L-triiodothyronine
Differences in primary cellular factors influencing the metabolism and distribution of 3,5,3′ L triiodothyronine and L thyroxine
... Administration of phenobarbital, which acts exclusively on cellular sites, results in an augmentation of the liver/plasma concentration ratio of L-thyroxine (T4) in rats but no change in the liver/plasma ...
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Determination of Iodothyronine Absorption and Conversion of L Thyroxine (T4) to L Triiodothyronine (T3) using Turnover Rate Techniques
... of L-thyroxine (T 4 ) and L-triiodothyronine (T 3 ) and the fractional rate of conversion of T 4 to T 3 were determined from the turnover rates of T 4 and T 3 in seven patients without endogenous ...
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A STUDY OF THE RATE OF PROTEIN SYNTHESIS BEFORE AND DURING THE ADMINISTRATION OF L TRIIODOTHYRONINE TO PATIENTS WITH MYXEDEMA AND HEALTHY VOLUNTEERS USING N 15 GLYCINE
... A STUDY OF THE RATE OF PROTEIN SYNTHESIS BEFORE AND DURING THE ADMINISTRATION OF L-TRIIODOTHYRONINE TO PATIENTS WITH MYXEDEMA AND HEALTHY VOLUNTEERS USING N-15 GLYCINE K... A STUDY OF TH[r] ...
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A New Radioimmunoassay for Plasma l Triiodothyronine: Measurements in Thyroid Disease and in Patients Maintained on Hormonal Replacement
... of l-triiodothyronine (T 3 ) in human plasma is described in which the iodothyronines are separated from the plasma proteins before incubation with a specific antiserum to T 3 ...of l-thyroxine (T 4 ...
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THE EFFECT OF PLASMA ON THE IN VITRO UPTAKE OR BINDING BY HUMAN RED CELLS OF RADIOACTIVE I 131 LABELED L THYROXINE AND L TRIIODOTHYRONINE
... The possibility that the uptake or binding 8 by the red cell of L-thyroxine or L-triiodothyronine Effect of incubating unwashed red cells with is due to contamination with inorganic iodi[r] ...
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Concentration of l Thyroxine and l Triiodothyronine Specifically Bound to Nuclear Receptors in Rat Liver and Kidney: QUANTITATIVE EVIDENCE FAVORING A MAJOR ROLE OF T3 IN THYROID HORMONE ACTION
... of l-triiodothyronine (T 3 ) and l-thyroxine (T 4 ) to thyroidal effects, we have measured the concentration of iodothyronine bound to specific hepatic nuclear receptor sites by three different ...
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Propylthiouracil inhibits the conversion of l thyroxine to l triiodothyronine: An explanation of the antithyroxine effect of propylthiouracil and evidence supporting the concept that triiodothyronine is the active thyroid hormone
... conversion of L-thyroxine to L-triiodothyronine (T 3 ). These effects could not be ascribed to induced hypothyroidism since the group maintained on 5 µg T 4 /day had normal levels of liver ...
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L triiodothyronine stimulates growth by means of an autocrine factor in a cultured growth hormone producing cell line
... L-Triiodothyronine (T3) stimulates DNA synthesis and replication of cultured GC cells, a T3- responsive growth hormone (GH)-secreting cell line. To determine whether T3 stimulates secretion of an autocrine ...
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Response of hepatic mitochondrial alpha glycerophosphate dehydrogenase and malic enzyme to constant infusions of L triiodothyronine in rats bearing the Walker 256 carcinoma Evidence for divergent postreceptor regulation of the thyroid hormone response
... to L-triiodothyronine (T3) in an experimental nonthyroidal disease, we determined the activity of hepatic mitochondrial alpha- glycerophosphate dehydrogenase (alpha-GPD) and cytosol malic enzyme (ME) as a ...
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Thyroid Hormonelike Actions of 3,3′,5′ l Triiodothyronine and 3,3′ Diiodothyronine
... l-Thyroxine is converted to 3,5,3¢-l-triiodothyronine (T 3 ) as well as to 3,3¢,5¢-l-triiodothyronine (reverse T 3 ). One product of further deiodination is 3,3¢-diiodothyronine (3,3¢T ...
