K-ras
Impact of Mutations on K Ras p120GAP Interaction
... with Ras Switch I and Switch II regions (containing amino acids 30 - 40, and 60 - 70, respectively), and stabilizes these two regions dur- ing the hydrolytic process (Figure ...the K-Ras Switch I ...
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Relationship of the K-ras/c-mos Expression Patterns With Angiogenesis in Non-Small Cell Lung Carcinomas
... the K-ras(No)/ c-mos(P) pattern is related to vessel regression, which acts in a particular stage of tumor develop- ment as a negative selective-pressure mechanism, by creating a hypoxic ...the ...
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Selective killing of K-ras–transformed pancreatic cancer cells by targeting NAD(P)H oxidase
... After rehydration, PBS was removed. Then, 1 × 10 5 par- ental or K-ras –transformed E6E7 cells and Capan-1, AsPC-1, Panc-1 cells in 0.5 mL of supplement-free medium with or without 10 μmol/L capsaicin were ...
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Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer
... model, K-Ras appeared to lower ROS level through increased transcription of Nrf2 (NF-E2-related factor 2) [26], a critical transcription factor of a number of major antioxidants that protect cells from ...
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GGTase I deficiency reduces tumor formation and improves survival in mice with K RAS–induced lung cancer
... and K-RAS–induced cancer development in ...oncogenic K-RAS was switched on in lung cells and myeloid ...treat K-RAS–induced ...
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Case Report: Long Term Survival in Patient with Cirrhosis of the Liver and Colon Cancer K ras Wild Type
... The K-ras oncogene is a central component of the system of signal transduc- tion downstream of EGFR and plays a critical role in the regulation of cell ...
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Conditional expression of oncogenic K ras from its endogenous promoter induces a myeloproliferative disease
... showed marked extramedullary hematopoiesis with ef- facement of splenic architecture and expansion of the red pulp compartment by varying degrees of granulocytic, monocytic, erythroid, and megakaryocytic lineage cells ...
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Original Article The mutations of K-ras and BRAF gene in colorectal carcinoma and its clinical significance
... obtain K-ras gene mutation by detecting 48 cases Chinese CRC ...that K-ras gene mutation had no relationship with some parameters such as age, gender, tumor size and site as well as TNM ...
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Leukemia associated NOTCH1 alleles are weak tumor initiators but accelerate K ras–initiated leukemia
... Gain-of-function NOTCH1 mutations are found in 50%–70% of human T cell acute lymphoblastic leukemia/ lymphoma (T-ALL) cases. Gain-of-function NOTCH1 alleles that initiate strong downstream signals induce leukemia in ...
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Phenotypic classification of gastric signet ring cell carcinoma and its relationship with K-ras mutation.
... of K-ras mutation was significantly lower among MUC5AC- positive tumors than MUC5AC-negative malignancies ...lower K-ras mutation rate than those negative for this marker ...of ...
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Mutations in the K ras oncogene induced by 1,2 dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa
... activating K-ras or H-ras oncogenes, induced by the procarcinogen 1,2-dimethylhydrazine (DMH), were detectable in preneoplastic or neoplastic rat colonic ...carcinomas. Ras mutations were ...
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Methylation associated inactivation of RASSF1A and its synergistic effect with activated K-Ras in nasopharyngeal carcinoma
... The Ras family proteins are a group of mem- brane-bound small GTPase which comprise 21 members such as H-Ras, K-Ras and ...of Ras, RASSF1A may shift the balance of Ras signaling ...
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Original Article MicroRNA-143 shows tumor suppressive effects through inhibition of oncogenic K-Ras in pituitary tumor
... miR-143. K-Ras was identified as one of the potential targets of miR-143 and caught our ...with K-Ras 3’ untrans- lated region is illustrated in Figure ...
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Original Article MiR-181d functions as a potential tumor suppressor in oral squamous cell carcinoma by targeting K-ras
... for K-ras and the normalization con- trol gene glyceraldehyde 3-phosphate dehydro- genase (GAPDH) were performed using SYBR Premix Ex Taq (TaKaRa) on an ABI PRISM 7500 Sequence Detection System (Applied ...
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Removal of High Molecular Weight DNA by Carboxylated Magnetic Beads Enhances the Detection of Mutated K ras DNA in Urine
... (Qiagen, Valencia, CA, USA), 0.5 U Hot-Start Taq (Qiagen), 200 µ M dNTP, 0.1 µ M primers: L-Ext (5 GCT CTT CGT GGT GTG GTG TCC ATA TAA ACT TGT GGT AGT TGG ACC T 3 ) and R-Ext (5 GCT CTT CGT GGT GTG GTG TCC CGT CCA CAA ...
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The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the Apc Min/+mouse small intestine
... mouse K-ras 4A upstream primer (5'-CCTGGTAGGGAATAAGTGT- GATTTG-3'), and downstream primer (5'-GTACTGTCG- GATCTCTCTCACCAAT-3'); mouse K-ras 4B upstream primer (5'-GAGTAAAGGACTCTGAAGATGTGCC-3') ...
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Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer
... of K-Ras/MEK/ERK-dependent ...radiosensitizing K-RASmut NSCLC cells, indicating that dual targeting of PI3K and MEK is an efficient approach to improve radiotherapy ...
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MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma
... prediction, K-Ras was identified as one of the potential targets of ...with K-Ras 3 ′ untranslated region is illustrated in Figure ...that K-Ras is the direct target of miR-206 ...
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The prognostic impact of K-RAS mutations in adult acute myeloid leukemia patients treated with high-dose cytarabine
... PCR was performed in glass capillary tubes using 1 µ L of genomic DNA and LightMix Kit K-RAS codons 12/13 (Roche Diagnostics) with final volume of 20 µ L. The PCR program started with incubation at 95 ° C ...
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Isolation of Transformation Suppressor Genes by cDNA Subtraction: Lumican Suppresses Transformation Induced by v-src and v-K-ras
... Introduction of a single oncogene into primary cells is not sufficient to produce full transformation (21, 22, 27, 35). For tumorigenic transformation of primary cells, either a collabo- ration between two oncogenes such ...
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