KAL, kallikrein
Misfolded proteins activate Factor XII in humans, leading to kallikrein formation without initiating coagulation
... dependent kallikrein generation, whereas freshly dissolved control BSA did not (Figure 2, G and H, ...FXII-dependent kallikrein generation (Supplemental Figure 2, A–H, ...
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Studies on the prekallikrein (kallikreinogen)—kallikrein enzyme system of human plasma: II Evidence relating the kaolin activated arginine esterase to plasma kallikrein
... Based on this probable identification, evidence is provided that the concentration of active factor XII determines the rate of activation of plasma kallikreinogen, and that the activation may be blocked by polybrene. ...
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Contribution of Plasma Protease Inhibitors to the Inactivation of Kallikrein in Plasma
... plasma kallikrein in normal plasma, there is little quantitative support for this ...purified kallikrein in normal plasma, as well as in plasma congenitally deficient in Cl-INH, or artificially depleted of ...
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Plasma Kallikrein Activation and Inhibition during Typhoid Fever
... and kallikrein inhibitor, there was no change in factor XII clotting activity or antigenic concentrations of prekallikrein and the kallikrein inhibitors, C1 esterase inhibitor (C1-INH) and 2 ...
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Urinary Kallikrein Excretion in Essential and Mineralocorticoid Hypertension
... urinary kallikrein excretion of patients with LREH ...Urinary kallikrein was decreased in black ...urinary kallikrein was not significantly decreased in either black hypertensive ...
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Vascular remodeling and the kallikrein kinin system
... tissue kallikrein gene in mice induced endothelial dysfunction but not arterial ...diovascular kallikrein-kinin system may play a role in arterial and cardiac remod- eling and ...vascular ...
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Expression Of Human Kallikrein Protein And mRNA In Maxillofacial Cysts And Tumours
... Non-inflammatory odontogenic cysts and tumours vary in clinical appearance and can cause widespread destruction and deformation of the face. Proteases may play a role in the differing pathogenesis of these cysts and ...
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Expression of Kallikrein-Related Peptidases (KLKs) in Adenoid Cystic Carcinoma
... The kallikrein family constitutes the largest cluster of proteases within the human genome, and all 15 KLK genes are encoded in tandem on chromosome 19q13.3-13.4 (47). All KLKs share similarities in their DNA ...
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Purified human plasma kallikrein aggregates human blood neutrophils
... than kallikrein (0.18 microM). Kallikrein was a potent aggregant agent for PMN because similar responses were observed with kallikrein ...with kallikrein resulted in stimulation of their ...
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The mouse glandular kallikrein gene family
... The similarity of these proteases to glandular kallikreins from other sources further emphasises that Y-NGF, EGF-BP and [I S-NGF endopeptidase kallikrein belong to the same enzyme /t fam[r] ...
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Detection of tissue kallikrein in the bronchoalveolar lavage fluid of asthmatic subjects
... samples from 17 asthmatics who either responded to aerosolized allergen challenge or had symptoms of active asthma. In contrast, six of seven normal controls lacked enzymatic activity. Levels of free immunoreactive kinin ...
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Separation of Plasma Thromboplastin Antecedent from Kallikrein by the Plasma α2 Macroglobulin, Kallikrein Inhibitor
... intrinsic coagulation system, and plasma kallikrein has been implicated as a mediator of the inflammatory process. Whereas their biologic activities are functionally distinct, their identity as separate entities ...
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Biomarker implication of kallikrein-related peptidases as prognostic tissue substrates of poor survival in colorectal cancer
... hydrolyze peptide bonds, playing important and vital role in cell growth regulation, invasion, and angiogen- esis [4]. Among all serine proteases within the human genome, the kallikrein and ...
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Amiloride inhibits mammalian renal kallikrein and a kallikrein like enzyme from toad bladder and skin
... addition, kallikrein-like enzyme activity was discovered in the urinary bladder or skin of Bufo marinus toads and this activity was also inhibited by ...glandular kallikrein-kinen system and renal ion and ...
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Inactivation of kallikrein in human plasma
... plasma kallikrein is inactivated by plasma protease ...of kallikrein. Therefore, the kinetics of kallikrein inactivation and the formation of kallikrein inhibitor complexes were studied in ...
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Immunochemical Studies of Plasma Kallikrein
... plasma kallikrein has been prepared in rabbits with kallikrein further purified to remove gamma ...of kallikrein preparation with ...Both kallikrein and prekallikrein (in plasma) cross-react ...
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Inhibitors of Kallikrein in Human Plasma
... Human plasma was fractionated by ammonium sulfate precipitation, DEAE-cellulose chromatography, and Sephadex G-200 gel filtration to determine which method would give the greatest number of clearly separable ...
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Ecallantide is a novel treatment for attacks of hereditary angioedema due to C1 inhibitor deficiency
... In the initial Phase I study, subjects received dose- ranging intravenous (IV) infusions. Peak concentrations occurred 2 to 3 hours after subcutaneous (SC) admin- istration, although absorption was slightly slower in ...
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Inhibition of thrombin generation in human plasma by phospholipid transfer protein
... Fatty acid-free bovine serum albumin (BSA) was pur- chased from Calbiochem (San Diego, CA). Human factor XIa and corn trypsin inhibitor were from Hematologic Technologies Inc. (Essex Junction, VT). Human factor XII, ...
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Inhibition by CāINH of Hageman Factor Fragment Activation of Coagulation, Fibrinolysis, and Kinin Generation
... The inhibition of prealbumin Hageman factor fragments observed was dependent upon the time of interaction of the fragments with CāINH and not to an effect upon kallikrein or plasmin gene[r] ...
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