Killer T Cells (TK Cells)
Natural killer T cells contribute to the control of acute retroviral infection
... Natural killer T cells (NKT cells) are innate-like T lym- phocytes, which recognize glycolipid antigens presented by the non-classical major histocompatibility complex (MHC) class ...
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Persistent Changes in Circulating and Intestinal gamma delta T Cell Subsets, Invariant Natural Killer T Cells and Mucosal Associated Invariant T Cells in Children and Adults with Coeliac Disease
... αβ T cells ...αβ T cells, evidence points toward an immunoregulatory role for Vδ1 cells ...Vδ1 cells expand in the coeliac gut in response to signals resulting from epithelial ...
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Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells
... rearranged T cell receptor loci in the germline and from splenic NKT cells from WT adult ...NKT cells in vitro and secreted large amounts of the Th1 cytokine ...NKT cells recapitulated the ...
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The Role of Natural Killer T Cells in Cancer-A Phenotypical and Functional Approach
... undergone T cell receptor (TCR) gene rear- rangement, as is the case with conventional T cells ...NKT cells. Type I NKT cells were first identified in mice in 1990 as a unique T ...
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Analysis of Invariant Natural Killer T Cells in Intra-Abdominal Sepsis
... spleens. T cells were also noted to be significantly increased in the omentum during IAS, corroborating observations made by Carlow et al [215] in a cecal ligation and puncture (CLP) model of polymicrobial ...
173
Natural killer T cells in adipose tissue prevent insulin resistance
... iNKT cells reside not only in AT (Figure 2) but also in the liver, and both organs are critically involved in the regulation of whole-body lipid and glucose homeostasis (34), we investigated circulating lipids and ...
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Natural killer cells and natural killer T cells in Lyme arthritis
... NK cells, patients with antibiotic-responsive arthritis had higher frequencies of iNKT cells in SF than PB, but these cells were often absent in SF in patients with antibiotic-refractory ...iNKT ...
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Exogenous Activation of Invariant Natural Killer T Cells by α Galactosylceramide Reduces Pneumococcal Outgrowth and Dissemination Postinfluenza
... We observed that IAV’s inhibitory effect was limited in time, since ␣-GalCer treatment at 14 dpi (during the viral recovery phase) and 21 dpi (data not shown) induced strong IFN- ␥ and IL-17A production by iNKT ...
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Targets for killer T cells.
... We feel therefore that it is legitimate to suggest that tumour asso- ciated antigens in man may in some cases form antigen complexes in association with 'seif HLA-SD antigens which are r[r] ...
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Transcriptional Control and Population Dynamics of Antiviral CD8+ T Cell Responses
... “killer” T cells is the destruction of virally infected target ...+ T cells also contribute to viral clearance through the release of proinflammatory cytokines, such as MIP-1alpha, ...
118
Cytoreduction surgery reduces systemic myeloid suppressor cell populations and restores intratumoral immunotherapy effectiveness
... Methods: To test these hypotheses, two representative intratumoral immunotherapies (an adenoviral vector encoding a suicide gene, AdV-tk, or a type-I interferon, Ad.IFN α ) were tested in murine models of lung ...
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The role of nonspecific cytotoxic cells and cytokine production in the pathogenesis of human intestinal diseases
... General Introduction 1.1 Characteristics of natural killer and killer cells 1 1.2 Killer cells and antibody-dependent cellular cytotoxicity 6 1.3 The origin and differentiation of natura[r] ...
327
Vahl, Johann Christoph (2013): TCR signals in the identity and function of mature NKT and regulatory T cells. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... NKT cells critically depend on their ability to rapidly secrete large amounts of many different immune-modulatory cytokines shortly after their ...NKT cells can be robustly activated in vivo to produce IFN- ...
125
Tumour draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC): the crucial contribution of immune cells (effector, regulatory) and cytokines (TH1, TH2) to immune mediated tumour cell death induced by NAC
... positive cells (brown membrane/cytoplasmic-stained cells) x intensity of staining (1 to 3)] was used to assess the level of expression; low was ≤ 100 and high was > ...
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Development of Natural Killer Cells Regulated by T-Box Transcription Factors
... NK cells remains ...NK cells (Kubota et ...NK cells through exposure to maternal or self- components with different or low levels of MHC molecules might be reasons that repertoire selection of NK ...
94
Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice
... Next, we compared the efficacy of dual JAKi + SYKi with anti-TNF therapy, a standard anti-rheumatic biological approach used in the clinics. Previous reports showed that anti-TNF prevents the development of very early ...
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Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity
... CD4+ T cells and promotes secretion of inflammatory cytokines and chemokines (particularly TNF- α and neutrophil chemo- attractant CXCL1), contributing to the development of acute renal inflammation ...
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Clinical applications of dendritic cells–cytokine-induced killer cells mediated immunotherapy for pancreatic cancer: an up-to-date meta-analysis
... Literature screening and data extraction were carried out by two independent reviewers (YZ and XZ), and disagreements were eliminated upon discussing with a third researcher (AZ). Extracted information included first ...
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Immunotherapy of Cancer—A Historical Note
... stimulated cells mediated cytotoxicity reactions by various killer cells: killer T (TK), natural killer (NK), lymphokine activated killer (LAK) ...stimulated ...
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Dynamics of Hepatitis B Virus Surface Antigen Level with Peripheral Blood Lymphocytes in Chronic Hepatitis B Infection
... Our study confirmed that there is an elevated ALT and AST level (values reflect clinical definition) in hepatitis B patients, when compared with healthy controls. Our results were in agreement with previous reports that ...
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