KL-6
Ageing and long-term smoking affects KL-6 levels in the lung, induced sputum and plasma
... of KL-6 in the lung tissue was investigated in 7 non-smoking controls, 7 smokers and 14 patients with COPD (Table ...[15,18], KL-6 could be detected in the alveolar type II cells and ...
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MUC1 gene polymorphisms are associated with serum KL-6 levels and pulmonary dysfunction in pulmonary alveolar proteinosis
... cohort), KL-6 levels were higher in serum of healthy controls and sarcoidosis pa- tients carrying the G allele, with G homozygotes having the highest levels, A homozygotes the lowest, and het- erozygotes ...
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Rheumatoid Arthritis with High Serum KL 6 Complicating Malignant Tumor: Two Case Reports
... Because KL-6 gradually became elevated and too high (1250 U/mL) 5 months after KL-6 elevation, we re-examined her by ...and KL-6 entered the normal range (263 U/mL) 5 months ...
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Original Article Association between serum Krebs von den Lungen-6 (KL-6), Carcinoma antigen 15-3 (CA15-3), and connective tissue disease-related interstitial pneumonia (CTD-ILD)
... There are some shortcomings to this study. First, 156 patients with CTD-ILD and 43 pa- tients with simple CTD were included in the study. Although these numbers are sufficient to investigate the relationship between ...
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Original Article SP-D, KL-6, and HTI-56 levels in children with mycoplasma pneumoniae pneumonia
... SP-D, KL-6 and HTI-56 in infected BALF compared with uninfected BALF is thought to be due at least partly to destruc- tion of alveolar epithelial cell membranes and release into the ...SP-D, ...
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The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D
... Methods: Serum levels of napsin A were measured in 20 patients with IPF, 34 patients with lung primary adenocarcinoma, 12 patients with kidney diseases, and 20 healthy volunteers. Surfactant protein (SP)-A, SP-D, and ...
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KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome
... ELF KL-6 within 3 days after the diagnosis appeared to correlate with poor prog- nosis in ARDS ...results: KL-6 levels in ELF were significantly elevated in the nonsurvivors on days 0 to 3 ...
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Serum KL 6 levels reflect the severity of interstitial lung disease associated with connective tissue disease
... evaluating KL-6 and included the lar- gest sample size of CTD-ILD ...of KL-6 to be used in rheumatology clinics for the detection and follow-up of ILD patients with ...serum KL-6 ...
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Original Article Clinical value of serum KL-6 for lung diseases in patients with polymyositis and dermatomyositis
... els, the proportion of forced expiratory volume in one second to the predicted value (FEV1%), the proportion of forced vital capacity to the predicted value (FVC%), FEV1/FVC, the propor- tion of residual volume to the ...
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Plasma levels of surfactant protein D and KL-6 for evaluation of lung injury in critically ill mechanically ventilated patients
... from direct causes (e.g., pneumonia), it may be that plasma levels of pulmonary proteins are also different patients or pneumonia patients with ALI/ARDS. While we performed multivariate analysis controlling for this ...
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Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease
... in 6 patients. Figure 1 shows the absolute serum KL-6 levels at the baseline according to the presence of preexisting pulmonary ...serum KL-6 levels at the baseline showed no ...
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Serum KL-6 is a predictor of outcome in pulmonary alveolar proteinosis
... Continuous variables were evaluated for a normal distri- bution with the Kolmogorov-Smirnov test. Parametric data are presented as mean ± SE and nonparametric data are presented as median and interquartile range (IQR). ...
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KL-6, a Human MUC1 Mucin, as a prognostic marker for diffuse alveolar hemorrhage syndrome
... of KL-6 as a prognos- tic marker in DAH has not been shown. KL-6 is likely to increase in various types of lung injury resulting in epi- thelial damage, and may not be unique for ...of ...
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Seasonal variation of serum KL-6 concentrations is greater in patients with hypersensitivity pneumonitis
... serum KL-6 concentrations among ILD were tested by the Kruskal-Wallis ...serum KL-6 concentrations between two groups were evaluated by the two-tailed Mann–Whitney ...Serum KL-6 ...
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Serum concentrations of Krebs von den Lungen-6, surfactant protein D, and matrix metalloproteinase-2 as diagnostic biomarkers in patients with asbestosis and silicosis: a case–control study
... Lungen 6 (KL-6), surfactant protein D (SP-D), and matrix metalloproteinases (MMPs) are potential biomarkers for diagnosing and monitoring progression of various fibrotic lung ...
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Prognostic value of immunohistochemical surfactant protein A expression in regenerative/hyperplastic alveolar epithelial cells in idiopathic interstitial pneumonias
... and KL-6, were reported to be use- ful biologic markers for predicting prognosis of interstitial pneumonia (IP) ...[8-14]. KL-6 is expressed on epithelial cells, being a mucin-like ...or ...
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Nintedanib allows retreatment with atezolizumab of combined non-small cell lung cancer/idiopathic pulmonary fibrosis after atezolizumab-induced pneumonitis: a case report
... The patient underwent first-line treatment with carbo- platin and nab-paclitaxel from May 201X. After 4 cycles, disease progression was recognized. Therefore, second- line chemotherapy of pembrolizumab was administered. ...
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Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management
... and KL-6 serum concentrations showed that both markers were elevated in patients with SSc-associated ILD compared with healthy controls, with SP-D being more sensitive and KL-6 more specifi c ...
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Cefditoren versus levofloxacin in patients with exacerbations of chronic bronchitis: serum inflammatory biomarkers, clinical efficacy, and microbiological eradication
... human KL-6 enzyme-linked immunosorbent assay kit can be used for in vitro quantitative determination of human KL-6 concentrations in serum, plasma, and other biological ...for ...
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Preoperative Serum Krebs Von Den Lungen 6 and Surfactant Protein D Levels in Non Small Cell Lung Cancer Patients with Interstitial Pneumonia
... serum KL-6 and SP-D levels was ...serum KL-6 and SP-D levels in NSCLC patients with ...serum KL-6 level was poor, whereas serum SP-D level was not related to pa- tients’ ...serum ...
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