Lamin A
The clinicopathological significance of lamin A/C, lamin B1 and lamin B receptor mRNA expression in human breast cancer
... A, lamin B and lamin B receptor (LBR), are nuclear proteins that are found on the inner side of the nuclear ...especially lamin B, as part of the nuclear lamina, anchor specific areas of the genome ...
17
Nuclear accumulation of UBC9 contributes to SUMOylation of lamin A/C and nucleophagy in response to DNA damage
... that lamin A/C could be a target of SUMOylation medi- ated by UBC9 ...that lamin A/C was SUMOylated by ...or lamin A/C, suggesting that UBC9 interacts with lamin ...of lamin A/C and ...
14
Prelamin A and lamin A appear to be dispensable in the nuclear lamina
... products lamin A and lamin C is unclear, although several reports have suggested that lamin A may have particularly important functions, for example in the targeting of emerin and lamin C to ...
11
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
... lack lamin A and lamin C, most human diseases arise from heterozygous lamin ...mutant lamin often appears as stable as WT lamin and is expressed at similar levels ...of lamin A/C ...
10
Circulation autoantibody against Lamin A/C in patients with Sjögren’s syndrome
... expression. Lamin A/C has been confirmed as an autoantigen in RA, SLE and ...confirm Lamin A/C is an autoantigen in Han Chinese patients with confirmed Sjögren’s syndrome ...of Lamin A/C epitope and ...
10
Overexpression and cytoplasmic localization of caspase-6 is associated with lamin A degradation in set of ovarian cancers
... caspase-6 prior to apoptosis is no longer applicable due to the absence of lamin A. Indeed, in cancer cells, there is an alteration of cell proliferation and apoptotic markers [12]. From our investigation active ...
12
Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C–deficient mice
... LV, LA, and skeletal muscle are more extensive than reported previously in hepatocytes (25), suggesting that structural defects in the lamina may render the nucle- us more susceptible to deformation within a contrac- ...
14
Effects of Lamin A/C, Lamin B1, and Viral US3 Kinase Activity on Viral Infectivity, Virion Egress, and the Targeting of Herpes Simplex Virus UL34-Encoded Protein to the Inner Nuclear Membrane
... of lamin A/C have been described previously (23). An immor- talized lamin A/C knockout mouse embryonic fibroblast (MEF) cell line lacking the gene encoding lamin A/C (LmnA ⫺/⫺ ) was a gift from Colin ...
11
Interruption of progerin–lamin A/C binding ameliorates Hutchinson Gilford progeria syndrome phenotype
... recombinant lamin A or progerin, we could estimate that progerin–lamin A binding affinity is more than 2-fold stronger than that of lamin A–lamin A binding (Figure ...does lamin A or C ...
16
Molecular Genetic Analysis of the Nested Drosophila melanogaster Lamin C Gene
... to lamin aggregations observed in mammalian cell culture upon overexpressing human lamin rod domain mutants (O stlund et ...2003). Lamin aggregration phenotypes, including O-ring structures, are ...
12
From Engineering of Tumor Shrinking Dds to Engineering the Nucleus for Tumor Growth
... B-type Lamin isoforms play separate roles in nuclear shape and ...When Lamin-B is the dominant isoform as in the U251 cells, the nucleus readily recovers after deformation through a small pore, behaving ...
140
Lamin B1 mediates cell autonomous neuropathology in a leukodystrophy mouse model
... brane (3). Mutations of the X-linked PLP1 gene encoding PLP, the most abundant protein of the CNS myelin sheath, cause Pelizaeus- Merzbacher disease (PMD), another rare leukodystrophy (4). Muta- tions in PLP1 ultimately ...
12
Emerin Is Hyperphosphorylated and Redistributed in Herpes Simplex Virus Type 1-Infected Cells in a Manner Dependent on both UL34 and US3
... Emerin is hyperphosphorylated in HSV-1-infected cells, as shown by decreased mobility of emerin and greater heteroge- neity of mobility in SDS-PAGE gels and the complete revers- ibility of the changes in mobility by ...
12
Mechanosensing By The Nuclear Lamina: From Embryonic Development To Aging
... nucleus, lamin-A, which is abundant in stiff and mechanically stressed tissues such as striated muscle, but is comparatively low in soft tissues such as the ...brain. Lamin-A’s increase with tissue ...
168
Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer
... and lamin A/C as the molecular basis of nuclear defor- mation in cancer cells may provide some ...or lamin A/C (current study) lead to mitotic failure and the formation of polypoid and subsequent aneuploid ...
12
Regulation of Myelination in the Central Nervous System by Nuclear Lamin B1 and Non coding RNAs
... with lamin deficiency all displayed abnor- mal nuclear structures ...A-type lamin confer phenotypes by gain-of-function toxicity for some models and loss-of- function for others ...[55]. Lamin B1 has ...
8
A novel LMNA mutation (R189W) in familial dilated cardiomyopathy: evidence for a 'hot spot' region at exon 3: a case report
... for lamin B interac- tion and lamin A/C ...of lamin A and C, may lead to a weaker nuclear lamina with subsequent mechanical stress damage by muscle contraction and abnormal mechano-transduction ...
5
Lamin mutation location predicts cardiac phenotype severity: combined analysis of the published literature
... Figure 2 Mutational landscape in lamin heart disease. A Circos of mutation subtype in cDNA order along the LMNA gene. Each mutation is described in online supplementary table 1. Exon boundaries are demarcated by ...
9
Reorganization of Nuclear Pore Complexes and the Lamina in Late-Stage Parvovirus Infection
... general, lamin intensities were higher at the apical side than at the basal side ...of lamin B1 was slightly increased whereas that of lamin A/C was similar to that in the mock-infected cells ...of ...
5
Wendl, Josef Reinhard Werner Erik (2012): Follikulogenese und Intermediärfilamente: Eine immunhistochemische Studie am Ovar des Rindes mit Verweisen auf Laser-Mikrodissektion und anschließender quantitativer Reverse-Transkriptase PCR. Dissertation, LMU München: Tierärztliche Fakultät
... desmin, lamin A and lamin B1 in the bovine ovary, considering the different developmental follicle stages and various ovarian tissues including the surface epithelium, stroma cells, endothelium, smooth ...
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