l-NMMA
Central nervous system nitric oxide synthase activity regulates insulin secretion and insulin action
... L -NMMA–induced insulin resistance is coincident with the on- set of hypertension (14), and thus, one could speculate that in- sulin resistance is etiologically related to hypertension in this model. ...
11
Nicolaus, Mathias (2003): Regulation der gastroduodenalen Motilität und Perzeption durch endogenes Stickstoffmonoxid (NO) beim Menschen: Wirkungen und cholinerge Interaktion. Dissertation, LMU München: Medizinische Fakultät
... Bisherige Erkenntnisse zur Rolle von NO beziehen sich allerdings auf tierexperimentelle und in-vitro-Studien einerseits, andererseits auf Humanstudien, bei denen die Effekte von exogenem NO oder NO-Donoren auf die ...
121
A nitric oxide like factor mediates nonadrenergic noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle
... by L-NMMA, oxyhemoglobin, methylene blue, and ...of L-NMMA were reversed by L-arginine and the effects of hypoxia were readily reversed by normoxic ...
8
Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase
... Abbreviations used in this paper: BAEC, bovine aortic endothelial cells; L-NMMA, L-N-monomethyl arginine; NOS, nitric oxide synthase; SSC, standard saline citrate; TNFa, tumor necrosis f[r] ...
6
Tumor necrosis factor alpha dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide independent aggrecanase activity in vitro
... inhibitor L- NMMA on meniscal tissue. L-NMMA had no significant influ- ence on the basal GAG release and did not reduce the TNFα- induced effect (Figure ...
9
Nitric oxide release accounts for insulin's vascular effects in humans
... clamp. L-NMMA (but not norepinephrine, an NO-independent vasoconstrictor) caused larger reductions in forearm blood flow during hyperinsulinemia than at ...Moreover, L-NMMA prevented insulin- ...
6
Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxidedelivery
... Intra-arterial L - NMMA at 8 µ mol/min then replaced 5% dextrose in water at the same infusion rate of ...of L -NMMA in humans are reproducible at this dosage when infusions are separat- ed in ...
10
Insulin mediated skeletal muscle vasodilation is nitric oxide dependent A novel action of insulin to increase nitric oxide release
... hyperinsulinemic clamp (HIC) designed to approximately double LBF. In response to the intrafemoral artery infusion of L-NMMA, LBF decreased from 0.296 +/- 0.032 to 0.235 +/- 0.022 liters/min during NS and ...
9
Nitric oxide balances osteoblast and adipocyte lineage differentiation via the JNK/MAPK signaling pathway in periodontal ligament stem cells
... by L -N G -monomethyl arginine ( L -NMMA) during osteogenic or adipogenic induction, while sodium nitroprusside (SNP) significantly increased the expression of ...
12
Tetrahydrobiopterin restores endothelial function in hypercholesterolemia
... many), l -arginine hydrochloride (Bufa, Uitgeest, The Netherlands), L-NMMA (Sigma Chemical ...(6R)-5,6,7,8-tetrahydro- l -biop- terindihydrochloride (BH4; Alexis ...
7
Platelet derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta and cAMP induced nitric oxide synthase expression in rat renal mesangial cells
... nonmetabolizable L -arginine analogue L-NMMA causes inhibition of NO formation and reduction in renal blood flow (45) and glomerular filtration rate in rats ...
11
Role of endothelium derived nitric oxide in the bleeding tendency of uremia
... rats. L-NMMA injection also increased ex vivo platelet adhesion but did not affect ex vivo platelet aggregation induced by adenosine diphosphate, arachidonic acid, and calcium ionophore ...of ...
5
Angiotensin II induced inotropism requires an endocardial endothelium nitric oxide mechanism in the in vitro heart of Anguilla anguilla
... Losartan, L -arginine, haemoglobin, L -NIO, L - NMMA, PTx, Triton X-100, ISO, phenylephrine, propanolol, phentolamine, sotalol and atropine sulphate salt were purchased from Sigma Chemical ...
10
Endothelium dependency of contractile activity differs in infant and adult vertebral arteries
... arteries and were abolished by indomethacin (but not L-NMMA) in infants and L-NMMA (but not indomethacin) in adults. Thus, endothelium-dependent responses in infant arteries are attenuated ...
6
Nitric oxide modulates cardiac performance in the heart of Anguilla anguilla
... to L -arginine (10 −7 mol l −1 ), the natural substrate for NOS. L -Arginine induced a significant decrease in V S and W S ...of L -arginine were due to NO because they were abolished by ...
9
Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation
... time. L-NMMA but not aminoguanidine, dexamethasone, or cycloheximide attenuated NO2- and PGE2 release indicative of the presence of constitutive but not inducible NOS or ...
9
CYP2J3 Gene Delivery Reduces Insulin Resistance via Upregulation of eNOS in Fructose-treated Rats
... inhibitor L-NMMA significantly and partially abol- ished the beneficial effects of CYP2J3 gene delivery on hypertension induced by fructose intake, and its possible mechanism is associated with increased ...
10
Vasodilatory effect of arginine vasopressin is mediated by nitric oxide in human forearm vessels
... of L-arginine (a precursor of NO) and NG-monomethyl-L-arginine (L-NMMA, a blocker of NO synthase) on AVP-induced ...infused L-arginine at 10 mg/min did not alter arterial pressure, ...
9
L Alanyl L threonine
... 1999); l-Arg±l-Ser acetate monohydrate (Verdauger et al., 1991); l-Lys±l-Tyr±l-Ser acetate (Verdaguer et ...1990); l-Arg±l-Ser Gly±l-Glu (1:1) (Suresh & ...
7
(L.) , A. sativa (L.) , A. sterilis
... of 650 × 12 nm were observed in crude sap from leaves by electron microscope. The cylindrical in- clusions (pinwheels), characteristic for the family Potyviridae, were observed by electron microscope in ultra-thin ...
5