K/BxN serum transfer model
Urokinase type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis models
... systemic K/BxN serum transfer model, the reduced cartilage proteoglycan loss in u-PA-/- mice is consistent with the involvement of plasmin-mediated proteolytic activity in this tissue ...
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Matrix Metalloproteinase MMP 9 Promotes K/BxN Serum Induced Arthritis in Mice
... The K/BxN serum transfer arthritis model is one such model that shares features similar to human RA ...The K/BxN mice are a cross between the KRN mice and the NOD ...
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Disease severity in K/BxN serum transfer induced arthritis is not affected by IL 33 deficiency
... Obviously, an alternative explanation for the difference in arthritis severity observed between ST2 and IL-33 KO mice might lie with the existence of another ligand for ST2, although we are not aware of data designating ...
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The caspase 8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response
... the K/BxN serum-transfer-induced model of arthritis de- pends upon the Ly6C lo monocyte population, which patrol the luminal side of the endothelium and extrava- sate into the joint ...
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CD55 deposited on synovial collagen fibers protects from immune complex mediated arthritis
... the K/BxN serum-induced experimental model of arth- ritis, we here explored the basis and the consequences of the enhanced presence of CD55 in the intimal lining ...mediated ...
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Collagenase 3 (MMP 13) deficiency protects C57BL/6 mice from antibody induced arthritis
... the K/BxN serum-induced arthritis ...the K/BxN serum in the MMP-13 –/– mice and in the control C57BL/6 ...after K/BxN serum transfer (Figure ...post ...
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Autoantibody mediated arthritis in the absence of C3 and activating Fcγ receptors: C5 is activated by the coagulation cascade
... injecting serum from K/BxN mice into normal mice ...the K/ BxN TCR transgenic mice and its derivative, the serum transfer model, likely reflecting the several-fold ...
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Reduced Locomotor Activity Correlates with Increased Severity of Arthritis in a Mouse Model of Antibody Induced Arthritis
... in K/BxN sera-injected mice, the distance traveled decreased with the progression of arthritis (Figure ...(K/BxN serum transfer—362 ± 198 cm; ...(K/BxN serum ...
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PAD4 is not essential for disease in the K/BxN murine autoantibody mediated model of arthritis
... the serum-transfer during the course of arthritis disease ...that serum IgGs from patients with Felty’s syndrome react to NETs and preferentially to citrullinated histones over unmodified histones, ...
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IL 17A deficiency promotes periosteal bone formation in a model of inflammatory arthritis
... the K/BxN serum transfer murine model of inflammatory arthritis (STA), as it has been previously demonstrated that although IL-17A is expressed at low levels, inflammation is not ...
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Matrix metalloproteinase 8 deficiency increases joint inflammation and bone erosion in the K/BxN serum transfer arthritis model
... Multiple pieces of evidence support the relevance of MMPs in the pathogenesis of RA. Several MMPs are highly expressed in the synovial lining and sublining of RA patients and high levels of these proteins have been ...
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The MHC class I–like Fc receptor promotes humorally mediated autoimmune disease
... of serum IgG Ab’s, but whether this molecule contributes to autoimmune pathogenesis remains ...the K/BxN mouse ...arthritogenic serum transfer and the more aggressive genetically ...
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ApoE deficiency exacerbates the development and sustainment of a semi chronic K/BxN serum transfer induced arthritis model
... STIA model where there is pas- sive transfer of arthritogenic anti-glucose-6-phosphate isomerase antibodies twice a ...of K/BxN serum. This is in contrast to the CIA model, which ...
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Pro apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis
... resolve K/BxN serum transfer-induced ...the K/BxN serum transfer-induced arthritis model, and fewer apoptotic cells in joints, similar to lpr and Bim-/- mice ...
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The impact of age and gut microbiota on Th17 and Tfh cells in K/BxN autoimmune arthritis
... RA, serum autoantibodies serve as the disease index in the K/BxN model and indeed, passive transfer of K/BxN arthritic serum (containing anti-GPI autoantibodies) ...
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Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation
... In addition to the collagenase and in vitro culture method of FLS isolation used in this paper, several other methods have been successfully applied for the purpose of human synovial fibroblast culture. Of particular ...
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Characterisation of fibroblast like synoviocytes from a murine model of joint inflammation
... from K/BxN mice possessed significantly greater basal expression of the inflammatory markers IL-6, chemokine ligand 2 (CCL-2) and vascular cell adhesion molecule 1 (VCAM-1) when compared to FLS isolated ...
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Influenza Virus Hemagglutinin Stalk Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model
... When we tested the in vivo protective effect of pooled sera from the study, we found that sera of adjuvanted H5N1 virus vaccinees were highly protective against challenge with H1N1pdm09 in the mouse model, which ...
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Efficacy and safety of sodium zirconium cyclosilicate in patients with baseline serum potassium level ≥ 5.5 mmol/L: pooled analysis from two phase 3 trials
... Hyperkalemia therapies (e.g., intravenous insulin and glu- cose or inhaled β2 agonists) typically used in the emergency department and other acute care settings to lower serum potassium (K + ) are temporary ...
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Effect of malaria on: Serum K, Serum Na and Blood urea- Sudan
... low serum potassium were 3 patients(4.3%.) and Simple malaria with low serum potassium was found in 9 ...low serum potassium . Heindricks et al reported that the reduction in the K+ levels was ...
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