KKAy mice
Evaluating the antidiabetic effects of Chinese herbal medicine: Xiao Ke An in 3T3 L1 cells and KKAy mice using both conventional and holistic omics approaches
... Methods: The antidiabetic effect of XKA was first investigated in 3T3-L1 cells to study the effect of XKA on adipogenesis in vitro. Oil Red O staining was performed to determine the lipid accumulation. The intracellular ...
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Effects and mechanisms of resveratrol on the amelioration of oxidative stress and hepatic steatosis in KKAy mice
... non-treated KKAy mice developed severe oxi- dative stress and metabolic disorders in liver, leading to the unfavorable decreases of liver enzymes such as GPx, which is consistent with previous study ...
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Original Article Astragaloside effect on TGF-β1, SMAD2/3, and α-SMA expression in the kidney tissues of diabetic KKAy mice
... membranaceus that has multiple pharmaco- logical activities. Astragaloside and polysac- charide are the main monomer composition extracted from astragalus membranaceus. It has been found that astragalus membrana- ceus ...
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Effect of berberine on the renal tubular epithelial-to-mesenchymal transition by inhibition of the Notch/snail pathway in diabetic nephropathy model KKAy mice
... the mice in the metabolic ...model KKAy mice were randomly divided into model group (MG, n = 10) and treatment group (TG, n = 10), with an equivalent distribution of average body weights and blood ...
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The albumin-exendin-4 recombinant protein E2HSA improves glycemic control and β-cell function in spontaneous diabetic KKAy mice
... Nevertheless, GLP-1 itself is not appropriate for clin- ical use, having a short half-life (1 – 2 min) due to rapid degradation by dipeptidyl peptidase-4 and neutral endo- peptidase, as well as glomerular filtration. ...
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Effect of astragalus injection on renal tubular epithelial transdifferentiation in type 2 diabetic mice
... male KKAy mice (9–11 weeks of age) weighing 25–28 g were used in the current ...J mice (9–11 weeks of age) weighing 23–25 g were used as age-matched ...All mice were purchased from the Animal ...
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Eicosapentaenoic acid ethyl ester improves endothelial dysfunction in type 2 diabetic mice
... Male KKAy mice were fed a high-fat (HF) diet for 8 weeks to induce diabetes, after which they were divided into two ...diabetic mice, total cholesterol levels were significantly ...diabetic ...
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Original Article Therapeutic effects of emodin in type 2 diabetes mellitus in KKAy mouse model
... Abstract: Emodin has been reported to reverse hyperglycemia, insulin resistance, and other symptoms associated with metabolic diseases in the previous studies. However, the underlying mechanisms remain poorly understood. ...
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Oral kanglaite injection (KLTI) attenuates the lung cancer-promoting effect of high-fat diet (HFD)-induced obesity
... KLTI, mice were fed either the SRC or HFD and were orally administered KLTI once daily for 20 ...SRC-fed mice (BW 31.4 ± 2.2 g in SRC-fed C57BL/6J mice vs ...C57BL/6J mice (P > 0.05) and ...
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Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser1177/Thr497 of endothelial nitric oxide synthase in diabetic mice
... in KKAy mice treated with vehicle, candesartan cilexetil, or azilsartan as compared to C57BL/ 6 J, indicating no difference in uric acid metabolism be- tween two ...ApoE−/− mice via the PPARγ pathway ...
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Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice
... in mice with developing hypoxia-induced ...in mice exposed to chronic ...hypoxic mice may be related to the increase in circulating progenitor cells dur- ing hypoxia, as suggested by previous ...
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1.8 Themes
... Crooks reveals that it is the favourite dream of the itinerant ranch hands: Crooks reveals that it is the favourite dream of the itinerant ranch hands: 'Seems like ever' guy got land[r] ...
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Transgenic mice over expressing carbonic anhydrase I showed aggravated joint inflammation and tissue destruction
... transgenic mice that over-expressed CA1 were markedly susceptible to collagen treatment and showed a high incidence and serious symptoms of arth- ...CA1-Tg mice. In contrast to CA1-Tg mice, clinical ...
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Insulin sensitivity : modulation by the brain
... the mice to develop obesity in combination with partial, rather than complete, insulin resistance, and, as a result, effects of central insulin antagonism in these diet-induced obese mice could still be ...
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<p>Long-term icariin treatment ameliorates cognitive deficits via CD4<sup>+</sup> T cell-mediated immuno-inflammatory responses in APP/PS1 mice</p>
... transgenic mice, 25 presents substantial, age-related neuron loss in the pyramidal layer of the hippocampus, which has been widely used to explore underlying AD ...
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Hyaluronan digestion controls DC migration from the skin
... expression exhibited extensive HA degradation, yet displayed no evidence of spontaneous inflammation. Further, HYAL1 expression activated migration and promoted loss of DCs from the skin. We subsequently determined that ...
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Runx1 and Runx2 cooperate during sternal morphogenesis
... f/f mice and a 1(II) DKO mice did not show any abnormal sternal morphogenesis or chondrocyte ...DKO mice; however, commitment to the chondrocyte lineage, which follows mesenchymal condensation, was ...
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1.9 Conflict Curlys Wife
... anybody, I get awful lonely.’’ This shows us that she has no female friends or any friends at all. She has no one to share her problems/thoughts with and this could make her feel isol[r] ...
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Vulnerability or resilience of motopsin knockout mice to maternal separation stress depending on adulthood behaviors
... Subject mice were randomly separated into two groups at postnatal day (P) ...(3–5 mice/cage) of same sex ...MS mice were individually housed for 2 weeks before behav- ioral tests were started at 14 ...
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Neuroendocrine immunomodulation network dysfunction in SAMP8 mice and PrP-hAβPPswe/PS1 ΔE9 mice: potential mechanism underlying cognitive impairment
... SAMP8 mice, ACTH and GnRH correlated with that of APP/PS1 ...APP/PS1 mice, while IL-2, IL-5, IL-23, MCP-1, MIP-1β, RANTES, and eotaxin only correlated with the cognitive function of SAMP8 mice, and ...
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