we first used a sample of RA pa- tients to compare its correlation with a reference ...of joint damage was measured using the S-score and the Sharp–van der Heijde Score ...
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Early biomarkers of joint damage in rheumatoid and psoriatic arthritis
... predict joint damage at an early stage would support more informed clinical decisions on the most appropriate treatment regimens for individual ...(joint) damage, and outlined how mass ...
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Sensory response following knee joint damage in rabbits
... Joint damage often leads to arthrogenic muscle inhib- ition in the quadriceps musculature ...damaged joint structures resulting in a failure to voluntarily activate motor ...or joint effusion ...
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A genetic study on C5 TRAF1 and progression of joint damage in rheumatoid arthritis
... of joint destruction per year compared to patients with the com- mon genotype; this equals a 36% ...of joint destruction over seven years (Figure ...
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Smoking in combination with antibodies to cyclic citrullinated peptides is associated with persistently high levels of survivin in early rheumatoid arthritis: a prospective cohort study
... and repeatable finding. The cellular origin and processes, which lead to extracellular accumulation of survivin in the blood and synovial fluid of RA patients remains elu- sive. The cells of nontumoural origin, ...
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Profile of tocilizumab and its potential in the treatment of giant cell arteritis
... Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized p[r] ...
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... fi rmed that radiograms of seronegative patients diff er signifi - cantly from radiograms of seropositive patients concerning the lower rate of juxta-articular osteoporosis, relative lack of subchondral erosion, ...
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Serial determination of cyclic citrullinated peptide autoantibodies predicted five year radiological outcomes in a prospective cohort of patients with early rheumatoid arthritis
... structural joint damage in patients with early rheumatoid arthritis (RA), compared to a single baseline ...radiographic damage at baseline (odds ratio (OR), ...
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Predictive factors for the development and disease course of rheumatoid arthritis
... the joint and, more specifically, in fibroblast-like ...of joint damage and were further supported by the results of a multivari- ate analysis showing that when both the genetic variant and serum ...
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Association of the different types of radiographic damage with physical function in patients with rheumatoid arthritis: analysis of the RAPID trials
... tissue damage (SLUX) from cartilage loss ( ‘ real ’ ...radiographic joint damage on several aspects of functional outcome (HAQ-score, grip strength, dexterity-score) in patients with ...
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Histological Changes of Cartilage Degeneration in Osteoarthritic Rabbits
... 14. Roman-Blas, J. A., Mediero, A., Tardío, L., Portal-Nuñez, S., Gratal, P., Herrero-Beaumont,. G., Largo, R., The combined therapy with chondroitin sulfate plus glucosamine sulfate or chondroitin sulfate plus ...
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The commercial pig as a model of spontaneously occurring osteoarthritis
... In addition to the spontaneous development of OA joint damage, the commercial pig represents an excellent tissue source for in vitro and ex-vivo OA models. Indeed, cultured osteoblasts retained a “ damaged ...
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Unravelling the anti-carbamylated protein antibody response in rheumatoid arthritis
... connective tissues, muscles and the joints. In addition to similarities, there is also significant variety across the RMD spectrum including inflammatory and non- inflammatory diseases. Rheumatoid arthritis (RA) and ...
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The need for prognosticators in rheumatoid arthritis Biological and clinical markers: where are we now?
... predicting joint damage ...of joint damage: ...of joint destruction is much higher in patients positive for rheumatoid factor when compared with seronegative patients ...
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