Kainic Acid
Original Article Role of endoplasmic reticulum stress-associated gene TRIB3 in rats following kainic acid-induced seizures
... following kainic acid- induced seizures (Figure 2A, 2B), the results suggesting that induction of ER stress may be related to seizure-induced hippocampal ...
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Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation
... Our data also showed that sesamin extract had the ten- dency to decrease the severity of seizure behavior. A recent study indicated the lack of effectiveness of antioxi- dants in the kainic acid SE model ...
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Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury
... KA: Kainic acid; LPC: Lysolecithin; MS: Multiple sclerosis; NGF: Nerve growth factor; NG2: Chondroitin sulphate proteoglycan neuron/ glia antigen 2; NPCs: Neural progenitor cells; NSCs: Neural stem cells; ...
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The Ketogenic Diet Suppresses the Cathepsin E Expression Induced by Kainic Acid in the Rat Brain
... ribonucleic acid; RT- PCR, reverse transcription polymerase chain reaction; NS-ND, normal saline, normal diet; NS-KD, normal saline, ketogenic diet; KA-ND, kainic acid, normal diet; KA- KD, ...
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Original Article Effect of intra-cisternal application of kainic acid on the spinal cord and locomotor activity in rats
... Abstract: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease of idiopathic etiology. Glutamate ex- citotoxicity is one of the proposed hypotheses causing progressive death of motor neurons. We aimed to ...
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Effects of Celastrus paniculatus Willd. and Sida cordifolia Linn. in Kainic Acid Induced Hippocampus Damage in Rats
... in kainic acid induced neurodegenerative ...control, kainic acid, kainic acid + seed oil of Celastrus paniculatus (SOCP), kainic acid + aqueous root extract of Sida ...
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Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid
... that kainic acid not only induced neurodegeneration but also arouse several caspase 3-mediated molecular and cellular changes including dendritic plasticity, neurogenesis, and ...rescue kainic ...
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Kainic Acid, NMDA and Bicuculline Induce Elevation in Concentrations of Glutathione and Amino Acids in Vivo: Biomarkers for Seizure Predisposition?
... The present study was carried out to investigate the effect of NMDA, bicuculline and kainic acid (KA) on the extracellular concentration of glutathione, phosphoethanolamine (PEA) and taurine in rat ...
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Preventive Effect of Resveratrol against Brain Mitochondria DNA Damage, Lipid Peroxidation, Inflammation and Seizures Induced by Kainic Acid in Mice
... against kainic acid-induced epilepsy in Swiss albino mice by determination of various parameters including serum sialic acid (SA), tumor necrosis factor alpha(TNF-α) and interleukin- 1 beta (IL-1β) ...
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The Synthesis of Heterocycles and Carbocycles and Work Towards Kainic Acid
... of kainic acid, the compound received attention from chemists and biologist due to its neuroexcitatory ...L-glutamic acid (1-232h), which is the most abundant excitatory neurotransmitter, interacts ...
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Diffusion weighted MR in experimental sustained seizures elicited with kainic acid
... of kainic acid was used to induce sustained limbic seizures in seven ...after kainic acid–induced seizures, and at 24 hours, 3 days, and 7 days after the kainic acid ...after ...
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RNAseq analysis of hippocampal microglia after kainic acid-induced seizures
... Microglia have been shown to be of critical importance to the progression of temporal lobe epilepsy. However, the broad transcriptional changes that these cells undergo following seizure induction is not well understood. ...
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The Effects of Kainic Acid-Induced Seizure on Gene Expression of Brain Neurotransmitter Receptors in Mice Using RT2 PCR Array
... Introduction: Kainic acid (KA) induces neuropathological changes in specific regions of the mouse hippocampus comparable to changes seen in patients with chronic temporal lobe epilepsy ...of kainic ...
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Pu-Erh tea and GABA attenuates oxidative stress in kainic acid-induced status epilepticus
... Pu-erh tea is one of the most widely consumed bev- erages in the Orient. In recent years, studies the possible investigating health benefits of Pu-erh tea have shown salutary effects on oxidative stress, cancer, ...
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A kainic acid-induced status epilepticus model of epileptogenesis in the C57BL/6J mouse. Interventions targeting nitric oxide and NMDA receptor-mediated pathophysiology
... The NMDAR acts as a coincidence detector, activated only when the membrane is simultaneously depolarized and activated by glutamate, allowing it to reinforce signals that are close in space or time. NMDAR, in the open ...
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Sub region-specific modulation of synchronous neuronal burst firing after a kainic acid insult in organotypic hippocampal cultures
... Imaging of NeuN (neuron specific antibody) labeled cul- tures revealed that the absence of CA3 activity was not due to loss of CA3 pyramidal cells at the 24 hour time-point (Fig. Differe[r] ...
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Everolimus is better than rapamycin in attenuating neuroinflammation in kainic acid-induced seizures
... mTOR is regulated by the upstream Akt pathway and the AMPK pathway [14]. Inhibition of ERK phosphoryl- ation by everolimus observed in the present study is consistent with an earlier study [40]. In a previous study of ...
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Kainic acid-induced microglial activation is attenuated in aged interleukin-18 deficient mice
... Interestingly, even though the number of activated microglia is smaller in KA-treated IL-18 KO mice than in KA-treated WT mice, the proportion of microglia cells that express the cytokin[r] ...
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Investigating the effects of targeting nitric oxide pathways in a kainic acid mouse model of epileptogenesis
... When PSD95BP was administered to KA-treated animals, phosphotidate cytidylyltransferase 1 (Cds1) and basigin were down-regulated, and gene model 1604B was significantly up-regulated in comparison to control (Table 5.7 ...
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Increased Seizure Susceptibility in a Mouse with Diacylglycerol Kinase β Deficiency
... To investigate whether DGKβ KO mice might have ab- normal susceptibility to another drug that induces seizure, we used kainic acid. This is an agonist for kainate-class ionotropic glutamate receptors, and ...
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