Kruppel-like factor 2 (KLF2)
Statin induced Kruppel like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses
... transcription factor kruppel-like factor 2 (KLF2) is required for the quiescent and migratory properties of naive T ...upregulate KLF2 expression in endothelial cells, and ...
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Integration of flow dependent endothelial phenotypes by Kruppel like factor 2
... transcription factor Kruppel-like factor 2 (KLF2) is selectively induced in endothelial cells exposed to a biomechanical stimu- lus characteristic of atheroprotected regions of ...
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Kruppel-like factor 2 suppresses mammary carcinoma growth by regulating retinoic acid signaling
... transcription factor Kruppel-like factor 2 (KLF2) displays anticarcinogenic activities but the mechanism that underlies this activity is ...that KLF2 is markedly ...
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<p>Laquinimod Protects Against TNF-α-Induced Attachment of Monocytes to Human Aortic Endothelial Cells (HAECs) by Increasing the Expression of KLF2</p>
... key factor in fl uencing stroke pathogenesis, and inhibition of the in fl ammatory response has been sug- gested as a treatment ...necrosis factor- α (TNF- α ) is secreted by monocyte-macrophages and plays a ...
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Endothelial Kruppel like factor 4 protects against atherothrombosis in mice
... In the early 1970s, the pioneering efforts of Jaffe and colleagues describing EC isolation ushered in the modern era of vascular biol- ogy (6). Studies over the ensuing 3 decades by numerous groups led to the ...
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Kruppel like factor 15 is critical for vascular inflammation
... the Kruppel-like family of factors as important regulators of inflammation ...(Figures 2 and ...as KLF2 and KLF4, are strongly expressed in endothelial and hematopoi- etic lineages, perhaps ...
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Progression of diet induced nonalcoholic steatohepatitis is accompanied by increased expression of kruppel like factor 10 in mice
... Figure 1 Changes in KLF10 and other associated gene expression in diet induced NASH. C57BL/6 mice were fed with high fat, sucrose diet (HFSD) and sacrificed at 12, 24, or 48 weeks after the feeding. Mice that were given ...
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Tumor-suppressive role of Kruppel-like factor 4 (KLF-4) in colorectal cancer.
... To correlate KLF-4 expression with the clinicopathological characteristics of the CRC patients, we then analyzed the heterogeneity in gender, age, the location, stages (T or N stage), differentiation invasion, and ...
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Kruppel like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis
... Cell culture and cell-based assay. NRVMs (isolated from 2-day-old Sprague Dawley rats) and HEK293 cells (ATCC CRL-1573) were cul- tured as described previously (24). Expression plasmids (KLF4, ERRα, ERRγ, PGC-1α, ...
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Original Article Association of Kruppel-like factor 4 expression with the prognosis of esophageal squamous cell carcinoma patients
... Abstract: Objective: To investigate the association of Kruppel-like factor 4 (KLF4) expressions with the prognosis of esophageal squamous cell carcinoma (SCC) patients. Methods: Ninety-eight cases of ...
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Berberine regulates the protein expression of multiple tumorigenesis-related genes in hepatocellular carcinoma cell lines
... including Kruppel‑like factor 6 (KLF6), activating transcription factor 3 (ATF3) and p21, while down‑regulating the expression of selected oncogenes, including E2F transcription factor ...
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Original Article Increased expression of Zinc finger protein 267 in non-alcoholic fatty liver disease
... The Kruppel-like transcription factor (KLF) family is involved in the regulation of diverse aspects of cellular development, differentiation, growth, and activation ...
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Kruppel like factor 5 is required for perinatal lung morphogenesis and function
... mRNA microarray studies of the lungs from Klf5 Δ / Δ mice demonstrated that KLF5 was required for the normal expression of genes regulating surfactant phospholipid homeostasis, including Abca3, Abca4, Aytl2, Liph, Srebf1 ...
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Nuclear Klf4 accumulation is associated with cetuximab drug resistance and predicts poor prognosis of nasopharyngeal carcinoma
... Klf4: Kruppel-like factor 4; cKlf4: cytoplasm Kruppel-like factor 4; nKlf4: nuclear Kruppel-like factor 4; EGFR: epithelial growth factor receptor; ...
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Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15
... growth factor (CTGF)); and (2) that ACE inhibition would reverse LVH and fibrosis in CKD and restore cardiac KLF15 levels and corresponding changes in transcriptional regulators and hypertrophic and ...
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Krüppel-like family of transcription factors: an emerging new frontier in fat biology
... mammals, excess fat is stored in adipose tissue and, when needed, is able to provide energy. As a complex, multi-factorial trait driven by natural selection based upon food availability, fat storage is highly regulated ...
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PubMedCentral-PMC4739742.pdf
... The role of KLF1 in fetal-to-adult globin gene switching is currently studied in human sys- tems, because reactivation of γ -globin has therapeutic potential for the β -hemoglobinopathies. Naturally occurring ...
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Targeting insulin-like growth factor axis in hepatocellular carcinoma
... IGF-1R monoclonal antibodies in HCC IMC-A12 was studied as a single agent in patients with advanced HCC as a front line systemic therapy. This study unfortunately was terminated due to futility. The pre-planned primary ...
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Kruppel-like factor4 regulates PRDM1 expression through binding to an autoimmune risk allele
... regulatory factor 5 (IRF5) (10), signal transducer and activator of transcription 4 (STAT4) (11, 12), interleukin-1 receptor-associated kinase 1 (IRAK1) (13, 14), tumor necrosis factor α–induced protein 3 ...
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Pdm and Castor close successive temporal identity windows in the NB3 1 lineage
... Fasciclin 2 (FasII) 1:100, mouse FasIII 1:5 (Developmental Studies Hybridoma Bank, University of Iowa); rabbit Hb 1:200 (this work); guinea pig Kr 1:500 [East Asian Distribution Center for Segmentation Antibodies ...
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