Kidney Fibrosis
Chlorogenic acid attenuates kidney fibrosis via antifibrotic action of BMP 7 and HGF
... of kidney injury. Kidney injury induces TGF- β production and TGF- β then binds to T β RII (TGF- β receptor type II) to activate T β RI (TGF- β receptor type ...prevents kidney fibrosis, ...
5
Type 1 angiotensin receptors on macrophages ameliorate IL 1 receptor–mediated kidney fibrosis
... of kidney diseases, type 1 angiotensin (AT1) receptors are present on the immune cells that infiltrate the renal ...renal fibrosis and found that macrophage-specific AT1 receptor deficiency exacerbates ...
7
RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase
... Pharmacological inhibition of ACL reduces UUO-induced kidney fibrosis. We next tested the potential of the AKT/ACL pathway as a therapeutic target in kidney fibrosis. TGF-β1 and AKT are ...
15
Effect of echinacoside on kidney fibrosis by inhibition of TGF-β1/Smads signaling pathway in the db/db mice model of diabetic nephropathy
... Abstract: Kidney fibrosis and renal tubular epithelial-to-mesenchymal transition (EMT) are the main pathological changes of diabetic nephropathy (DN), which eventually leads to end-stage renal ...on ...
14
Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis
... progressive kidney diseases remain poorly ...acute kidney injury ...of kidney fibrosis, the common pathway in CKD, has not been previously ...of kidney fibrosis, and primary ...
21
Original Article Chana 1 exhibits a promising role in the inhibition of renal kidney fibrosis in rat model
... For the regulation of kidney fibrosis and its pro- gression, TGF-β1 produced in the fibroblasts play an important role [17]. The cellular pro- cesses responsible for formation of fibers and their deposition ...
6
Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis
... Most studies to date have relied heavily on confocal microscopy and/or bone marrow transplanta- tion experiments. Discriminating myofibroblasts from hematopoietic lineage cells by confocal micros- copy is technically ...
15
Epithelial mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
... Epithelial-mesenchymal transition (EMT) has become widely accepted as a mechanism by which injured renal tubular cells transform into mesenchymal cells that contribute to the development of fibrosis in chronic ...
8
Silencing SMOC2 ameliorates kidney fibrosis by inhibiting fibroblast to myofibroblast transformation
... makes fibrosis a common end-feature of nearly all chronic inflammatory organ diseases, contributing to the morbidity and mortality of approximately half of the industrialized world ...The kidney is known ...
18
Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control
... progressive kidney fibrosis indicates the importance of these fatty acid–activated GPCRs in the mediation of kidney ...in kidney fibrosis, as observed with a sig- nificant increase of ...
13
OBSTRUCTIVE NEPHROPATHY OF KIDNEY STONE: The Role of Caspase-3, Transforming Growth Factor-β and Tumor Necrosis Factor-α in Kidney Fibrosis
... initial kidney injury induce cellular and molecular ...kidney fibrosis. Cellular and molecular pathophysiologic activation of kidney fibrosis is very complexes ...to kidney cells ...
8
CTGF in kidney fibrosis and glomerulonephritis
... proteinuria and mesangial expansion through functional impairment and loss of podocytes [18]. In a 16-week STZ-induced diabetic nephropathy model, CTGF heterozygous mice (CTGF +/ − ) with 50% lower CTGF expression ...
8
Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis
... Additionally, kidney sections were blocked with 10% donkey serum for 30 minutes and stained with LTL (FL1321, Vector Laboratories) for 30 minutes at room temperature for localization of renal epithelial cells ...
18
Pharmacological GLI2 inhibition prevents myofibroblast cell cycle progression and reduces kidney fibrosis
... Hh signaling controls the proliferation of diverse cell types during embryogenesis (56, 57) and regulates the proliferation of cancer cells (58–60), and mounting evidence implicates Hh/ GLI signaling in cell-cycle ...
18
Cellular and molecular mechanisms in kidney fibrosis
... Although fibrogenic processes in the interstitium promote organ demise through disruption of tubular functions, sclerotic changes in the glomerulus likely promote loss of the glomerular filtration barrier and ...
9
Chronic epithelial kidney injury molecule 1 expression causes murine kidney fibrosis
... healthy kidney, KIM-1 is undetectable, but after injury, it is induced more than any other protein, in which case it local- izes to the apical surface of surviving proximal tubule epithelial cells ...of ...
14
The effects of bee products on liver and kidney fibrosis of rats
... and kidney of rats treated with ethanol, which seem to be resulted from increased levels of ROS as a result of stress condition in the rats with ethanol ...
7
Progenitor-like cells derived from mouse kidney protect against renal fibrosis in a remnant kidney model via decreased endothelial mesenchymal transition
... Recent evidence has suggested that stem cells down- regulate the adhesion of flowing neutrophils or lympho- cytes and their subsequent transendothelial migration [26]. We observed evidence that the systemic injection of ...
12
Intrarenal microRNA signature related to the fibrosis process in chronic kidney disease: identification and functional validation of key miRNAs
... chronic kidney disease (CKD) has never been ...fresh kidney tissues of patients with biopsy-proven minimal change disease (MCD), focal segmental glomerular sclerosis (FSGS) and diabetic nephropathy (DN) by ...
13
Elevated serum concentrations of HE4 as a novel biomarker of disease severity and renal fibrosis in kidney disease
... renal fibrosis, which was upregulated in human and mouse fibrotic kidneys, through its capability as a protease inhibitor to suppress the activity of multiple proteases, such as serine proteases and matrix ...
12