Jun N-terminal kinase
Jun N terminal kinase maintains tissue integrity during cell rearrangement in the gut
... vertebrates, Jun N-terminal kinase (JNK) is also required for tissue elongation, but the precise cellular role of JNK in this context has remained ...Rho kinase is necessary to induce ...
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Anti-high mobility group box-1 (HMGB1) antibody attenuates kidney damage following experimental crush injury and the possible role of the tumor necrosis factor-α and c-Jun N-terminal kinase pathway
... Previous studies have demonstrated that HMGB1 could increase the production of TNF-α indirectly [13] and also increase the level of c-Jun N-terminal kinase (JNK), known as stress-activated ...
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The Influenza A Virus NS1 Protein Inhibits Activation of Jun N-Terminal Kinase and AP-1 Transcription Factors
... of Jun N- terminal kinase (JNK) (also termed stress-activated protein kinase [SAPK]), which in turn phosphorylates and thereby upregulates the activity of transcription factors of the ...
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c Jun N terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
... protein kinase (MAPK) cascades are involved in inflammation and tissue destruc- tion in rheumatoid arthritis ...c-Jun N-terminal kinase (JNK) is highly activated in RA fibroblast-like ...
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Human Endotoxemia Activates p38 MAP Kinase and p42/44 MAP Kinase, But Not c-Jun N-terminal Kinase
... Protein Kinase (MAPK) family are critically involved in intracellular signal trans- duction, mediating cell responses to a variety of dif- ferent infectious and inflammatory ...c-jun ...
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c Jun N terminal kinase activity supports multiple phases of 3D mammary epithelial acinus formation
... c-Jun N-terminal kinase (JNK) activity for acinus ...regulated kinase (ERK) phosphorylation, cell proliferation, adhesion-independent cell survival and expression of ...
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Role of Jun N terminal Kinase (JNK) signaling in the wound healing and regeneration of a Drosophila melanogaster wing imaginal disc
... ABSTRACT When a fragment of a Drosophila imaginal disc is cultured in growth permissive conditions, it either regenerates the missing structures or duplicates the pattern present in the fragment. This kind of pattern ...
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c Jun N terminal kinase activation by nitrobenzoxadiazoles leads to late stage autophagy inhibition
... c-Jun N-terminal kinase (JNK) [2, 3, 13, ...signal-regulating kinase (ASK1), which in turn activates both p38 and JNK mito- gen-activated protein kinase (MAPK) signaling pathways ...
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Original Article The C-jun N-terminal kinase signaling pathway regulates cyclin D1 and cell cycle progression in airway smooth muscle cell proliferation
... signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K) pathways in ASMC proliferation are well established, the mechanisms by which the c-jun N-terminal kinase (JNK), ...
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Inhibition of c Jun N terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
... ABSTRACT: Oocyte ageing is a complex of processes that occur when matured in vitro oocytes are, after rea- ching the metaphase II stage, exposed to further in vitro culture. Aged oocytes remaining at the metaphase II ...
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Dual Role of Jun N-Terminal Kinase Activity in Bone Morphogenetic Protein-Mediated Drosophila Ventral Head Development
... c-Jun N-terminal kinase pathway but in opposite ...both Jun N-terminal kinase and Dpp activity in peripodial cells causes stronger vibrissae, rostral membrane, and ...
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Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
... protein kinase kinase 4 (MKK4), which, in turn, phosphorylates ...cause terminal swelling [32] and sprout- ing [33] at the NMJ that is similar to what we observed in the TgUsp14CA mice (Figure 3H), ...
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C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
... One of the hallmark neuropathological features of TDP- 43 proteinopathies is the formation of C-terminal TDP- 43 fragments (CTF-TDP-43), often of 35 or 25 kDa in mass [6,8]. Cell studies have re-capitulated ...
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Varicella-Zoster Virus Infection of Human Fibroblast Cells Activates the c-Jun N-Terminal Kinase Pathway
... Activated JNK localizes to the nucleus in VZV-infected cells. The location of phosphorylated JNK within the cell determines its access to substrates and potential interacting proteins, both viral and cellular. ...
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Activation of c-jun N-terminal kinase in spinal cord contributes to breast cancer induced bone pain in rats
... such as TNF-α, IL-1β and IL-6. It has been well accepted that after nerve injury, levels of proinflammatory cytokines increased in the spinal cord and became the primary activa- tors of the JNK pathway [4,28,29]. Several ...
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c-Jun N-terminal kinase activation has a prognostic implication and is negatively associated with FOXO1 activation in gastric cancer
... Previously, Shibata et al. [20] reported that JNK activa- tion was found in 40 % of gastric cancer cases and that there was no association between JNK activation and Lauren’s classification. However, our results showed ...
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Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c Jun N Terminal kinase pathway
... Cytokine-induced JNK activation is dependent on MKK7 in cultured FLS and does not require MKK4. To determine the effect of selective MKK7 deficiency on JNK signaling in vivo , the ankle joints were evaluated by Western ...
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MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts
... receptor-like kinase 5; AP-1: Activator protein-1; BM: Bone marrow; ChIP: Chromatin immunoprecipitation; CTGF: Connective tissue growth factor; CXCR4: CXC receptor 4; ECM: Extracellular matrix; ERK: Extracellular ...
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Flavonoids in modulation of cell survival signalling pathways
... c-Jun N-terminal kinase (JNK), and p38, MAPKs (Johnson and Lapadat ...protein kinase (SAPK), is an important member of the MAPKs super- family, the members of which are readily ...
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Original Article Puerarin modulates autophagy to ameliorate cerebral ischemia/reperfusion injury through JNK signaling pathway
... Abstract: Puerarin, a major isoflavone in radix puerariae, exerts remarkable pharmacological effects on ischemic stroke patients in the clinic. However, the underlying mechanisms of the protective effects of puerarin are ...
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