Jun N-terminal kinases
C Jun N terminal kinases/c Jun and p38 pathways cooperate in ceramide induced neuronal apoptosis
... c- Jun N-terminal kinases (JNK) and p38 are important reg- ulators of the cell death program in post-mitotic neurons following survival-factor withdrawal (Mielke and Herdegen, ...
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The Jun N-terminal kinases signaling pathway plays a “seesaw” role in ovarian carcinoma: a molecular aspect
... However, some evidence also shows contradictory phenomena that lacking the JNK1/2 gene induces fetal death in mice. JNKs also control cell autophagy, prolifer- ation or migration. Furthermore, experiments involving the ...
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Epstein-Barr Virus Immediate-Early Proteins BZLF1 and BRLF1 Activate the ATF2 Transcription Factor by Increasing the Levels of Phosphorylated p38 and c-Jun N-Terminal Kinases
... ation, osmotic shock, inflammatory cytokines, and growth fac- tors, among others) induce activation of the cellular stress MAP kinases (7, 52, 72). Induction of the stress MAP kinase cascade has a multitude of ...
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Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors
... 21. Szczepankiewicz BG, Kosogof C, Nelson LT, Liu G, Liu B, Zhao H, Serby MD, Xin Z, Liu M, Gum RJ, Haasch DL, Wang S, Clampit JE, Johnson EF, Lubben TH, Stashko MA, Olejniczak ET, Sun C, Dorwin SA, Haskins K, Abad- ...
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Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases.
... signal-regulated kinases (ERKs) and the c-Jun N-terminal kinases ...by N- terminal phosphorylation of c-Jun carried out by HBx-activated ...
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Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells
... NSCLC: Non-small cell lung cancer; SAPK/JNK: Stress-activated protein kinases/c-Jun N-terminal kinases; DNMT1: [DNA (cytosine-5- )-methyltransferase 1]; EZH2: Enhancer of zeste 2 polycom[r] ...
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Differential roles of p38 MAPK and JNKs in mediating early protection or apoptosis in the hyperthermic perfused amphibian heart
... In the present study the activation of p38 mitogen-activated protein kinase (p38-MAPK) and c-Jun N-terminal kinases (JNKs) by hyperthermia was investigated in the isolated perfused Rana ...
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C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
... stress kinases such as JNK and p38 in ALS has been suggested through recent ...these kinases as well as modulation of ERK ...other kinases activation across the disease course in ...additional ...
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The Influenza A Virus NS1 Protein Inhibits Activation of Jun N-Terminal Kinase and AP-1 Transcription Factors
... The present characterization of NS1 as a specific antagonist of virus- and dsRNA-induced activation of JNK and its down- stream targets is, to our knowledge, the first report of such a property of a viral protein. We ...
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Human Endotoxemia Activates p38 MAP Kinase and p42/44 MAP Kinase, But Not c-Jun N-terminal Kinase
... In contrast to p38 MAPK and p42/44 MAPK, JNK activation could not be detected during human endo- toxemia, while in vitro these kinases are often simul- taneously stimulated by LPS and other stimuli (12,20, 21). ...
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DISCOVERY OF NOVEL AND SELECTIVE C JUN NH2 TERMINAL KINASES 2 INHIBITORS BY TWO DIMENSIONAL QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP MODEL DEVELOPMENT, MOLECULAR DOCKING AND ABSORPTION, DISTRIBUTION, METABOLISM, ELIMINATION PREDICTION STUDIES: AN IN SILICO APPROACH
... were imported in the TSAR worksheet, after their conversion into. molfile format. After which, three substituents (R1, R2, and R3) in each molecule, using ‘‘define substituent’’ option in TSAR, were defined around ...
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c Jun N terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
... c-Jun N- terminal kinase (JNK), extracellular regulating kinase (ERK), and p38 kinase ...MAPK kinases (MAPKKs), which themselves are activated by MAPKK kinases ...
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Varicella-Zoster Virus Infection of Human Fibroblast Cells Activates the c-Jun N-Terminal Kinase Pathway
... the cytoplasm and nuclei of quiescent cells; stimulation by UV irradiation is known to cause accumulation of phospho-JNK-1 in the nucleus (6). Finding phospho-JNK in discrete nuclear foci (speckles) within VZV-infected ...
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c Jun N terminal kinase activity supports multiple phases of 3D mammary epithelial acinus formation
... (CSF-1R) had been induced. This resulted in a severe disruption of MCF10A acinus architecture where excessive proliferation and aberrant survival was accompanied by progressive disruption of cell–cell adhesion in these ...
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Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis like systemic inflammatory response in mice
... protein kinases (MAPKs) [extracellular related kinase (ERK) and c-jun-NH2 terminal kinase (JNK)], the production of cytokines [tumor necrosis alpha (TNFa), interleukin-1b (IL-1b), interleukin-6 ...
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Regulation of cardiac hypertrophy in vivo by the stress activated protein kinases/c Jun NH2 terminal kinases
... Inhibition of pressure overload–induced cardiac hypertrophy by gene transfer of SEK-1(KR): postmortem measurements. (a and b) Ratio of LV weight to body weight and quantitation of wall thickness. Animals (n = 7 in ...
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An investigation of the regulation and role of c-Jun during neuronal apoptosis
... 1994). In addition, JunB and JunD are not able to heterodimerise with ATF-2 (Benbrook and Jones, 1990; Hai and Curran, 1991). Another possibility is that post- translational modification of pre-bound factors occurs. In ...
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Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
... cause terminal swelling [32] and sprout- ing [33] at the NMJ that is similar to what we observed in the TgUsp14CA mice (Figure 3H), we investigated whether this pathway was hyperactivated in the TgUsp14CA ...
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Acute hypertension activates mitogen activated protein kinases in arterial wall
... MAP kinases has come from studies on cultured ...MAP kinases in rat ...c- jun , and junD gene expres- sion and enhanced DNA-binding activity of AP-1 transcrip- tion factor ...
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JIP1 Regulates Axonal Transport of APP and Autophagosomes via Coordination of Kinesin and Dynein Motors
... Neurons are specialized cells that extend polarized processes called dendrites and axons in order to maintain synaptic connections over long distances. Consequently, neuronal homeostasis requires axonal transport of ...
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