L-glutaminase
PRODUCTION AND CHARACTERIZATION OF L GLUTAMINASE BY BACILLUS SP
... ABSTRACT: L-Glutaminase ...of L-glutamine resulting in the production of L-glutamic acid and ...ammonia. L-Glutaminase is gaining marked importance due to its application ...
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Optimization of L glutaminase (EC 3 5 1 2) enzyme production by Streptomyces griseus using rice bran through statistical designs
... improving L- Glutaminase production using the software Design-Expert Version ...maximum L-Glutaminase activities (IU/ml) were taken as responses ...
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Statistical Optimization based Production of L-Glutaminase (EC.3.5.1.2) by Serratia marcescens under submerged Fermentation
... Glycine, L –Ascorbic acid, L –Glutamine, Cysteine, Alanine) at 10 g/L,effect of different additional minerals (Zinc sulphate, Mercuric sulphate, Manganous sulphate, Copper sulphate, Ferrous sulphate, ...
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L-Glutaminase Production by a Terrestrial Pseudomonas Species Isolated from Nigerian Soil
... on l- glutaminase production by Pseudomonas species ALG3 is shown in fig ...maximum glutaminase yield ...and glutaminase production. The highest l-glutaminase production was ...
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INVESTIGATION ON THE PRODUCTION OF L-GLUTAMINASE FROM PSEUDOMONAS STUTZERI STRAIN UNDER SOLID STATE FERMENTATION USING VARIOUS AGRO RESIDUES
... of L-glutamine resulting in the production of L-glutamic acid and ...ammonia. L-Glutaminases are ubiquitous in the biological world 1-2 and organisms ranging from bacteria to human beings have the ...
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Enhancement of the production of L glutaminase, an anticancer enzyme, from Aeromonas veronii by adaptive and induced mutation techniques
... Statistical designs lead to improved yields, less laborious and more precise in their results than the experiments optimized with one factor at a time, where the interactions among the factors are also ignored [13]. The ...
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Isolation and identification of l-glutaminase producing fungi from agricultural soil
... contains L-glutamine as sole carbon and nitrogen source and phenol red acts as a pH ...extracellular L-glutaminase production by the fungal ...the L-glutaminase causes the breakdown of ...
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Isolation And Identification Of L-Glutaminase An Antileukemic Enzyme Producing Mico-Organism From Godavari River Bank Soils In Andhra Pradesh
... the L-glutamine to L-glutamic acid and ammonia. L-glutamine has a significant role in nitrogen metabolism at cellular level 1-4 .... L- glutamine and L-glutamate are one of the ...
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Biosynthesis of L Glutaminase by Streptomyces Variabilis ASU319 Isolated from Rhizosphere of Triticum Vulgaris
... of L-glutaminase enzyme. The most potent L-glutaminase producer isolate was Streptomyces ...affecting L-glutaminase production by the Streptomyces variabilis ASU319(KC145278) ...
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Journal of Applied Pharmaceutical Science
... cellular L-glutaminase production by the ...as L- glutaminase causes the breakdown of amide bond in L-glutamine and liberates ...of L-glutaminase producer among the ...
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MULTIPLE ENZYME PRODUCER GORDONIA TERRAE FROM LONAR LAKE
... study L-asparaginase producing isolates were screened from water samples of Lonar Lake, Buldhana, ...extracellular L-asparaginase production was found to be Gordonia terrae strain 5-Sj-4-3-2-M by 16sRNA ...
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A REVIEW ON BIOCHEMICAL AND THERAPEUTIC ASPECTS OF GLUTAMINASE
... as L- ...of L-Glutaminase production, aiming to comprehend the physicochemical characteristics, application of L-Glutaminase and its ...of L- glutaminase producing ...
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LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer
... L-type amino acid transporter 2 (LAT2), encoded by the SLC7A8 gene, belongs to the SLC7 subfamily of the LAT family [9]. LAT2 is a Na + -independent neutral amino acid transporter and is responsible for transport- ...
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Targeted inhibition of tumor specific glutaminase diminishes cell autonomous tumorigenesis
... Although BPTES is an effective tool compound for study- ing GLS, efforts have now yielded a new, more potent allosteric inhibitor of GLS, CB-839, that is being tested clinically (16). The challenge now lies in the ...
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<p>Effect of glutaminase inhibition on cancer-induced bone pain</p>
... Figure 7 Glutathione synthesis for ROS detoxi fi cation drives metabolic adaptations to maintain glutamate production and cystine acquisition in the absence of GLS activity. Glutathione synthesis for ROS detoxification ...
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Experimental Metabolic Acidosis: The Enzymatic Basis of Ammonia Production by the Dog Kidney
... If these derivations are valid, the glutaminase activity present in the normal dog kidney has the capacity to split from glutamine the increased amount of NH3 produced in metabolic acido[r] ...
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Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer
... the glutaminase inhibitor CB-839, which currently is in early clinical trials for TNBC patients, significantly inhibits tumor growth in one of the breast cancer PDX models, the luminal b/ER + ...to ...
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Original Article Expression of glutaminase is upregulated in colorectal cancer and of clinical significance
... For glutaminase inhibition, DON was administered to cells in a concentra- tion gradient of 0, 10, 20, 40 and 80 μmol for 24 and 48 hours. After treatment, cell growth was tested by MTT assay, and the apoptotic ...
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PubMedCentral-PMC5033692.pdf
... Hepatic encephalopathy (HE) or brain dysfunction due to cirrhosis represents a major healthcare burden in subjects with cirrhosis(1). Cirrhosis is associated with dysbiosis or an altered gut microbiota that potentiates a ...
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TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase
... EVs are associated with the message delivery of the ner- vous system and may involve in the pathogenesis of many neuroinflammatory disorders, both infectious and neuro- degenerative [36]. However, the mechanism ...
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