large animal
Completion of the swine genome will simplify the production of swine as a large animal biomedical model
... When compared to other large animal models, swine reach sexual maturity early (6–8 months), have a short gestation length (~4 months) and give birth to multiple offspring. Additionally swine are not ...
11
Methylguanine methyltransferase–mediated in vivo selection and chemoprotection of allogeneic stem cells in a large animal model
... any large-animal or human ...a large-animal model and suggest that chemoprotection can also be used to enhance allogeneic stem cell ...
9
Large animal models in experimental knee sports surgery: focus on clinical translation
... joint. Large animal models for the treatment of ligamentous ACL lesions may help to overcome the therapeutic dilemma of how to treat such tears in the paediatric ...preclinical large animal ...
12
A large animal neuropathic pain model in sheep: a strategy for improving the predictability of preclinical models for therapeutic development
... that only the common peroneal nerve is injured. A clear advantage of using a large animal model such as sheep is the similarity in body size to humans. This allows us to use clinical sensory testing ...
10
A Large Animal Survival Model to Evaluate Bariatric Surgery Mechanisms
... The objective of this study was to determine the feasibility and appropriateness of bariatric surgical tech- niques in the Ossabaw survival model. The advantages of a large-animal model are its similarities ...
9
CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases
... generate large animal models of diseases, such as non- human primate models of neurodegenerative disease ...and large animals to generate genetic mutations that can faithfully mimic pathology in ...
8
An improved mounting device for attaching intracranial probes in large animal models
... using animal models, as mounting devices suitable for the probes are either not available, or designed for human use and not suitable in animal ...in large animal models is ...of large ...
5
Effects of Functional Electrical Stimulation on Denervated Laryngeal Muscle in a Large Animal Model
... Cheetham, J., Perkins, J. D., Jarvis, J. C., Cercone, M., Maw, M., Hermanson, J. W., Mitchell, L. M., Piercy, R. J. and Ducharme, N. G. (2015), Effects of Functional Electrical Stimulation on Denervated Laryngeal Muscle ...
26
Mixed chimerism and tolerance without whole body irradiation in a large animal model
... The ability to achieve hematopoietic stem cell engraftment without WBI has many advantages for clinical applications. Previous studies in miniature swine, using WBI as part of the preparative regimen, have produced ...
12
Large animal models for stem cell therapy
... of animal models for gaining this information has increased ...novel animal models to expand the range of current studies, most of which have been conducted in ...of animal-based preclinical studies ...
9
Effects of N-acetyl-L-cysteine on Postoperative Intrabdominal Adhesion in a Large Animal Model
... in large animal model to our knowledge has never been ...in large animal when administered ...appropriate animal model for quickly and effectively extrapolation of results from the ...
10
Large Animal Models of Intestinal Disease.
... Liara M. Gonzalez was born on January 25, 1981, in White Plains, New York. She is the youngest of five children with an oldest sister and three brothers. Liara attended Edwin O. Smith High School in Storrs, CT and ...
298
Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large animal model
... These studies in miniature swine provide the first evi- dence for donor-specific tolerance induced by the mixed chimerism approach in a large-animal model. Donor skin graft survival was significantly ...
10
Methods for monitoring tidal flushing in large animal burrows in tropical mangrove swamps
... numerous animal burrows perforating the sediments of salt marshes and mangroves, and its potential enhancement of nutrient and oxygen exchange, has been well ...
6
Structural and functional correlations in a large animal model of bleomycin-induced pulmonary fibrosis
... small animal models of pulmonary fibrosis incorporate long term lung func- tional measurements into their ...small animal models, which typically induce fibrosis to the whole ...
15
A polypropylene mesh modified with poly-ε-caprolactone nanofibers in hernia repair: large animal experiment
... Significant improve- ment of biocompatibility of polypropylene mesh for incisional hernia repair by using poly- ε -caprolactone nanofibers functionalized with thrombocyte-rich so[r] ...
15
Efficient Inference of Haplotypes From Genotypes on a Large Animal Pedigree
... problem (L i and J iang 2004) contains five functions for inferring haplotypes from genotypes for members of a general pedigree. Two functions ½locus-based dynamic programming (DP) and member-based DP are expo- nential ...
9
Resuscitation speed affects brain injury in a large animal model of traumatic brain injury and shock
... A total 23 Female Yorkshire swine (40–50 kg; Tufts Veterinary School, Grafton, MA) were used and allowed three days for acclimatization prior to surgery. Of these, 20 animals were primarily used for and included in other ...
10
Left ventricular twist is load-dependent as shown in a large animal model with controlled cardiac load
... show large changes related to the load alteration with IVCBO in the control resting stage, though there were tendencies for tau to in-crease and PHT to decrease during load reduction in the inotropic treat- ment ...
9
Large Animal Models to Study Intestinal Stem Cell Mediated Repair.
... with large intestinal disease, a signifi- cant difference in TNF- a expression was found in diseased mucosa, suggesting a possible role for this cytokine in the pathogenesis of equine IBD ...
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