Jun NH2-terminal kinase
Inhibition of c-Jun NH2-terminal kinase or extracellular signal-regulated kinase improves lung injury
... MAP Kinase inhibitors has been proposed as a selec- tive intervention to reduce LPS-induced lung inflamma- tion due to decreases in neutrophil recruitment to the air spaces ...nal kinase (JNK) and ...
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Selective activation of the mitogen activated protein kinase subgroups c Jun NH2 terminal kinase and p38 by IL 1 and TNF in human articular chondrocytes
... points between 2 and 60 min. For comparative analysis, ali- quots of the same chondrocyte lysates were immunoprecipi- tated with antibody to ERK or p38 and tested for phosphory- lation of MBP or ATF-2 as substrates. JNK ...
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Extracellular signal regulated kinase and c Jun NH2 terminal kinase activation by mechanical stretch is integrin dependent and matrix specific in rat cardiac fibroblasts
... Stretching did not activate p38. This uncoupling of the two stress-activated protein kinases, JNK and p38, is not common. In vitro, most stimuli lead to activation of both pathways (56) while certain stimuli such as ...
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ABL N induced apoptosis in human breast cancer cells is partially mediated by c Jun NH2 terminal kinase activation
... had kinase activity in the absence of any activating upstream kinase, which showed autophosphorylation activity resulting in constitutive activation ...vitro kinase activity assay, indicating ABL-N ...
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c Jun NH2 terminal kinase activation is essential for up regulation of LC3 during ceramide induced autophagy in human nasopharyngeal carcinoma cells
... It was reported that p53 was involved in LC3 expression during prolonged starvation[44], FOXO3 upregulated LC3 expression and induced autophagy in skeletal muscle in vivo [43]. But how anticancer agents regulate LC3 ...
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Uni-axial stretch induces actin stress fiber reorganization and activates c-Jun NH2 terminal kinase via RhoA and Rho kinase in human bladder smooth muscle cells
... RhoA is a member of the Rho family of 20 to 30 kDa GTPase proteins that cycle between an active GTP- bound form and an inactive GDP-bound form. One of the important roles of RhoA is to act as a regulator of actin stress ...
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Transforming Growth Factor-β1 Downregulates Vascular Endothelial Growth Factor-D Expression in Human Lung Fibroblasts via the Jun NH2-Terminal Kinase Signaling Pathway
... Vascular endothelial growth factor (VEGF)-D, a member of the VEGF family, induces both angiogenesis and lymphangiogene- sis by activating VEGF receptor-2 (VEGFR-2) and VEGFR-3 on the surface of endothelial cells. ...
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Activated Protein C Inhibits Proliferation and Tumor Necrosis Factor α-Stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts
... Synovial fibroblast proliferation is a hallmark of the invasive pannus in the rheumatoid joint. Activated protein C (APC) is a natural anticoagulant that exerts antiinflammatory and cyto-protective effects in various ...
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C Jun NH2 Terminal Kinase Contributes to Dexmedetomidine Induced Contraction in Isolated Rat Aortic Smooth Muscle
... dexmedetomidine-induced maximal contractions in a con- centration-dependent manner, these results suggest that dex- medetomidine-induced contraction is primarily mediated by activation of a JNK-mediated pathway and, in ...
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The activation of c-Jun NH2-terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cells
... Our results suggest that autophagy was induced by DHA in the studied human pancreatic cancer cell lines. DHA also activated JNK, thus up-regulating Beclin 1. JNK activation primarily depends on ROS, which is gen- erated ...
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Poliovirus Induces Bax-Dependent Cell Death Mediated by c-Jun NH2-Terminal Kinase
... Poliovirus (PV) is the causal agent of paralytic poliomyelitis, a disease that involves the destruction of motor neurons associated with PV replication. In PV-infected mice, motor neurons die through an apoptotic ...
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Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis like systemic inflammatory response in mice
... related kinase (ERK) and c-jun-NH2 terminal kinase (JNK)], the production of cytokines [tumor necrosis alpha (TNFa), interleukin-1b (IL-1b), interleukin-6 (IL-6), macrophage inhibitory ...
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Checkpoint inhibitors in hematological malignancies
... Janus kinase/ signal transducer and activator of transcription; JNK: c-Jun NH2-terminal kinase; KO: Knock-out; LAG-3: Lymphocyte activation gene 3; LMP1: EBV latent membrane protein 1; ...
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Modulation of c Jun NH2 Terminal (JNK) by Cholinergic Autoantibodies from Patients with Sjögren’s Syndrome
... ABSTRACT Background: We wanted to determine via an immunopharmacological approach whether the c-Jun NH2 terminal kinase JNK cascade is phosphorylated in the submandibular gland by carbac[r] ...
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Functional interactions of the adenovirus serotype 5E4orf3 protein
... ISRE: IFN-stimulated response element JNK: Jun NH2 -terminal kinase Kr: Kremer bod :'s LANDS: Lymphocyte associated nuclear domains LBamp: LB covaining lOOmicrogram/ml ampicillin MARs: M[r] ...
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Regulation of cardiac hypertrophy in vivo by the stress activated protein kinases/c Jun NH2 terminal kinases
... protein kinase Cβ (5), and the serine phosphatase calcineurin and one of its targets, a nuclear factor of acti- vated T cells 3 (NF-AT3) (6) — can induce hypertrophic responses in the hearts of transgenic ...
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Crucial Role of miR-433 in Regulating Cardiac Fibrosis
... fibroblasts. Jun NH2-terminal kinases, including three isoforms (JNK1, JNK2, and JNK3), belong to the MAPK family and play major roles in development, cell proliferation, differentiation, and ...
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DISCOVERY OF NOVEL AND SELECTIVE C JUN NH2 TERMINAL KINASES 2 INHIBITORS BY TWO DIMENSIONAL QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP MODEL DEVELOPMENT, MOLECULAR DOCKING AND ABSORPTION, DISTRIBUTION, METABOLISM, ELIMINATION PREDICTION STUDIES: AN IN SILICO APPROACH
... c-Jun NH2-terminal kinases (JNKs), one of the stress-activated kinases, are the member of mitogen-activated protein kinase family. These are known to be evolutionarily conserved. Insights into ...
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Regulation of the mitogen activated protein kinase p44 ERK activity during anoxia/recovery in rainbow trout hypodermal fibroblasts
... MAP kinase kinase kinase (MAP3K) upstream of a MAPK kinase kinase (MAP2K), which in turn activates the MAP kinase (Kyriakis and Avruch, ...MAPK/ERK kinase (MEK)1/2 ...
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Jun N terminal kinase maintains tissue integrity during cell rearrangement in the gut
... vertebrates, Jun N-terminal kinase (JNK) is also required for tissue elongation, but the precise cellular role of JNK in this context has remained ...Rho kinase is necessary to induce cell ...
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