K, kallikrein
Vascular remodeling and the kallikrein kinin system
... tissue kallikrein gene in mice induced endothelial dysfunction but not arterial ...diovascular kallikrein-kinin system may play a role in arterial and cardiac remod- eling and ...vascular ...
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Misfolded proteins activate Factor XII in humans, leading to kallikrein formation without initiating coagulation
... to kallikrein and BK ...while kallikrein activates both urokinase-type plas- minogen activator (uPA) and ...the kallikrein system (kallikrein-mediated plasmin formation) seems to be of ...
12
Studies on the prekallikrein (kallikreinogen)—kallikrein enzyme system of human plasma: II Evidence relating the kaolin activated arginine esterase to plasma kallikrein
... Another plasma arginine esterase with properties suggestive of permeability factor is activated by factor XII in the presence of synthetic substrates, but only at low ionic strength. The data suggest that this enzyme is ...
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Contribution of Plasma Protease Inhibitors to the Inactivation of Kallikrein in Plasma
... plasma kallikrein in normal plasma, there is little quantitative support for this ...purified kallikrein in normal plasma, as well as in plasma congenitally deficient in Cl-INH, or artificially depleted of ...
8
Plasma Kallikrein Activation and Inhibition during Typhoid Fever
... and kallikrein inhibitor, there was no change in factor XII clotting activity or antigenic concentrations of prekallikrein and the kallikrein inhibitors, C1 esterase inhibitor (C1-INH) and 2 ...
11
Urinary kallikrein and plasma renin activity as determinants of renal blood flow The influence of race and dietary sodium intake
... the kallikrein-kinin system and the renin-angiotensin system in the regulation of blood pressure, salt and water excretion, and renal blood ...urinary kallikrein activity was greater in white normotensives ...
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Detection of tissue kallikrein in the bronchoalveolar lavage fluid of asthmatic subjects
... samples from 17 asthmatics who either responded to aerosolized allergen challenge or had symptoms of active asthma. In contrast, six of seven normal controls lacked enzymatic activity. Levels of free immunoreactive kinin ...
11
Purified human plasma kallikrein aggregates human blood neutrophils
... plasma kallikrein resulted in PMN aggregation when kallikrein was present at concentrations ranging from ...microM). Kallikrein-induced PMN aggregation was not mediated through C5-derived peptides, ...
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Expression of Kallikrein-Related Peptidases (KLKs) in Adenoid Cystic Carcinoma
... This study is the first to quantify kallikrein expression in ACC and NSGT from FFPE extracts. As previously discussed, the expression of individual kallikreins was normalized to β-actin in each sample and ...
87
Expression Of Human Kallikrein Protein And mRNA In Maxillofacial Cysts And Tumours
... Kallikreins have been identified in a variety of tissues at the mRNA and protein levels (21). Some tissues (such as salivary glands, skin and the central nervous system) express multiple kallikrein proteins. As a ...
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Urinary Kallikrein Excretion in Essential and Mineralocorticoid Hypertension
... urinary kallikrein excretion of patients with LREH ...Urinary kallikrein was decreased in black ...urinary kallikrein was not significantly decreased in either black hypertensive ...
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Inactivation of kallikrein in human plasma
... plasma kallikrein is inactivated by plasma protease ...of kallikrein. Therefore, the kinetics of kallikrein inactivation and the formation of kallikrein inhibitor complexes were studied in ...
11
Biomarker implication of kallikrein-related peptidases as prognostic tissue substrates of poor survival in colorectal cancer
... hydrolyze peptide bonds, playing important and vital role in cell growth regulation, invasion, and angiogen- esis [4]. Among all serine proteases within the human genome, the kallikrein and ...
11
Separation of Plasma Thromboplastin Antecedent from Kallikrein by the Plasma α2 Macroglobulin, Kallikrein Inhibitor
... intrinsic coagulation system, and plasma kallikrein has been implicated as a mediator of the inflammatory process. Whereas their biologic activities are functionally distinct, their identity as separate entities ...
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The mouse glandular kallikrein gene family
... The similarity of these proteases to glandular kallikreins from other sources further emphasises that Y-NGF, EGF-BP and [I S-NGF endopeptidase kallikrein belong to the same enzyme /t fam[r] ...
210
Immunochemical Studies of Plasma Kallikrein
... plasma kallikrein has been prepared in rabbits with kallikrein further purified to remove gamma ...of kallikrein preparation with ...Both kallikrein and prekallikrein (in plasma) cross-react ...
12
Inhibitors of Kallikrein in Human Plasma
... Human plasma was fractionated by ammonium sulfate precipitation, DEAE-cellulose chromatography, and Sephadex G-200 gel filtration to determine which method would give the greatest number of clearly separable ...
14
Amiloride inhibits mammalian renal kallikrein and a kallikrein like enzyme from toad bladder and skin
... urinary kallikrein or of rat renal cortical cells upon a synthetic substrate (ID50 = ...of kallikrein acting upon kininogen substrates was also inhibited by amiloride, as measured by bioassay in the rat ...
9
Chemotactic activity derived from interaction of factors D and B of the properdin pathway with cobra venom factor or C3B
... mixtures yielding CoVFB correlated with their hemolytic activity. Pretreatment of neutrophils with mixtures containing CoVFB rendered them unresponsive to subsequent chemotactic stimulation by kallikrein of C5a, ...
7
Tissue factor is a major stimulus for vegetation formation in enterococcal endocarditis in rabbits
... Intrinsic coagulation pathway activation was assessed by measuring the conversion of prekallikrein to kallikrein, a Factor XII.-dependent reaction, while plasma was incubated over a glas[r] ...
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