Knock-out mice
Dendritic Spines in FMR1 Knock-Out Mice
... FMR1 knock-out mice do not have spines with abnormal length, density, or motility, despite the abnormalities in spine length and density in the intact ...
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Cognitive Function in BK Channel Knock-Out Mice
... homozygous knock-out animals spent significantly more time in the target quadrant than heterozygous animals but did not differ from wild-type animals, showing that once the task had been acquired, ...
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IFN gamma potentiates atherosclerosis in ApoE knock out mice
... 0 mice exhibited a significant increase in a distinct population of lipoprotein particles that are rich in apoA-IV, phospholipid, and free ...compound knock-out mice contributed to the ...
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Cannabinoid Withdrawal Syndrome Is Reduced in Pre-Proenkephalin Knock-Out Mice
... receptor antagonists blocked some effects of THC on the reward system (Gardner and Lowinson, 1991) and produced withdrawal syndrome in THC-dependent rodents (Kaymakcalan et al., 1977). Conversely, cannabinoid agonists ...
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Efficient generation of knock out mice by the CRISPR/Cas9 system with two guide RNAs
... CRISPR/Cas9, knock out mice, two guide RNA 緒 言 医学・薬学・生命科学研究において，古くから実験 動物として用いられ，また，現在最も利用されている モデル生物はマウスである．これには，マウスは短期 間で性成熟するため（雄 : 6 週間，雌 : 4 週間）その ライフサイクルが比較的短いこと，また，多産で飼育 ...
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Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-β knock-out mice
... β knock out mice vaccinated with CpG-ODN which was in agreement with earlier ...non-treated mice, at least under the con- ditions used in this study, the results also suggest that CpG is ...
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Improved efficacy of fluoxetine in increasing hippocampal 5-hydroxytryptamine outflow in 5-HT 1B receptor knock-out mice
... knock-out mice. This latter change was correlated with a 5- HT hyperinnervation in this brain region of mutants: this regional selectivity of 5-HT hyperinnervation may partly explain our ...
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Enhanced osteoclast development in collagen induced arthritis in interferon γ receptor knock out mice as related to increased splenic CD11b+myelopoiesis
... TRAF6-deficient mice reportedly do produce osteoclasts within their bone, and the numbers of TRAP + cells per square millimetre of tissue area are comparable in wild-type and knock-out mice ...
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Prevention of elastase-induced emphysema in placenta growth factor knock-out mice
... Based on the previous in vitro study, the chronic activation of epithelial cells with PlGF and other cytokines induces cell death and apoptosis, which can be abolished by a VEGF R1 inhibitor [14]. In this study, ...
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Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice
... In this study, we performed whole-cell patch-clamp recordings from layer II/III pyramidal neurons in the insular cortex of Fmr1 KO mice. We found that KARs mediated currents were reduced in Fmr1 KO mice. ...
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Ca2+-signaling in airway smooth muscle cells is altered in T-bet knock-out mice
... To measure baseline airway tone (BAT) we used a relaxa- tion solution consisting of 10 -3 M β-escin and 10 -7 M ATP in phosphate-buffered saline without calcium containing 0.02 % EDTA to permeabilize the cell membrane in ...
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Increased sensitivity to inflammatory pain induced by subcutaneous formalin injection in serine rasemase knock-out mice.
... mutant mice lacking ...WT mice, 2) the SR-KO mice showed increased sensitivity to inflammatory pain induced by formalin injected subcutaneously, 3) the expression levels of the c-Fos and p-ERK ...
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Histological analysis of the impact of the lack interferon receptors alpha and beta in the knock- out mice infected with cytomegalovirus
... Material and methods: The study was performed on mice of C57/B6 and IFNαβR KO strains. Two animals of each strain were used, one as a control, that received only a virus-free medium and another infected with a ...
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LDL receptor knock-out mice show impaired spatial cognition with hippocampal vulnerability to apoptosis and deficits in synapses
... −/− mice displayed a decrease in synapse density/number, as shown by the reduced SIBPs in hippocampal DG other than CA1 regions and the decreased expression of ...−/− mice revealed mul- tiple synaptic ...
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Bitter melon (Momordica charantia) attenuates atherosclerosis in apo-E knock-out mice possibly through reducing triglyceride and anti-inflammation
... find out the reduction of pro-inflammatory cytokines and cellular adhesion molecules, which play an important role in inflammation of cardiovascular disease, when treated with bitter ...
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Knock In Knock Out Option Examples
... if, knock knock out examples, traders who are using these types, or all levels will lose in plants to the pm of the ...a knock examples of the observable property must be worthless, in or ...
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Knock Out Blackjack
... This is the optimal method of play withknowl- edge of only the cards the player is holding and the dealer's upcard (and perhaps information about the dealer's down- card, for example, wh[r] ...
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Effect of hyperlipidemia on the expression of circadian genes in apolipoprotein E knock-out atherosclerotic mice
... postpartum) mice were purchased from Beijing Labora- tory Animal Research Center (Beijing, ...ApoE-/- mice were randomly divided into two groups: half of these mice (n = 18) were fed with regular ...
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Suggested Templates for European Knock-Out/ Knock-In Options and Binary Options
... At the request of various market participants, the Committee convened a special study group to produce foreign exchange exotic option templates that are designed to reflect current market practice. The first template, on ...
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The American Knock-Out Put Option
... strike price K . In practice, the option holder may choose to sell his option at any time during the term of the contract, and thus one may view his payoff as the price he receives upon selling. We choose � = 13 since ...
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