Kruppel-like factor 4 (KLF4)
Original Article Association of Kruppel-like factor 4 expression with the prognosis of esophageal squamous cell carcinoma patients
... Kruppel-like factor 4 (KLF4), a zinc-finger-type transcriptional factor that is widely expressed in many human tissues, plays an important role in regulating cell proliferation, ...
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Angiotensin II Downregulates MicroRNA-145 to Regulate Kruppel-like Factor 4 and Myocardin Expression in Human Coronary Arterial Smooth Muscle Cells under High Glucose Conditions
... (including Kruppel-like factor 4 [Klf4] and myocardin) in VSMCs under hyperglycemic ...increased Klf4 and decreased myocardin expression under conditions of high ...decreased ...
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Endothelial Kruppel like factor 4 protects against atherothrombosis in mice
... implicate Kruppel-like factors (KLFs) as important regulators of vascular homeostasis, the in vivo role of these factors in endothelial biology remains ...endothelial KLF4 is an essential determinant ...
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Kruppel like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis
... of KLF4 in cardiomyocyte/mitochon- drial biology that remain incompletely understood and will require further ...the KLF4-null hearts, cardiac function was ...the KLF4-defi- cient state at baseline ...
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Tumor-suppressive role of Kruppel-like factor 4 (KLF-4) in colorectal cancer.
... In total, 68 CRC specimens were obtained from CRC patients subjected to radical resection and who received 5-FU-based chemotherapy after surgery, with complete clinicopathological data recorded for each specimen. Patient ...
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Progression of diet induced nonalcoholic steatohepatitis is accompanied by increased expression of kruppel like factor 10 in mice
... Figure 4 Decreased KLF10 mRNA expression and improved NASH upon UDCA administration with HFSD. C57BL/6 mice were fed with either standard diet (SD) or high fat, sucrose diet (HFSD) for 24 weeks upon which mice on ...
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Kruppel like factor 15 is critical for vascular inflammation
... 2, 4, 5, and 15) (35). Consequently, competition between KLF1/2/4/5/15 and p53 for p300 may provide a mechanism by which these KLFs can regulate major cellular processes such as survival and adaptation to ...
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Integration of flow dependent endothelial phenotypes by Kruppel like factor 2
... Endothelial KLF2 expression is selectively induced by a distinct type of flow in vitro and is dependent on blood flow in vivo. To identify critical tran- scriptional regulators of endothelial mechano-activated programs, ...
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Network analysis of KLF5 targets showing the potential oncogenic role of SNHG12 in colorectal cancer
... Kruppel-like factor 5 (KLF5) is one of the 17 known members of the Kruppel-like factor subfamily of zinc fin- ger proteins ...
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Kruppel-like factor 2 suppresses mammary carcinoma growth by regulating retinoic acid signaling
... Figure 4: KLF2 directly induces the expression of CRABP2 and RARγ, and RARγ directly regulates KLF2 transcription. A.-C. ChIP assays were carried out using MDA-MB-231 cells stably over-expressing GFP or KLF2. ...
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Statin induced Kruppel like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses
... to study the influence of statins on human T cell functional responses when KLF2 expression was blocked. Reliable RNA knockdown in primary mouse T cells has proven very difficult to accomplish, and mice with T ...
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Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15
... vitro, KLF4 expression is in- duced with hypertrophic stimulation with either Ang II, endothelin-1 and phenylephrine in neonatal rat ventricu- lar myocytes ...cardiac KLF4 gene expression [34]. KLF4 ...
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Original Article Increased expression of Zinc finger protein 267 in non-alcoholic fatty liver disease
... The Kruppel-like transcription factor (KLF) family is involved in the regulation of diverse aspects of cellular development, differentiation, growth, and activation ...
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Reprogramming of the chick retinal pigmented epithelium after retinal injury
... RT-qPCR was performed using a 20 μl mixture containing 5 μl (4 ng) SPIA cDNA, 10 μl 2× SYBR Green/Fluorescein qPCR Master Mix (SABiosciences, Qiagen, MD, USA), and a 500 nM final concentration of the primers. ...
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Nuclear Klf4 accumulation is associated with cetuximab drug resistance and predicts poor prognosis of nasopharyngeal carcinoma
... at 4 °C with the following primary antibodies: (dilution 1:200, abcam, ...proteins. KLF4 immu- noreactivity was examined using a mouse polyclonal ...
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Kruppel-like factor4 regulates PRDM1 expression through binding to an autoimmune risk allele
... For KLF4, 10 μg of anti-KLF4 goat pAbs (AF3640) or control antibodies (AB-108-C) (both purchased from R&D Systems) was incubated with 100 μl of protein-G magnetic beads (Novex, Thermo Fisher Scientific) ...
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Krüppel like factor 4 regulates macrophage polarization
... of KLF4 provides a molecular mechanism to not only induce the M2 phenotype but also inhibit the M1 ...of KLF4’s inhibition of proinflammatory tar- gets is highlighted by gain- and loss-of-function studies ...
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Krüppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation
... Significant 4-fold increase in iNOS expression with 500 ng/ml LPS dose after 12 hours of stimulation was observed which was found significant with respect to control (p < ...about 4-fold with respect to ...
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Polo-Like Kinase 1 phosphorylates and stabilizes KLF4 to promote tumorigenesis in nasopharyngeal carcinoma
... of KLF4 can be regulated at both the transcriptional and post-transcriptional levels ...of KLF4 and methylation of histones modulates its activity in cancer ...regulate KLF4 activity by ...
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Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation
... blocking solution for 1 hour at 25°C. The cells were then incubated with rabbit anti-Klf4 (1:250; Millipore) overnight at 4°C. Anti-rabbit Alexa fluor 594 secondary antibody (1:1,000; Vector Laboratories) ...
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