KATP Channels
High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels
... ischemic threshold of angina patients during exercise with a trend toward increased exercise duration [2]. Intracoronary administration of fasudil increased oxygen saturation in coronary sinus vein, and ameliorated ...
9
Disrupting KATP channels diminishes the estrogen-mediated protection in female mutant mice during ischemia-reperfusion
... potassium channels (KATP) are known to play a pivotal role in conferring protection to the heart ...These channels remain closed under normal physiological conditions but they open in response to ...
15
Roles of energy status, KATP channels and channel arrest in fish brain K+ gradient dissipation during anoxia
... sensitive ectotherm, fails to display any response to glibenclamide. This suggests that the lack of glibenclamide effects in crucian carp could have phylogenetic grounds rather than being a reflection of anoxia ...
6
A role for nitric oxide in hypoxia induced activation of cardiac KATP channels in goldfish (Carassius auratus)
... The role of endogenous NO generation in the regulation of myocardial energetics in mammals has been studied extensively in recent years (Kelly et al., 1996). Each of the three principal isoforms of nitric oxide synthase ...
9
Increase of ATP-sensitive potassium (KATP) channels in the heart of type-1 diabetic rats
... KATP: ATP-sensitive potassium channels; HR: heart rate; STZ: streptozotoxin; CO: cardiac output; i.p.: intraperitoneal; HG: high glucose; PBS: phosphate- buffered saline; BSA: bovine serum albumin; RIPA: ...
9
Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes
... ) channels and PKC to confer cytoprotection against necrotic and apoptotic cell ...ATP channels remains unresolved, and the mitochondrial phosphoprotein(s) that mediate cytoprotection by PKC remain to be ...
14
Lidocaine relaxation in isolated rat aortic rings is enhanced by endothelial removal: possible role of Kv, KATP channels and A2a receptor crosstalk
... Lidocaine has also been shown to exert a number of vasomodulatory properties in isolated vessels including: 1) endothelium-independent relaxation [12, 13], and 2) vascular smooth muscle relaxation [12, 14, 15] or con- ...
11
Lipophilicity predicts the ability of nonsulphonylurea drugs to block pancreatic beta cell KATP channels and stimulate insulin secretion: statins as a test case
... ATP channels as an explanation for the adverse meta- bolic actions seen with chronic use of these ...these channels are majorly closed under phys- iological ...
10
Adenosine relaxation in isolated rat aortic rings and possible roles of smooth muscle Kv channels, KATP channels and A2a receptors.
... membrane hyperpolarization, and relaxation, which may have involved common protein kinase signalling transduc- tion pathways and crosstalk [50, 57, 62–66]. Membrane hyperpolarization of only a few millivolts can lower ...
11
Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice
... ) channels rather than sarcolemmal K ATP (sarcK ATP ) channels are important as end effectors and/or triggers of ischemic preconditioning ...ATP channels, we conducted functional experiments using ...
9
Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 KATP channels
... nifedipine infusion had a marked reduction in the num- ber of ST segment elevations in the first 48 hours of ECG recording (210 ± 11 events/d in sham-infused vs. 66 ± 12 events/d in nifedipine-infused mice; P < ...
7
Protective role of neuronal KATP channels in brain hypoxia
... Subpopulations of mammalian neurons (Ballanyi et al., 1996a; Richter and Ballanyi, 1996) are highly tolerant to anoxia in a fashion similar to brain structures of some cold- blooded vertebrates (Lutz and Nilsson, 1994; ...
12
Activation of KATP channels suppresses glucose production in humans
... ) channels in rodents, whether these central pathways contribute to regulation of EGP in humans remains to be ...ATP channels may be an important regulator of EGP in humans and that this pathway could be a ...
6
Significance of KATP channels, L-type Ca2+ channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles In vivo
... 2+ channels are only one of several Ca 2+ entry mechanisms in VSMCs, and it is therefore not surprising that the vessels are able to re- tain tone despite the presence of ...L-type channels appears to be ...
11
Memantine has no effect on KATP channels in pancreatic β cells
... Memantine had no effect on the blood glucose level, insulin secretion from isolated islets or KATP channel current in pancreatic β cells.. Keywords: KATP channel, Memantine, Pancreatic [r] ...
6
Intracellular ATP can regulate afferent arteriolar tone via ATP sensitive K+ channels in the rabbit
... these channels in the presence of ATP, and this effect was also blocked by ...these KATP channels in the control of vascular tone, diazoxide was tested on isolated perfused ...for KATP ...
9
Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia
... Besides KATP channels, inhibitory effects of PNU- 37883A on voltage-dependent Ca 2+ channels were ob- served in a rat model of pinacidil (a cyanoguanidine compound opening ATP-modulated potassium ...
10
Central insulin action in energy and glucose homeostasis
... However, more detailed analyses complicate this view because a only 45% of unidentified ARC neurons follow this pattern 49; b activation of hypothalamic KATP channels by insulin is aboli[r] ...
7
Expression of ATP-sensitive potassium channels in human pregnant myometrium
... a KATP channel opener, inhibited the spontaneous contractility of pregnant myometrium, suggesting that the KATP channels are functional in human pregnant ...
7
Africans, Cherokees, and the ABCFM Missionaries in the Nineteenth Century: An Unusual Story of Redemption
... heteromeric channels in expression system with single channel conductance between typical ...Kir6.1 channels (Cole et ...such channels in real tissues is still ...Kir6.2 channels are ...
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