K-ATP channel
Endogenous adenosine mediates coronary vasodilation during exercise after K(ATP)+ channel blockade
... intracoronary glibenclamide in the presence of adenosine receptor blockade. Glibenclamide decreased resting coronary blood flow from 45 +/- 5 to 35 +/- 4 ml/min (P < 0.05), but did not prevent exercise-induced ...
12
Conservatively treated Congenital Hyperinsulinism (CHI) due to K-ATP channel gene mutations: reducing severity over time
... without K-ATP channel gene mutations [12, 14, 15]; however these observations do not offer insight into the evolution of disease severity and if treatment re- sponse improves or worsens over ...
11
K-ATP channel gene expression is induced by urocortin and mediates its cardioprotective effect
... potassium channel Kir ...potassium channel opening and a blocker that specifically blocks the mitochondrial potassium channel both inhibit the cardioprotective effect of ...
8
Kir6.2-containing ATP-sensitive K+ channel is required for cardioprotection of resveratrol in mice
... sarcolemmal K-ATP channels, but the exact mechanism is still unclear ...Kir6.2/K-ATP channel opening, which mediates cardioprotection of ...Kir6.2/K-ATP channel ...
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The ATP sensitive K+ channel mediates hypotension in endotoxemia and hypoxic lactic acidosis in dog
... the K+ATP channel, caused vasoconstriction and restoration of blood ...the K+ATP channel in vascular smooth muscle, and anaerobic metabolism with acidosis is a sufficient ...
5
Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: possible role in glucose sensing
... intracellular ATP/ADP levels, being essential components of a glucose ‐ sensing apparatus in various cells that couples glucose metabolism, intracellular ATP/ADP levels and membrane ...of ...
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K+ATP CHANNELS MODULATE HAEMODYNAMICS, BIOCHEMICAL AND HEMATOLOGICAL AFTER PRETREATMENT WITH THE K (ATP) OPENER PINACIDIL AND PHOSPHOLIPASE C INHIBITOR ON ETOMIDATE IN THE MICE
... instability. K + ATP channels are known to be activated by hyperpolarizing agonists, such as diazoxide, pinacidil, cromakalim, K + ATP channel agonists are used as therapeutic agents in ...
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The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes
... comparable ATP sensitivity to the channel contain- ing all wild-type subunits, so the resulting ATP sensitivity of heterozygous population is very close, but not identical, to that of a pure ...
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Nicorandil-Induced Hyperkalemia in a Uremic Patient
... In conclusion, we first reported a uremic patient who developed hyperkalemia after taking nicorandil. After detailed evaluation, we have excluded other possible etiolo- gies and nicorandil-induced potassium ...
5
Long-term medical treatment in congenital hyperinsulinism: a descriptive analysis in a large cohort of patients from different clinical centers
... total pancreatectomy, which in turn implicates the risk of either persistent hypoglycemia or insulin-requiring dia- betes [6, 7]. Therefore, long-term medical treatment was established during the last decades for diffuse ...
10
Autonomy, de facto and de jure
... Kir channel to play central roles in the channel gating (Kuo et ...the channel enters the closed state, the bulk residue blocks the ion conductance pathway and prevents the ions from passing ...the ...
211
Targeting adenosine for cancer immunotherapy
... and ATP are normally present at very low levels in extracellular fluids ...of ATP through a variety of mechanisms, including transporter- or channel-mediated release, active vesicu- lar exocytosis, ...
9
Modulation of pulmonary vasomotor tone in the fetus and neonate
... Immunohistochemical studies [13] have identified endothe- lial NOS as early as under one-third of term in lamb fetal lungs. Both expression of the endothelial NOS gene [14] and the NO-induced increase in cGMP ...
6
The effect of ATP-dependent K(+)-channel opener on the functional state and the opening of cyclosporine-sensitive pore in rat liver mitochondria
... мембраной [36] и, тем самым, ослаблять также и энергетическое сопряжение в митохондри- ях (uncoupling). следует также отметить, что ингибирование окисления либо фосфорили- рования может приводить к варьированию ...
14
The influence of ATP-dependent K(+)-channel diazoxide opener on the opening of mitochondrial permeability transition pore in rat liver mitochondria
... как K m , константа скорости транспорт- ного процесса, максимальная скорость транс- порта V max , которая в митохондриях к тому же ограничена максимальной скоростью по- требления кислорода и переноса электронов в ...
11
Increase of ATP-sensitive potassium (KATP) channels in the heart of type-1 diabetic rats
... Due to the difference between human and animal and/ or the stage of diabetes, the response of blood pressure is varied; changes of blood pressure in diabetic compli- cations seem not so simple. Numerous evidences sug- ...
9
Conversion of amylase secreting rat pancreatic AR42J cells to neuronlike cells by activin A
... cytoplasmic free calcium concentration in response to depolarizing concentration of potassium. Moreover, activin-treated AR42J cells expressed mRNA for alpha 1 subunit of the neuroendocrine/beta cell-type ...
12
KIN7 kinase regulates the vacuolar TPK1 K+ channel during stomatal closure
... (A) Pull down assays were carried out using the N-terminal part of TPK1 fused to GST as bait (or GST alone) and leaf extract from wild type plants or plants expressing KIN7::YFP as bait. A primary anti-GFP antibody and ...
35
ATP-sensitive K(+)-channels in muscle cells: features and physiological role
... від K АТР -каналів плазматичної мембрани, що широко досліджуються на мо- лекулярному рівні, та субодиниці яких клоно - вано [4, 10, 21], немає узгодженої думки сто - совно структури АТР-чутливого переносника іонів ...
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K+ CHANNEL PERMEATION AND BLOCK IN THE MIDGUT EPITHELIUM OF THE TOBACCO HORNWORM MANDUCA SEXTA
... If a channel contains several ions at a time, these ions will interact while passing in single file. One way to detect presumed mutual ionic repulsions on the macroscopic level is to analyse the current carried ...
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