κ-opioid receptor
Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor
... NK1 receptor antagonist L-733,060 did not show any additional positive effect against neuroprotective activity by GRe, indicating that NK1 receptor is also one of the molecular pharmacological targets for ...
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κ-Opioid receptor stimulation reduces palmitate-induced apoptosis via Akt/eNOS signaling pathway
... considerable κ-opioid receptor (κ-OR) expression exists in vascular endothelium ...of κ-OR with U50,488H directly dilates vessel in an NO-dependent manner ...whether κ -OR ...
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Structure of the human κ-opioid receptor in complex with JDTic.pdf
... their receptor inter- action modes, as supported by differential effects of various site-directed mutations on the binding properties of chemically diverse prototypic ...understanding opioid drug action, ...
8
Activation of κ-opioid receptor by U50,488H improves vascular dysfunction in streptozotocin-induced diabetic rats
... that opioid receptors are widely distributed in the cardiovascular system ...[40]. Opioid receptors, especially KOR, have many cardiovas- cular protective effects, such as reducing myocardial ...
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Dynorphin regulates the phagocytic activity of splenic phagocytes in wall lizards: involvement of a κ opioid receptor coupled adenylate cyclase–cAMP–PKA pathway
... G-protein-coupled receptor (GPCR) superfamily (Law et ...different opioid receptors (Lawrence and Bidlack, 1993; Sharp et ...same opioid receptor (Bohn et ...of receptor-coupled ...
6
Roles of residues 3 and 4 in cyclic tetrapeptide ligand recognition by the Κ opioid receptor
... of receptor–ligand complexes, two complementary approaches can be applied to uncover the molecular details of receptor– ligand ...the receptor-bound conformation of the ligands, based on ...
10
Novel signaling of dynorphin at κ opioid receptor/bradykinin B2 receptor heterodimers
... 5-HT2A receptor agonists activate both Gq and Gi proteins when the 5-HT2A receptor forms heteromers with the mGlu2 receptor [58, ...orexin receptor 1 and KOR can form a heterodimer, which ...
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Role of μ-opioid receptor in parafascicular nucleus of thalamus on morphine-induced antinociception in a rat model of acute trigeminal pain
... μ-opioid receptor in the present ...that opioid receptors are widely distributed throughout brain with particularly high density in limbic structures, thalamic nuclei and cerebral ...μ-opioid ...
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ROLE OF VARIOUS OPIOID RECEPTORS IN OPIOID DEPENDENCE AND WITHDRAWAL SYNDROME
... and κ opioid receptor as pentazocine which is an antagonist of μ opioid receptor and agonist of κ and σ receptors could induce withdrawal syndromes but ketamine which acts as ...
5
Nalfurafine hydrochloride to treat pruritus: a review
... an opioid κ-selective agonist, has been officially approved for resistant pruritus in HD patients on the basis of a well-evidenced clinical trial in ...binding κ-opioid receptors, suggesting ...
7
Laxative effects and mechanism of action of Brazilian green propolis
... The effect of propolis on constipation has not been previously reported, but its use in traditional, not scien- tifically demonstrated, medicine indicates that it may have a laxative effect. Propolis can also have ...
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Interactions between opioid agonists and glutamate receptor antagonists
... assessed. As mentioned above, the behavioral effects of two drugs may depend on the experimental endpoint under study and on the proportion of drugs in the mixture (Gessner and Cabana, 1970; Tallarida, 2000; Stevenson et ...
131
<p>Emerging roles of microRNAs in morphine tolerance</p>
... Arrestins are inhibitory proteins, and β -arrestin 2 is a - subtype 49 that can activate GPCRs to mediate internalization and desensitization of MOR. Upregulated β -arrestin 2 func- tions on MOR to attenuate the ...
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Journal of Applied Pharmaceutical Science
... involved opioid receptor (Meotti et ...with opioid system, as their analgesic effects were inhibited by opioid receptor antagonists (Berrocoso et ...
5
Original Article Preoperative intravenous administration of dezocine for cesarean section under epidural anesthesia: effects on maternal well-being and neonatal outcome
... the κ receptor, which produced analgesic and seda- tive activities; this receptor is mainly found in the brain, brainstem, and spinal cord ...spinal κ recep- tor in advance, thereby improving ...
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<p>Peripheral Opioid Receptor Antagonists for Opioid-Induced Constipation: A Primer on Pharmacokinetic Variabilities with a Focus on Drug Interactions</p>
... Oral naloxone is available in the fi xed-dose oral combina- tions of oxycodone/naloxone prolonged-release formulation, 51 buprenorphine/naloxone, 52 and pentazocine/naloxone. 53 Oxycodone/naloxone was approved but not ...
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Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects
... for opioid sensitivity, and 56 healthy volunteers were recruited for the ...and opioid side effects and symptoms were measured in both patients and controls using the EORTC-OLQ-30 ...for opioid ...
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Endorphinergic Attenuation of Distress by Concomitantly Enhancing Endogenous Opioid Release and Switching Opioid Receptor Signaling from an Excessively Excitatory to a Normal Inhibitory Mode
... of opioid peptides and excitatory amino acids in a variety of popular ...the opioid peptides that can be released by endorphin enhancers, ...that opioid peptides, known as exorphins, are also present ...
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Kappa opioid receptor signaling protects cartilage tissue against posttraumatic degeneration
... Modern opioid analgesics mainly drive their therapeutic effect through 3 classic opioid receptors: kappa opioid receptor (KOR), delta opioid receptor (DOR), and mu opioid ...
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Regulation of opioid receptor signalling: Implications for the development of analgesic tolerance
... that receptor stimu- lation by morphine and by more efficacious ligands are all capable of inducing functional desensitization of MOR-mediated neural ...protein receptor kinase 2 (GRK2) and arrestin2 ...
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