Kupffer cell
Th2-Associated Alternative Kupffer Cell Activation Promotes Liver Fibrosis without Inducing Local Inflammation
... that Kupffer cell phenotype was characterized only by means of mRNA ...such Kupffer cell activation markers and cytokines at protein and protein activity ...alternatively-activated ...
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Effects of zinc oxide nanoparticles on Kupffer cell phagosomal motility, bacterial clearance, and liver function
... in Kupffer cell phagosomal motion, and later cause hepatocellular ...from Kupffer cells may cause adverse effects on the hepa- tocytes over time, as indicated by histological evidence of liver ...
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Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet derived growth factor receptors
... Hepatic lipocytes appear to be central to the pathogenesis of hepatic fibrosis, undergoing activation during inflammation to a matrix-producing, proliferative cell type. We have studied the activation process in ...
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The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors.
... of Kupffer cells by gadolinium chloride ...While Kupffer cell depletion nearly eliminated adenovirus-induced TNF release, it resulted in a more robust IL-6 ...the Kupffer cells, suggesting ...
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SiO<sub>2</sub> nanoparticle-induced impairment of mitochondrial energy metabolism in hepatocytes directly and through a Kupffer cell-mediated pathway in vitro
... antibodies, Cell Signaling Technology, Danvers, MA, USA) overnight at 4 ° C, washed with TBST, and incubated with a horseradish peroxidase-conjugated anti-rabbit IgG secondary antibody for one hour at 37 ° ...
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Tumor-derived nanovesicles promote lung distribution of the therapeutic nanovector through repression of Kupffer cell-mediated phagocytosis
... [18]. Kupffer cells represent 80–90% of all tissue macrophages in the body are involved in the capture and clearance of foreign materials [19, ...by Kupffer cells, leading to the accumulation of ...
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Kupffer cell-mediated hepatic injury induced by silica nanoparticles in vitro and in vivo
... nonparenchymal cell enriched ...nonparenchymal cell fraction was layered onto the Percoll ...nonparenchymal cell fraction into distinct zones in the ...The cell con- centration was adjusted to ...
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Huangqi decoction inhibits apoptosis and fibrosis, but promotes Kupffer cell activation in dimethylnitrosamine induced rat liver fibrosis
... of cell types and mediators to encapsulate an in- ...from Kupffer cells (KCs), angiogenesis, and hepatic stellate cell (HSC) activation, interact with each other, leading to collagen deposition ...
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Identification of Adenovirus Serotype 5 Hexon Regions That Interact with Scavenger Receptors
... Kupffer cell depletion does not affect transduction by vectors after HVR-targeted ...Eliminating Kupffer cells by predosing increases liver transduction by unmodified Ad5 10- to 40-fold ...liver ...
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Neutrophil derived S100 calcium binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes
... of Kupffer cells in the liver and found that diabetes was associated with a significant increase in the number of Kupffer cells (Figure ...assessed Kupffer cell–specific expression of IL-6, a ...
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Cell derived anaphylatoxins as key mediators of antibody dependent type II autoimmunity in mice
... both Kupffer cell and SEC FcγR, C5, and C5aR ...nonparenchymal cell fraction was centrifuged at 800 g for 10 minutes and immediately taken for SEC and Kupffer cell isolation and ...
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Effect of bone marrow transplantation on enzyme levels and clinical course in the neurologically affected twitcher mouse
... Our studies have shown that the increased enzyme activity in liver tissue of transplanted twitcher mice is not due only to Kupffer cell replacement, but also to uptake of galactosylceram[r] ...
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Oxidized or acetylated low density lipoproteins are rapidly cleared by the liver in mice with disruption of the scavenger receptor class A type I/II gene
... and Kupffer cells from knockout and control mice, and compared the uptake of acetyl LDL and oxidized LDL by these ...nonparenchymal cell prepa- rations was assessed by staining for peroxidase activity, and ...
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Infection of Primary Cultures of Human Kupffer Cells by Dengue Virus: No Viral Progeny Synthesis, but Cytokine Production Is Evident
... hepatocytes, Kupffer cell hyperplasia, and cen- trolobular and midzonal necrosis ...and Kupffer cells (1, 3, 9, ...human Kupffer cells, the macrophages residing in the liver, have never been ...
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Short Term International Study For Teachers As A Form of Experiential Learning: A Case Study of American Educators in Turkey
... vitro. Kupffer cell activation was also significantly decreased by SsnB as evidenced by reduction in CD68 and monocyte chemoattractant protein 1 (MCP1) mRNA and protein levels with associated inhibition of ...
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Macrophages eliminate circulating tumor cells after monoclonal antibody therapy
... tumor cell elimination or the effector cells that are ...tumor cell opsonization ...mAbs, Kupffer cells sampled tumor cells; however, this sampling was not sufficient for ...by Kupffer cells ...
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High hepatic macrophage activation and low liver function in stable Wilson patients - a Danish cross-sectional study
... inflammatory Kupffer cell activation may be involved in the loss of liver function and that measurement of the sCD163 results in informa- tion that is not obtained by ...
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Differential Activation of Innate Immune Responses by Adenovirus and Adeno-Associated Virus Vectors
... a Kupffer cell-dependent activation of innate im- mune responses following AAV vector ...of Kupffer cells in the first line of defense against invading patho- gens in the liver ...
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Zillies, Jan (2007): Gelatin Nanoparticles for Targeted Oligonucleotide Delivery to Kupffer Cells - Analytics, Formulation Development, Practical Application. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... in Kupffer cells playing a central role in the inflammatory cascade finally causing loss of liver ...selective Kupffer cell targeting of an NF-κB inhibiting decoy oligonucleotide was proposed as ...
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Histopathological and Enzymatic Changes in Liver of Mice Treated with Tricyclazole
... Widespread application of toxins can cause teratogenic effects on various growth- related phenomena, which has raised concerns about the potential damages that pesticides can inflict on human health and the ecosystem ...
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