?-lactams
Synthetic Lethality Reveals Mechanisms of Mycobacterium tuberculosis Resistance to β Lactams
... ABSTRACT Most  -lactam antibiotics are ineffective against Mycobacterium tuberculosis due to the microbe’s innate resistance. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has ...
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“Do Prolonged Infusions of Beta Lactams Improve Clinical Cure? A Meta Analysis” by Fahmi Hassan, Noorizan Abdul Aziz, Yahaya Hassan, Hazlinda Abu Hassan, Nurnadia Shazreen, Abdul Wahab, Malaysia.
... beta lactams have always been given as intermittent doses as per instructions of individual product leaflet of the ...Beta lactams have known to be time-dependent ...
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Facile Synthesis of Novel C-3 Monosubstituted 3-phenylthio- -lactams
... Synthesis of cis -and trans -C-3 monosubstituted phenylthio- β-lactams 6(a-j) and 7(a-j): Compounds 6(a-j) and 7(a-j) were prepared by using the same method as for C-3 substituted phenylthio-β-lactams 11,12 ...
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Detection of 16S rRNA Methylases and Co-Resistance with β-lactams among Klebsiella pneumoniae Isolates from Iraqi Patients
... Out of 150 clinical samples, 50 isolates of Klebsiella pneumoniae were identified according to morphological and biochemical properties. These isolates were collected from different clinical samples, including 15 (30%) ...
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Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of β lactams
... An improved PD profile of b-lactams may be obtained by promoting a longer exposure with more frequent dosing, extended infusions or continuous infusions [86,87]. Several of the studies that we reviewed reported PD ...
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Ring-Expansion Approach to Medium-Sized Lactams and Analysis of Their Medicinal Lead-Like Properties
... medium-sized lactams has been generated using a simple, scalable and versatile ring expansion ...these lactams and their derivatives have highly promising physicochemical and 3D spatial properties and thus ...
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Microwave assisted benzylic c h activation using ruthenium catalysts Synthesis of lactams
... been successfully used for Kharasch–type additions (Severin et al. 2006; Delaude et al. 2004). When 1a was treated with 10% of Ru3 at 100 °C in toluene for 15 min using microwaves, we were delighted to see that lactam 2a ...
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A construction of 4,4-spirocyclic γ-lactams by tandem radical cyclization with carbon monoxide
... We have examined a TTMSS-mediated 5-exo radical cycliza- tion/carbonylation/spirocyclization sequence to synthesize 4,4- spirocyclic rings. By using this protocol, indoline, benzofuran and oxindole γ-lactams can ...
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Synthesis of Some New Spiro β Lactams and Thiazolidinones Compounds Containing Sulfur Incorporating Quinon Compounds
... β-Lactams, being a structural unit found in the most widely used antibiotics [1], have occupied a basic posi- tion in medicinal chemistry for almost a century now. With the microbes basic position in medicinal ...
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Reactivity of β lactams and phosphonamidates and reactions with β lactamase
... Pure &Apple Chem , Vol 67, No 5, pp 711 717,1995 Printed in Great Britain CD 1995 IUPAC Reactivity of p lactams and phosphonamidates and reactions with P lactamase M I Page, A P Laws, M J Slam and J R[.] ...
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Some hydrolytic reactions of beta lactams
... solution (and dioxan to give a final dioxan concentration of 0,8^) and of sodium hydroxide being simultaneously introduced to the reaction chamber and the increase in absorption of 400 nm displayed on a cathode ray tube, ...
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Analysis of Trends in Resistance to Fluoroquinolones and Extended Spectrum Beta Lactams among Salmonella Typhi Isolates Obtained from Patients at Four Outpatient Clinics in Nairobi County, Kenya
... Typhoid fever caused by the bacterium Salmonella enterica serovar Typhi ( S . Typhi) causes an estimated 25 million illnesses and approximately 200,000 deaths annually mostly in developing countries. Although the ...
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Increased β Lactams dosing regimens improve clinical outcome in critically ill patients with augmented renal clearance treated for a first episode of hospital or ventilator acquired pneumonia: a before and after study
... Increased β-Lactams dosing regimens improve clinical outcome in critically ill patients with augmented renal clearance treated for a first episode of hospital or ventilator-acquired pneu[r] ...
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Mild to moderate hypersensitivity reactions to beta-lactams in children: a single-centre retrospective review
... history of benign nonimmediate allergy to beta-lactams in children: a prospective study in retreated patients after a positive and a negative provocation test. Faitelson Y, Boaz M, Dal[r] ...
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Haemophilus influenzae ATCC 49766, an alternative quality control strain for monitoring broth microdilution susceptibility tests with selected beta lactams
... Haemophilus influenzae ATCC 49766, an Alternative Quality Control Strain for Monitoring Broth Microdilution Susceptibility Tests with Selected ,B-Lactams.. Received 10 February 1992/Acce[r] ...
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Pharmacodynamic optimization of β lactams in the patient care setting
... Although pharmacokinetic/pharmacodynamic principles have not changed over the past 60 years, antibiotic administration strategies are in flux, as the prevalence of resistance increases and as effective antibiotics become ...
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A calorimetric study of β sultams and β lactams
... A calorimetric study will follow. Where hydrolysis experiments were conducted under varying conditions in the solid state, varying RH, water/solvent mixtures and buffer controlled conditions. The calorimetric data will ...
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β LACTAMS: A MINI REVIEW OF THEIR BIOLOGICAL ACTIVITY
... Natural and synthetic β-lactam derivatives occupy a central place among medicinally important compounds due to their diverse and interesting antibiotic activities and are still the most [r] ...
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SYNTHESIS OF NEW DRIMANE AND HOMODRIMANE LACTAMS BY BECKMANN REARRANGEMENT OF SOME KETOXIMES
... have obtained a mixture of isomeric furanolactams, derivatives of octahydro-1H- benzo[d]azepine 12 and octahydro-1H-benzo[c]azepines 13 and 14 by the Beckmann rearrangement of the [r] ...
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Allergy to β-Lactam Antibiotics in Children
... Sixth, negative skin test results with positive OC test results also may result from allergy or intoler- ance to substances not used in skin tests such as clavulanic acid and excipients. In 3 children, allergy to ...
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