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Lack of significant binding of L triiodothyronine by thyroxine binding globulin in vivo as demonstrated by acute disappearance of 131 I labeled triiodothyronine
... The T3 acute the T4 binding capacity of TBG in all patients half-time, on the other hand, had a mean of 76.1 studied, with a mean of 50.4 ,ug per 100 ml of minutes, which was not signifi[r] ...
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l Triiodothyronine and l Reverse Triiodothyronine Generation in the Human Polymorphonuclear Leukocyte
... triiodothyronine (T 3 ) and l-reverse-triiodothyronine (rT 3 ) production. To define some of the cellular factors involved, we examined T 3 and rT 3 generation from added nonradioactive T 4 in human ...
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Stimulation of hepatic mitochondrial alpha glycerophosphate dehydrogenase and malic enzyme by L triiodothyronine Characteristics of the response with specific nuclear thyroid hormone binding sites fully saturated
... triiodothyronine (T3), the level of plasma and hepatic nuclear T3 attained, and the tissue response as reflected in increased activity of hepatic mitochondrial alpha-glycerophosphate dehydrogenase (alpha-GPD) and ...
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CALORIGENIC EFFECTS OF SINGLE INTRAVENOUS DOSES OF L TRIIODOTHYRONINE AND L THYROXINE IN MYXEDEMATOUS PERSONS
... When compared on the basis of the maximal metabolic rate resulting from a given injection, triiodothyronine appeared to be three or four times as potent as thyroxine.. On the basis of to[r] ...
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DISAPPEARANCE FROM SERUM OF I131 LABELED L THYROXINE AND L TRIIODOTHYRONINE IN EUTHYROID SUBJECTS
... This slow exponential component of the disappearance curve was interpreted as the rate of degradation of the administered radiothyroxine or replacement of tagged by untagged thyroxine, h[r] ...
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Limited Binding Capacity Sites for l Triiodothyronine in Rat Liver Nuclei: NUCLEAR CYTOPLASMIC INTERRELATION, BINDING CONSTANTS, AND CROSS REACTIVITY WITH l THYROXINE
... Further studies have been performed to define the kinetic characteristics of nuclear triiodothyronine (T 3 ) binding sites in rat liver (J. Clin. Endocrinol. Metab. 1972. 35: 330). Sequential determination of ...
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Augmentation of the Peripheral Metabolism of l Triiodothyronine and l Thyroxine after Acclimation to Cold: MULTIFOCAL STIMULATION OF THE BINDING OF IODOTHYRONINES BY TISSUES
... stimulation of the binding of these hormones by diverse tissues, suggesting the participation of extrahepatic degradative foci in the increased hormonal deiodination observed in vivo. Increased hepatocellular binding and ...
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Thyroid Adrenocortical Interrelations: Failure to Demonstrate Antagonism Between Triiodo thyronine and Hydrocortisone in Man
... If the metabolic effects between large doses of hydroconcept under consideration were correct, it would cortisone and l-triiodothyronine in two normal huprove that the effects of these t[r] ...
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A STUDY OF THE RELATIVE BINDING CAPACITY OF PLASMA PROTEINS, INTACT HUMAN RED CELLS, AND HUMAN RED CELL STROMA FOR RADIOACTIVE I 131 LABELED L THYROXINE
... THE UPTAKE OF RADIOACTIVE I-131 L-THYROXINE AND L-TRIIODOTHYRONINE BY RED CELL STROMA, THE EFFECT OF FRESH HUMAN PLASMA ON THE UPTAKE OF L-THYROXINE, AND THE AMOUNT OF RADIOACTIVITY REMA[r] ...
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PLASMA NONESTERIFIED FATTY ACIDS IN HYPERTHYROID STATES
... MEAN CHANGES OF PLASMA, CHOLESTEROL NEFA CONCENTRATIONS AND OF BASAL METABOLIC RATES OF EUTHYROID SUBJECTS TREATED WITH L-TRIIODOTHYRONINE TRITH FOR ONE MONTH... NONESTERIFIED FATTY ACID[r] ...
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