Kainate receptor
Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice
... (FMRP). Kainate receptor (KAR) is a subfamily of ionotropic glutamate receptors (iGluR) that acts mainly as a neuromodulator of synaptic transmission and neuronal ...
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Cerebellar cortical AMPA/kainate receptor blockade prevents performance of classically conditioned nictitating membrane responses
... Classical conditioning of the nictitating membrane–eye blink response of rabbits is a simple form of associative motor learning. Lesion studies have shown that performance of learned responses is dependent on the ...
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A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort
... Rodent behavioural studies have provided additional evidence that GluK4 receptor subunit function contributes to neuropsychiatric phenotypes and memory function. For example, GluK4 knockout mice demonstrate ...
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Cortical kainate receptors and behavioral anxiety
... KA receptor subunits are widely expressed in the cortex ...KA receptor subunits are expressed in the ACC ...KA receptor mediated synaptic responses have also been re- ported in ACC and IC [3, ...KA ...
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Genome wide identification, characterization and classification of ionotropic glutamate receptor genes (iGluRs) in the malaria vector Anopheles sinensis (Diptera: Culicidae)
... receptors, Kainate receptors and NMDA (N-me- thyl-D-aspartate) receptors, ...and Kainate receptors are further grouped to- gether as non-NMDA ...while Kainate receptors have a sub- tler modulatory ...
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N-methyl-D-aspartate (NMDA) receptor expression and function is required for early chondrogenesis
... (AMPA), kainate, and N-methyl-D-aspartate receptors ...and kainate receptors, in- cluding voltage-sensitive blockade by Mg 2+ , high perme- ability to Ca 2+ , requirement of glycine as a coagonist, and ...
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Regulation of Ion Channel and Transporter Function Through RNA Editing
... the receptor less sensitive to further stimulation, a process known as ...acid receptor (AMPA) receptors, kainate receptors, and N-methyl-d-aspartate (NMDA) ...and kainate receptors because ...
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Nimesulide limits kainate-induced oxidative damage in the rat hippocampus
... of kainate toxicity support the hypothesis that the main cause of neurotoxicity is the activation of presynaptic kainate receptors and the release of endogenous glutamate (Ferkany et ...Further, ...
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A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia
... To model the down-regulation of ADAR2 in patients with mental disorders, we analyzed Adar2 +/− mice. Al- tered RNA editing of Htr2c was characterized by a rela- tively large decrease at the D site with smaller changes at ...
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Glutamate as a Neural Stress Factor in Humans and Animals
... and kainate receptors (ligand gated calcium channels) and III groups of the metabotropic glutamate receptors (mGluR 1-8 ) family members (G-protein coupled ...
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Intracellular Ca2+ release mediated by metabotropic glutamate receptor activation in the leech giant glial cell
... hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors by reference to their artificial agonists (Nakanishi, 1992; Watkins et al. 1990). Metabotropic glutamate receptors (mGluRs) are coupled to ...
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A gain-of-function mutation in the GRIK2 gene causes neurodevelopmental deficits
... Results: A single de novo point mutation in the GRIK2 gene was identified as causative for the neurologic symptoms of the proband. The mutation is predicted to change a codon for alanine to that of a threonine at ...
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Novel hypoglycemic injury mechanism: N methyl D aspartate receptor mediated white matter damage
... Our conclusion is supported by the following observations: 1 hypoglycemic injury was significantly blocked by NMDAR antagonists but minimally by AMPA/kainate receptor antagonists, 2 aspa[r] ...
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Application of computational approaches to study signalling networks of nuclear and Tyrosine kinase receptors
... and Receptor tyrosine kinases (RTKs) are essential proteins in many cellular processes and sequence variations in their genes have been reported to be involved in many diseases including ...
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Immunological and virological investigations into sporadic ovine lymphoma : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy at Massey University
... surface membrane immunoglobulin receptor for aggregated IgG receptor for antibody- coated bovine erythrocytes receptor for antibody-coated human erythrocytes receptor for erythrocyte - a[r] ...
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The structure and function of the CGRP receptor
... In RAMP1, mutations of Y66A, L69A and T73A in helix 2, P85A, N86A in the loop from helix 2 to helix 3, and H97A and F101A in helix 3 all impaired cAMP production (Figure 1.12). The crystal structure shows that RAMP1 Y66 ...
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Expression of the endoplasmic reticulum molecular chaperone (ORP150) rescues hippocampal neurons from glutamate toxicity
... A series of events initiated by glutamate-receptor interaction perturbs cellular homeostasis resulting in elevation of intracellular free calcium and cell death. Cells subject to such environmental change express ...
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Rambold, Angelika (2008): Funktionelle Charakterisierung des Prion-Proteins: physiologische Aktivität und pathophysiologische Alteration. Dissertation, LMU München: Fakultät für Biologie
... To monitor apoptosis transiently transfected SH- SY5Y cells expressing either wt PrP or GPI-anchored GFP were exposed to kainate for 4 h and apoptotic cell death was analyzed by indirect[r] ...
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(R)-[11C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus
... of kainate, which leads to development of spontaneous seizures after 3 weeks to 3 ...in kainate and saline (control) treated rats, at 7 days after ...
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Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica
... Toll-like receptor 1 TLR2 Toll-like receptor 2 TLR3 Toll-like receptor 3 TLR4 Toll-like receptor 4 TLR5 Toll-like receptor 5 TLR6 Toll-like receptor 6 TLR7 Toll-like ...
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