knock out mice
Cognitive Function in BK Channel Knock-Out Mice
... homozygous knock-out animals spent significantly more time in the target quadrant than heterozygous animals but did not differ from wild-type animals, showing that once the task had been acquired, ...
76
IFN gamma potentiates atherosclerosis in ApoE knock out mice
... of mice with a targeted disruption of IFN- g (21) or the IFN- g receptor ...these mice display a profound impairment of their immune response to several intracellular pathogens (6, ...0) mice has ...
11
Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-β knock-out mice
... IFN-β knock out mice do not have any fail- ing mounting a T H 1 response, measured by IFN-γ ...IFN-β knock out mice had more severe and chronic symptoms than their WT littermates ...
12
Prevention of elastase-induced emphysema in placenta growth factor knock-out mice
... PlGF expression increases significantly in early gestation, peaks at around 26-30 weeks, and decreased as term approaches [29]. However, the biological function of PlGF after gestation and in adulthood remains unclear. ...
10
Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice
... Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP). Kainate receptor (KAR) is a subfamily of ionotropic glutamate receptors (iGluR) that acts mainly as a neuromodulator of synaptic ...
11
LDL receptor knock-out mice show impaired spatial cognition with hippocampal vulnerability to apoptosis and deficits in synapses
... ) mice (n = 10) and C57BL/6 J littermates (n = 14) were pur- chased from the Model Animal Resource Information Platform of Nanjing ...−/− mice (stock #002207, strain name ...produce mice that lack ...
11
Ca2+-signaling in airway smooth muscle cells is altered in T-bet knock-out mice
... tial resolution [29]. With this approach, we were able to combine the advantages of a complex tissue culture sys- tem preserving many of the alterations observed in vivo with the ability to observe single cell ...
11
The role of interleukin-12 in the heavy metal-elicited immunomodulation: relevance of various evaluation methods
... gene knock-out mice have been proven to be useful for evaluat- ing the regulation of immunocompetent cells in response to infection or following exposure to heavy ...
14
The Preservation of in vivo Phosphorylated and Activated Uncoupling Protein 3 (UCP3) in Isolated Skeletal Muscle Mitochondria following Administration of 3,4 Methylenedioxymethamphetamine (MDMA aka Ecstasy) to Rats/Mice
... UCP1 knock-out mice states that “UCP3 is not innately uncoupling, that it cannot be induced to act as an uncoupler by either fatty acids or by endogenous reactive oxygen species, and that effects of ...
40
Original Article NLRP3 inflammasome is essential for the development of chronic obstructive pulmonary disease
... figure out the above question, NLRP3 knock out mice were adapted, the NLRP3 knock out mice were treated as same dose and duration of COPD modeling ...COPD mice ...
8
P-glycoprotein at the blood-brain barrier: kinetic modeling of 11C-desmethylloperamide in mice using a 18F-FDG μPET scan to determine the input function
... WT mice pretreated with cyclosporine were displayed in Figure ...wild-type mice without pre- treatment of cyclosporine, the average brain SUVs were ...KO mice SUVs were sig- nificantly higher ...
9
Absence of mitochondrial uncoupling protein 3: Effect on thymus and spleen in the fed and fasted mice
... UCP3 is predominantly found associated with skeletal muscle mitochondria [1-3], however it is still not clear what UCP3 actually catalyzes in vivo. One constant is the physiological observation that increased UCP3 ...
36
Synergic interaction between amyloid precursor protein and neural cell adhesion molecule promotes neurite outgrowth
... Alzheimer's disease (AD) is one of the most common neurodegenerative diseases worldwide. The main features of AD are the pathological changes of density and distribution of intracellular neurofibrillary tangles (NFT) and ...
8
Absence of Mitochondrial Uncoupling Protein 1 Affects Apoptosis in Thymocytes, Thymocyte/T Cell profile and Peripheral T Cell Number
... mice were isolated and the cells were stained for with FITC-conjugated anti-CD4, R- PE-conjugated anti-CD8 (both from BD Biosciences) and analyzed on the FACS Cyan. Representative primary data for spleen cell from ...
38
Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1
... C57BL6 mice were obtained from Charles River (Boston, MA, USA) and Taconic (Albany, NY, ...APP knock out and APLP2 knock out mice were obtained form Jackson Labs (Bar Harbor, ME, ...
14
Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice
... (-/-) mice (in contrast to humans, rodents have two genes for P-gp, called Mdr1a and Mdr1b), are healthy and fertile under normal condi- tions ...[7,8]. Mice that lack Mrp1 and both Mdr1a/1b genes, from ...
8
New and novel uses for paracetamol
... Time-profile to the effect of 300mg/kg paracetamol on the basal body temperature in COX-1 & COX-2 genes knock-out mice.. COX-1 gene knockout mice.[r] ...
36
Chronic Cerebral Ischemia-Induced Memory Impairment After Inhibition of BDNF by Interleukin-1 Signaling Pathway
... type mice was not affected after ...IL-1R knock-out ...type mice) (P ...of mice. IL-1β and BDNF in hippocampuses of the IL-1R knock-out mice return to normal levels ...
5
Roles of Semaphorin 6B and Plexin A2 in Lamina Restricted Projection of Hippocampal Mossy Fibers
... Sema6B-deficient mice several mossy fibers aberrantly project to the stratum radiatum and the stratum ...double knock-out mice, indicating that Sema6A and Sema6B function additively to ...
12
Hearing impairments caused by genetic and environmental factors
... c-Ret knock-in mice and Endothelin receptor B (Ednrb) knock-out mice, it was found that syndromic hearing losses involved postnatal neurodegeneration of SGNs caused by impairments of ...
6